Enquist P.-A.,Umea University |
Gylfe A.,Umea University |
Hagglund U.,Creative Antibiotics |
Lindstrom P.,Creative Antibiotics |
And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2012
Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-) methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure-activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models. © 2012 Elsevier Ltd. All rights reserved.