Crimean State Humanitarian University

Yalta, Ukraine

Crimean State Humanitarian University

Yalta, Ukraine

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Hnatush A.R.,Ivan Franko National University of Lviv | Drel V.R.,Ivan Franko National University of Lviv | Hanay N.O.,Ivan Franko National University of Lviv | Yalaneckyy A.Y.,Ivan Franko National University of Lviv | And 2 more authors.
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2013

Peripheral nerve damage is a significant complication of diabetes mellitus. The ingestion of polyphenols available naturally in a variety of plant products may provide impressive protection against such damage. The natural polyphenol complex of grape wine has a significant anti-diabetic effect. It can protect against dehydration at the level of the whole organism and deter free radical-induced damage to the sciatic nerve, the spinal cord, kidney and retina. The levels of nitrosylated and PARylated proteins can be restored to near control levels by the extract. The biochemical mechanisms of action of the natural polyphenol complex of grape wine require further research, but may be considered as a valuable therapeutic approach for the treatment of diabetic complications. © 2013 Springer Science+Business Media Dordrecht.


Iezhov V.V.,Si Georgievsky Crimean State Medical University | Mizin V.I.,Crimean State Humanitarian University | Yalaneckyy A.Y.,National Institute for Vine and Wine Magarach
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2013

As was established in previous investigations, consumption of grape's polyphenols, containing in food concentrate Enoant, increase effectiveness of recuperative sanitaria treatment in patients with arterial hypertension and chronic bronchitis. In current article, we present the results of investigation of the wine stress-limiting effects caused by alcohol and polyphenol components. The investigation was performed in 60 patients with arterial hypertension, 60 patients with chronic bronchitis and 60 patients with chronic fatigue syndrome. White table dry wine was used under complex recuperative sanitaria treatment in patients with arterial hypertension and chronic bronchitis and the Ukrainian sparkling wine was used under complex recuperative spa treatment in patients with chronic fatigue syndrome. The dry wine was prepared from white grape "Rkacitely" along with Kakhetian technology. The analysis of data reveals that the most positive wine effect is a successful coping with stress. We had seen significantly increased changes in psychological and morphological reactions, including positive dynamics of the following: patient's self indicated feeling, amount of total complaints and stress reactions, adaptation, diastolic blood pressure, minute blood volume, right carotid artery rheographic index and Gentch test. Also, about quarter of patients had noted the diminishing of wish to drink strong alcohol beverages. The results are in good accordance with the previously known action of grape's wines to prevent heart and vessels diseases. © 2013 Springer Science+Business Media Dordrecht.


Solyanik G.,R.E. Kavetsky Institute of Experimental Pathology | Mizin V.I.,Crimean State Humanitarian University | Pyaskovskaya O.,R.E. Kavetsky Institute of Experimental Pathology | Banakchevich N.,Ministry of Public Health of Ukraine | Ogay Y.A.,Private Enterprise Ressfood
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2013

Anticancer drugs do not possess sufficient specificity of action. Each cytostatic agent shows a wide spectrum of side effects that limit the efficacy of therapy and make the quality of life for a cancer patient worse. It forces scientists to search for new pharmacological agents for the correction/ prevention of side effects. The polyphenolic compounds are naturally occurring phytochemicals that could be considered as potentially effective protectors of cancer chemotherapy toxicity. The main goal of the study was to study the ability of the grape polyphenol concentrated product Enoant to reduce hematotoxicity of cancer cytotoxic chemotherapy. In a preclinical study, the influence of Enoant on both hematotoxicity and the efficacy of cisplatin administered into Lewis lung carcinoma bearing mice was investigated. Enoant provided a significant protection against cisplatin-induced hematotoxicity by increasing red blood cell production and normalizing leukocyte levels in tumor-Â-bearing mice. Enoant did not stimulate tumor growth and metastasis and did not reduce the efficacy of cisplatin-based therapy. Twenty cancer patients with anemia (averaged hemoglobin level was 85.8±0.8 g/L) were included in the clinical study. The correction of anemia during the first stage of investigation was conducted using either iron-containing drugs or erythropoietin. This gave the possibility to begin the course of cancer chemotherapy in 6.7±1.0 days when the hemoglobin level reached 94.6±1.8 g/L. Before the next course of anticancer treatment, the patients received Enoant (total dose of polyphenols was 5 g), that resulted in an 11 % increase of hemoglobin levels (p<0.05) up to 103.5±2.8 g/L. Thus, Enoant is an effective and safe agent for the treatment of cancer associated anemia. Enoant is well accepted by patients. Its safety, convenient oral form and palatability make it possible to carry out an effective correction of anemia at home. © 2013 Springer Science+Business Media Dordrecht.


Brunner E.Y.,Crimean State Humanitarian University | Mizin V.I.,Crimean State Humanitarian University
NATO Science for Peace and Security Series A: Chemistry and Biology | Year: 2013

The process of learning can be regarded as a model of psychological stress, since any active operator has to cope with the tasks of attentive and quick perception and memorizing of information, to work out an adequate behavior model as well as to implement it in practice. Forty-three students (23 - main group, 20 - control group) took part in the estimation of psychological state, personality characteristics, auditory arbitrary memory, the dynamics of attention processes, attention qualities, speed of sensor-motor reaction and thinking operations. The students of the main group ingested the alcohol-free dietary grape polyphenol concentrate Enoant for 20 days at a daily dose of 35 ml. Statistically significant changes, such as (i) improvement of the activity and mood; (ii) improvement of attention, (iii) increase in thinking productivity and concentration of attention; (iv) quantity of the processed visual information and the rapidity of processing; (v) improvement of the examinees short-term and working memory; (vi) increase of intellectual work capacity; (vii) success in task fulfillment, and (viii) diminishing of incorrect actions were observed only in the main group. The Enoant use led to the positive changes of reflexivity regarding emotional-volitional and activity spheres of examinees. Thus, Enoant use increases the reserve of adaptation to psychological stress and it can be used as a countermeasure against psychological stress in personnel. Enoant may also be successfully employed in the control of psychological stress at periods of alcohol consumption restriction and under the risk of alcohol addiction development. © 2013 Springer Science+Business Media Dordrecht.

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