Woburn, MA, United States
Woburn, MA, United States

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Patent
Courtagen Life Sciences | Date: 2014-06-11

The present disclosure provides methods and kits for treating and classifying individuals at risk of or suffering from a neurological and/or mitochondrial dysfunction or disorder. In general, the individuals are treated and/or classified based on the presence of a loss-of-function mutation in nuclear DNA encoding one or more proteins selected from the group consisting of ALDH1L1, ALDH1L2, FOLR1, FPGS, GCSH, GLDC, MTHFD1, MTHFD1L, MTHFD2, MTHFD2L, MTHFS, MTRR, SHMT1, SHMT2 and SLC25A32. Treatment involves the administration of a therapeutically effective amount of folinic acid, glycine or a pharmaceutically acceptable salt thereof.


Patent
Courtagen Life Sciences | Date: 2016-11-22

The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.


WOBURN, Mass.--(BUSINESS WIRE)--Courtagen Life Sciences, Inc., an innovative endocannabinoid platform and molecular information company, announced today that the company has received a Notice of Allowance from the United States Patent and Trademark Office for its patent application no. 14/895,557, titled “Methods and Kits for Treating and Classifying Individuals at Risk of or Suffering from TRAP1 Change-of-Function.” The patent application addresses a complementary or companion diagnostic approach for a potential drug target related to a genetic form of chronic pain that may be present in approximately 1% of the population. The recently published crystal structure of the TRAP1 gene has enabled the company to conduct protein variant predictions, which have highlighted several compounds that fit within the mutated ATPase domain, including notably, cannabidiol from the hemp and cannabis plants. “We believe the future of medicine is genome-directed, and with over 90 daily fatalities due to the opioid epidemic, a genetically stratified solution to the urgent problem now can be explored,” stated Kevin McKernan, Chief Science Officer of Courtagen Life Sciences. “It’s important to reinforce that our policy is to never exert patent rights against patients. In fact, we believe this patent will allow us to accelerate method and technology development for this personalized medicine marker in a market with large incumbents, to bring a solution to patients suffering from chronic pain.” To learn more, visit Facebook, Twitter, and Instagram. Follow on social media with hashtags #Courtagen. About Courtagen Life Sciences, Inc. Courtagen Life Sciences, Inc., located in Woburn, MA, is a CLIA/CAP certified endocannabinoid platform and molecular information company focused on the diagnosis of a range of neurological, endocrine, and functional disorders associated with the central, peripheral, and autonomic nervous systems, including the endocannabinoid receptor system. Courtagen operates a highly sophisticated Next Generation DNA Sequencing, bioinformatics, and clinical interpretation business that helps physicians elucidate the linkages between the genotypes and phenotypes of various diseases, which may be treated with a host of therapies, including pharmaceutical drugs and medical cannabis. For more information, please visit http://www.courtagen.com/.


WOBURN, Mass.--(BUSINESS WIRE)--Courtagen Life Sciences, Inc., an innovative molecular information company, announced today that it has launched Avantra Genetics, a division of the company dedicated to providing advanced genomic information for functional medicine practices. Patients suffering from functional disorders may experience symptoms such as pain, fatigue, numbness or sensations and gastrointestinal distress that can be severe, chronic or debilitating. These disorders are often difficult to diagnose and treat, but may have a genetic origin or influence. “Physicians practicing functional, integrative, or naturopathic medicine have been early adopters of personalized medicine and the use of personal genetic information to help guide diet and lifestyle choices,” said Brian McKernan, CEO of Courtagen Life Sciences. “Our new Avantra Genetics tests provide genomic information focused on biological pathways important to these functional medicine clinicians.” Courtagen’s Avantra Genetics division launches two genomic information-only tests for migraines and abdominal pain, with additional tests following later this year. The tests focus on genes in pathways of interest to functional medicine clinicians who want to better understand their patients with the signs, symptoms and indications of pain. The tests cover genes associated with, but are not limited to, celiac disease and lactase deficiency for abdominal pain, and coenzyme Q10 deficiency and dystonia associated with migraines. Also included are selections of common variants reported to be associated with general wellness. These genomic informative reports provide features such as links to literature and databases for the variants identified in the individual tested. To learn more, visit Courtagen on Facebook, Twitter, and Instagram and Avantra Genetics on Facebook and Twitter. Courtagen Life Sciences, Inc., located in Woburn, MA, is a CLIA/CAP certified molecular information company focused on the diagnosis of a range of neurological, endocrine, and functional disorders associated with the central, peripheral, and autonomic nervous systems, including the endocannabinoid receptor system. Courtagen operates a highly sophisticated Next Generation DNA Sequencing, bioinformatics, and clinical interpretation business that helps physicians elucidate the linkages between the genotypes and phenotypes of various diseases, which may be treated with a host of therapies, including pharmaceutical drugs and medical cannabis. For more information, please visit http://www.courtagen.com/.


