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Tshweu L.,Council for Scientific and Industrial Research Materials Science and Manufacturing | Katata L.,Council for Scientific and Industrial Research Materials Science and Manufacturing | Katata L.,North West University South Africa | Kalombo L.,Council for Scientific and Industrial Research Materials Science and Manufacturing | And 7 more authors.
Nanomedicine | Year: 2014

Aim: To encapsulate efavirenz (EFV) within poly(epsilon-caprolactone) (PCL) nanoparticles (NPs) and compare the oral pharmacokinetics with that of EFV-loaded micelles and pure EFV NPs. Materials & methods: EFV-loaded PCL NPs were produced by a double-emulsion/spray-drying method. Results: NPs displayed a hydrodynamic diameter of 200-250 nm. The encapsulation efficiency was 86-93% and the mass recovery was above 60%. X-ray diffraction indicated that drug and PCL underwent amorphization during the spray-drying process. Encapsulation within NPs significantly increased the maximum concentration in plasma and the bioavailability. Conclusion: EFV-loaded PCL NPs represent a promising platform to develop scalable pharmaceuticals with improved (bio)pharmaceutic performance. © 2014 Future Medicine Ltd.

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