Creo Medical | Date: 2017-04-05
An isolating circuit for an electrosurgical resection system comprises a combining circuit (308) having a first input connectable to an RF channel (306), a second input connectable to a microwave channel (304), and an output in communication with the first and second inputs for conveying RF and microwave energy to a common signal pathway. A waveguide isolator (312) is connected to isolate the microwave energy from the RF energy. The waveguide isolator comprises a conductive input section that mates with a conductive output section to define a waveguide cavity within a volume enclosed by the input and output sections. A DC isolation barrier is arranged between the input and output sections. The combining circuit output includes a signal conductor and a ground conductor. A capacitive structure is provided between the ground conductor and the conductive input section to inhibit coupling of the RF energy and leakage of the microwave energy.
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETOPEN-01-2016-2017 | Award Amount: 3.98M | Year: 2017
SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue. This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy. By investing in efforts such as SUMCASTECs, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact. All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 .
Creo Medical | Date: 2014-12-04
An isolating circuit for electrosurgical generator arranged to produce radiofrequency (RF) energy and microwave energy for treating biological tissue. The generator has an RF channel and a microwave channel which are combined at signal combiner to enable the RF energy and microwave energy to be delivered into tissue along a common feed path. The isolating circuit comprises a tunable waveguide isolator at a junction between the microwave channel and signal combiner, and can include a capacitive structure between a ground conductor of the signal combiner and a conductive input section of the waveguide isolator to inhibit coupling of the RF energy and leakage of the microwave energy. The isolating circuit can combine into a single tunable unit all the necessary components to isolate the microwave and RF channels from one another whilst providing a high withstanding voltage.
Creo Medical | Date: 2015-12-04
A surgical spatula has a planar transmission line for carrying microwave energy formed from a sheet of a first dielectric material which has first and second conductive layers on opposite sides thereof. The surgical spatula also has a coaxial cable for delivering microwave energy to the planar transmission line. The coaxial cable has an inner conductor, an outer conductor coaxial with the inner conductor and a second dielectric material separating the inner and outer conductors. The inner and outer conductors extend beyond the second dielectric to overlap opposite surfaces of the transmission line and electrically contact the first conductive layer and second conductive layer respectively. The width of the first and second conductive layers is selected to create an impedance match between the transmission line and the coaxial cable.
Creo Medical | Date: 2016-05-11
A biopsy needle (80) having a longitudinal channel (84) formed within an inner conductor (86) of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip (82) e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 to 100 GHz) delivered to the coaxial antenna is emitted at the insertion tip. The insertion tip may be arranged to match the impedance of the coaxial antenna to a predetermined tissue impedance. The emitted radiation can be used to measure properties of or treat (e.g. ablate) tissue at the insertion tip. Needle biopsy apparatus is also disclosed, in which a microwave energy is controllably delivered to a needle from a microwave generator. The apparatus may include an impedance tuner to dynamically match the impedance of the needle with tissue at the insertion tip.
Creo Medical | Date: 2014-05-13
An electrosurgical device that is capable of both generating a plasma to perform surface coagulation and emitting a non-ionising microwave field (in the absence of plasma) to perform coagulation at a deeper level. The device comprises a probe tip that is connected to receive radiofrequency (RF) and/or microwave frequency energy from a generator, and also defines a flow path for a gas. The probe tip is adjustable between a first configuration, in which it defines a bipolar (e.g. coaxial) structure to produce a high electric field from the received RF and/or microwave frequency energy across the flow path for the gas to strike and sustain plasma and a second configuration, in which it defines an antenna structure to emit non-ionising microwave energy into tissue.
Creo Medical | Date: 2014-12-18
A surgical snare comprising a means of delivering thermal plasma on to biological tissue encircled by the snare. The snare may be cold snare, i.e. formed from insulating material, or active, i.e. connected to receive RF and/or microwave energy to be radiated into the area encircled by the snare. The surgical snare may thus deliver into biological tissue encircled by a retractable loop any one of (i) a plasma to perform surface coagulation, (ii) a non-ionising microwave field (in the absence of plasma) to perform coagulation at a deeper level, and (iii) an RF field to assist with cutting.
Creo Medical | Date: 2014-04-14
A pulsed RF cut waveform profile for electrosurgery, in which each pulse is formed of a composite of different pulse portions. The pulse includes a controllable treatment portion whose duration can be truncated as necessary to ensure that the average power delivered by the pulse as a whole does not exceed a predetermined value. A limit for the average power delivered by the composite pulse (i.e. total energy delivered over the duration of the ON and OFF portions divided by the pulse duration) may be selectable by the operator. The ON portion may have multiple sub-portions, which have different purposes. Each pulse may be automatically controlled for pulse width in this manner, so that the RF signal effectively responds intelligently to conditions at the probe tip during treatment.
Creo Medical | Date: 2014-12-30
A biopsy needle having a longitudinal channel formed within an inner conductor of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 to 100 GHz) delivered to the coaxial antenna is emitted at the insertion tip. The insertion tip may be arranged to match the impedance of the coaxial antenna to a predetermined tissue impedance. The emitted radiation can be used to measure properties of or treat (e.g., ablate) tissue at the insertion tip. Needle biopsy apparatus is also disclosed, in which a microwave energy is controllably delivered to a needle from a microwave generator. The apparatus may include an impedance tuner to dynamically match the impedance of the needle with tissue at the insertion tip.
Creo Medical | Date: 2014-12-31
An electrosurgical instrument for applying to biological tissue RF electromagnetic energy and/or microwave frequency EM energy, wherein the instrument tip has a protective hull with a smoothly contoured convex undersurface facing away from a planar body, and wherein the planar body has a tapering distal edge, and wherein an underside of the planar body extends beyond the protective hull at the tapering distal edge. Also disclosed herein is an interface joint for integrating into a single cable assembly all of (i) a fluid feed, (ii) a needle movement mechanism, and (iii) an energy feed (e.g. a coaxial cable), and a torque transfer device for permitting controlled rotation of the cable assembly within the instrument channel of an endoscope. The interface joint and torque transfer device may be integrated as a single component.