WOBURN, Mass.--(BUSINESS WIRE)--Courtagen Life Sciences, Inc., an innovative molecular endocannabinoid platform and information company, announced today that it has launched 10 new gene panels in its Spotlight line of tests. The tests will expand the company’s Spotlight menu in neurology and endocrinology, and adds to the selection of tests currently available for epilepsy, developmental delay, endocrinology, and mitochondrial disease. “We are happy to offer another expansion to our test menu in just a month since our last announcement,” stated Brian McKernan, CEO of Courtagen Life Sciences. “Our rapid development engine enables Courtagen to address the testing needs of our ordering physicians and institutions quickly. We expect to significantly expand our test offerings over the course of 2017.” The new Spotlight tests will primarily address neuromuscular disorders, such as congenital myasthenia, hereditary spastic paraplegia, congenital and limb-girdle muscular dystrophy, and myopathies, and one new endocrine disorder test for Bardet-Biedl syndrome. To learn more, visit Facebook, Twitter, and Instagram. Follow on social media with hashtags #Courtagen About Courtagen Life Sciences, Inc. Courtagen Life Sciences, Inc., located in Woburn, MA, is a CLIA/CAP certified endocannabinoid platform and molecular information company focused on the diagnosis of a range of neurological, endocrine, and functional disorders associated with the central, peripheral, and autonomic nervous systems, including the endocannabinoid receptor system. Courtagen operates a highly sophisticated Next Generation DNA Sequencing, bioinformatics, and clinical interpretation business that helps physicians elucidate the linkages between the genotypes and phenotypes of various diseases, which may be treated with a host of therapies, including pharmaceutical drugs and medical cannabis. For more information, please visit http://www.courtagen.com/.


Patent
Courtagen Life Sciences | Date: 2015-03-27

Using the efficiency of next generation sequencing, a draft de novo reference sequence for the Cannabis (C.) Sativa and C. Indica genomes has been generated as well as four full length contiguous sequences with homology to THCA and CBDA synthases and 10 partially homologous contigs with truncated ORFs. In particular aspects the invention is directed to an (one or more) isolated sequence (e.g., nucleic acid sequence, DNA, RNA, genomic sequence, polypeptide) of a Cannabis genome and uses thereof.


Patent
Courtagen Life Sciences | Date: 2016-04-14

The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.


The present disclosure provides methods and kits for treating and classifying individuals at risk of or suffering from a neurological dysfunction or disorder. In general, the individuals are treated and/or classified based on the presence of a loss-of-function mutation in nuclear DNA that encodes choline O-acetyltransferase (ChAT). Treatment involves the administration of a therapeutically effective amount of an acetylcholinesterase (ACNE) inhibitor.


The present disclosure provides methods and kits for treating and classifying individuals at risk of or suffering from a neurological and/or mitochondrial dysfunction or disorder. In general, the individuals are treated and/or classified based on the presence of a change-of-function mutation in nuclear DNA that encodes TNF receptor-associated protein 1 (TRAP1). Treatment involves the administration of a therapeutically effective amount of an antioxidant.


Patent
Courtagen Life Sciences | Date: 2014-07-25

The invention is directed to methods of removing amplicons of non target and/or target nucleic acid sequences having one or more modified (e.g., methylated) nucleotides from a sample wherein the sample comprises the non target nucleic acid and a target nucleic acid sequence to be amplified.

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