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Beijing, China

Creat Studios, Inc. is a video game developer and publisher for sixth and seventh generation handhelds and consoles.It was founded in 1990 in Saint Petersburg, Russia. Later US office was opened in Massachusetts .At present Creat's corporate headquarters are located in Canton, Massachusetts, with development studios in Massachusetts, USA and Saint Petersburg, Russia.Creat Studios is an official developer for PlayStation Portable, PlayStation 3, Nintendo DS, Wii and Xbox 360, and is a publisher for PlayStation Network and for DSiWare. It has also developed games for Windows as well as PlayStation 2, Nintendo GameCube, and Xbox. Wikipedia.


Migraine is a primary neurovascular condition highly influenced by hormone changes. During pregnancy, seizures can take place and should therefore be treated carefully because various medicines are potentially dangerous for the mother and above all for the baby. Hence, acupuncture is a safe alternative for the treatment of the causes leading to this condition according to Chinese medicine. © 2015 Elsevier España, S.L.U. Source


Hu W.-H.,Huizhou Power Supply Company | Shu H.,Beijing Jiaotong University | Luan Y.-G.,CREAT
Dianli Xitong Baohu yu Kongzhi/Power System Protection and Control | Year: 2010

A power quality signals' de-noising method based on singular value decomposition(SVD) is proposed in this paper. A track matrix of attractor is reconstructed based on time series, then according to the singular values' percent of contribution to total energy(PCTE), disturbance signal is reconstructed, which is the de-noised power quality signal. Simulation results indicate that SVD can improve SNR and keep original disturbances' characters. The proposed algorithm's theory foundation is consummate and is easy to be carried out, so it has nice developmental foreground. Source


Fornecker L.-M.,Hopitaux Universitaires Of Strasbourg | Aurran-Schleinitz T.,Institute Paoli Calmettes | Michallet A.-S.,Center Hospitalier Lyon Sud | Cazin B.,Lille University Hospital Center | And 11 more authors.
American Journal of Hematology | Year: 2015

The optimal management of patients with relapsed chronic lymphocytic leukemia (CLL) is dictated by the type of prior therapy, duration of prior response, presence of genomic aberrations, age, and comorbidities. The patterns of relapses and the clinical outcomes of second-line options after fludarabine-cyclophosphamide-rituximab (FCR) is given as a frontline treatment are currently unknown. In this retrospective and non-randomized study, we report the outcomes of 132 patients from databases of 14 French CLL study group centers who needed a second-line treatment after FCR frontline. Bendamustine+rituximab (BR) was the most frequently used second-line regimen, followed by alemtuzumab-based regimens, R-CHOP, and FCR. Median progression-free survival (PFS) was 18 months after BR with a median overall survival (OS) not reached. We also found that response durations of<36 months and the presence of del(17p) are critical factors that contribute to poor overall survival. BR appears to be an effective salvage regimen in our series, both in terms of progression-free and overall survival. Patients who relapsed less than 36 months after FCR have a poor outcome, not significantly different in this study from patients with early relapses less than 12 or 24 months. © 2015 Wiley Periodicals, Inc. Source


Urbaczek A.C.,CREAT
Revista Internacional de Acupuntura | Year: 2015

Migraine is a primary neurovascular condition highly influenced by hormone changes. During pregnancy, seizures can take place and should therefore be treated carefully because various medicines are potentially dangerous for the mother and above all for the baby. Hence, acupuncture is a safe alternative for the treatment of the causes leading to this condition according to Chinese medicine. © 2015 Elsevier España, S.L.U. Source


Hivert B.,Center Hospitalier Schaffner | Caron C.,Lille University Hospital Center | Petit S.,Service danatomo pathologie | Charpy C.,Estaing University Hospital Center | And 10 more authors.
Blood | Year: 2012

Acquired von Willebr and syndrome is described in patients with Waldenström macroglobulinemia (WM). Assessment of ristocetin cofactor activity (VWF:RCo) and von Willebrand factor (VWF) antigen (VWF:Ag) in 72 consecutive patients with WM showed a negative relation between VWF levels < 130 U/dL and both monoclonal immunoglobulin M concentration (mIgMC) and viscosity. Ten patients with VWF:RCo < 50 U/dL (< 40 for patients with blood group O) fulfilled the acquired von Willebrand syndrome criteria. They had higher mIgMC and viscosity. Reduction in mIgMC was associated with increase in VWF levels. The low VWF:RCo VWF:Ag ratio suggested that high viscosity might be associated with increased shear force and cleavage of multimers. Surprisingly, 43 patients (59%) presented with high VWF:Ag (> 110 U dL). They had higher bone marrow microvessel density and vascular endothelial growth factor expression on bone marrow mast cells. Five-year survival rates of patients with VWF:Ag < 110, between 110 and 250, and more than 250 U/dL were 96%, 71%, and 44%, respectively (P <.0001). High VWF:Ag was also a significant adverse prognostic factor for survival after first-line therapy (P <.0001), independently of the international scoring system. These results support systematic assessment of VWF in patients with WM. The adverse prognostic value of high VWF levels raises issues on interactions between lymphoplasmacytic cells, mast cells, and endothelial cells in WM. © 2012 by The American Society of Hematology. Source

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