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Čakovec, Croatia

Martic A.J.,County Hospital Cakovec | Ivankovic S.,Ruder Boskovic Institute | Antica M.,Ruder Boskovic Institute | Hirsl N.,Ruder Boskovic Institute | And 2 more authors.
Cancer Biotherapy and Radiopharmaceuticals | Year: 2015

C3Hf/HZgr mice were transplanted with SCCVII carcinoma cells and treated with Newcastle disease virus (NDV). The treatment slows down the growth of transplanted tumor. Furthermore, by using specific monoclonal antibodies, the frequencies of CD4+, CD8+, and CD4+CD25+ T lymphocytes were determined in the spleen of tumorous mice at particular times following tumor transplantation and/or NDV application. The incidence of lymphocytes CD4+ and CD8+ decreased and of CD4+CD25+ increased in the spleen of mice during the time following tumor transplantation. However, the frequency of regulatory CD4+CD25+ T lymphocytes in the spleen is very low, while CD4+ and CD8+ increased to normal level following intraperitoneal (i.p.) NDV injection in tumor-bearing mice. Thus, besides directly destroying transplanted tumor, NDV seems to be involved against growing tumor by reducing the frequency of regulatory T lymphocytes maintaining the frequency of CD4+ and CD8+ T lymphocytes within the control values pointing to its role in immunomodulation. © Mary Ann Liebert, Inc. 2015.

Alfirevic Z.,University of Zagreb | Simundic A.-M.,University of Zagreb | Nikolac N.,University of Zagreb | Sobocan N.,County Hospital Cakovec | And 4 more authors.
Biochemia Medica | Year: 2010

Introduction: Venous thromboembolic disease is one of the leading causes of morbidity and mortality in the developed world. Identification of hereditary factors of thrombophilia is contributing to a better understanding of the etiology and disease prevention. The aim of this study was to assess the prevalence of factor II G20210A, factor V Leiden, MTHFR (methylenetetrahydrofolate reductase) C677T and PAI-1 (plasminogen activatorinhibitor-1) 5G/4G polymorphisms in healthy Croatian subjects and patients with thromboembolism. Materials and methods: This prospective study Included 100 thromboem bolic patients consecutively admitted to the Intensive Care Unit, Sestre Milosrdnice University Hospital and 106 healthy subjects. Genotyping of factor II G20210A, factor V Leiden, MTHFR C677T and PAI-1 5G/4G polymorphisms was done using melting curve analysis on Light Cycler 1.2 analyzer. Results: Heterozygotes for Factor V Leiden polymorphism were more frequent in the group of pa tients with the throm boembolicdi sea se (16%) than in the control healthy subjects (2.9%), OR (95% CI) = 6.41 (1.81-22.8); P = 0.004. Allele and genotype frequencies of other studied polymorphisms did not differ between cases and controls. Conclusion: This study confirmed the association of factor V Leiden polymorphism with the thromboembolic disease in Croatian population.

Zokalj I.,County Hospital Cakovec | Marotti M.,University of Zagreb | Kolaric B.,University of Rijeka | Kolaric B.,Institute Of Public Health Dr Andrija Stampar
International Urology and Nephrology | Year: 2014

Purpose: We conducted a retrospective study to evaluate the influence of different tumor enhancement measurement approaches on the ability of computed tomography (CT) to differentiate between solid forms of clear cell renal cell carcinoma (RCC), other RCC histologic subtypes and oncocytomas. Different RCC subtypes have a diverse range of malignant potential; consequently, the information about RCC subtype obtained using minimally invasive imaging method before the treatment could allow the more accurate therapy planning. Differentiation of ccRCCs from oncocytomas is important because oncocytomas are usually benign tumors which could be treated conservatively. Methods: CT images of 113 patients with 118 solid renal tumors were evaluated. The imaging protocol consisted pre-contrast and post-contrast images during the arterial and nephrographic phases. Renal tumor attenuation values were measured using region of interest covering as much of the solid enhancing tumor tissue as possible. Tumor attenuation values and tumor enhancement ratios were correlated with histologic subtype. One hundred of tumors were diagnosed as clear cell RCC, nine as non-clear cell RCC and nine as oncocytoma. Results: Tumor attenuation values of >74 HU on the arterial phase scans significantly correlated with clear cell RCC (Az 0.73). The tumor-to-aorta enhancement ratios calculated on tumor attenuation values measured on the arterial phase scans had a cutoff value of >0.29, which significantly correlated with clear cell RCC (Az 0.79). All ROC curves for differentiating the clear cell RCC from oncocytomas have area under the curve too small (0.5 or less) to have chose cutoff value with sensitivity and specificity that could be applied in clinical work. Conclusion: Enhancement measurements of renal carcinomas on CT images in the arterial phase can be used as an auxiliary method in the pretreatment differentiation of solid forms of the most frequent RCC subtypes in patients not suitable for core biopsy but who are suitable for minimally invasive treatment methods and/or targeted therapy. © 2013 Springer Science+Business Media.

Mustapic J.,Center for Diagnostics in Zagreb | Marcinko D.,University of Zagreb | Vargek P.,County Hospital Cakovec
Eating and Weight Disorders | Year: 2015

Purpose: Numerous studies are conducted to investigate factors influencing eating and weight-related problems, given the alarming prevalence of such behaviours among adolescents. The relationship between shame, especially body shame, and eating disorders has received increased attention in recent years. The current study contributes to this field by exploring body shame as a potential mediator of the relationship between body dissatisfaction and eating behaviours among adolescent girls, while controlling for age and body mass index (BMI). Methods: The participants, 187 adolescent girls from three secondary schools in Zagreb, completed self-report measures of demographic, eating behaviours, body satisfaction and body shame. Results: Body shame and body dissatisfaction explained statistically significant amount of eating behaviours variance, while controlling for age and BMI. Further, body shame partially mediated the relationship between body dissatisfaction and eating behaviours. Conclusions: This study provides further evidence of the experience of body shame among adolescent girls and suggests that this shame is associated with disordered eating behaviours. Future longitudinal research designed to specifically explore body shame and other potentially shared risk factors is needed, and would enhance our understanding of eating disorder aetiology. © 2015, Springer International Publishing Switzerland.

Dilber D.,County Hospital Cakovec | Cerkez-Habek J.,County Hospital Cakovec | Baric H.,Medimurje County Institute for Emergency Medicine | Gradiser M.,University of Zagreb
Saudi Medical Journal | Year: 2015

Atrial fibrillation (AF) is the most common arrhythmia and it is an independent risk for serious events. Acupuncture has been growing in popularity in the West, and there are reports of its benefits in treating AF. We report a 57-year-old man who was admitted after having an allergic reaction to amiodarone administered to treat paroxysmal AF with fast ventricular response. Cardioversion with intravenous propafenone was uneventful. Before an attempt of electric cardioversion, he was treated with acupuncture as additional therapy to peroral propafenone. After acupuncture treatment consisting of 10 treatments during 30 days period, both immediate cardioversion to sinus rhythm and no paroxysmal AF during 30 days period were recorded. © 2015, Saudi Arabian Armed Forces Hospital. All rights reserved.

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