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Ahmed N.,Quaid-i-Azam University | Mahmood A.,Quaid-i-Azam University | Tahir S.S.,Pakistan Council for Scientific and Industrial Research | Bano A.,Quaid-i-Azam University | And 3 more authors.
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Ethnomedicinal studies are significant for the discovery of new crude drugs from indigenous reported medicinal plants. The current study aimed to report the indigenous medicinal knowledge of plants and herbal remedies used as folk medicines in Cholistan desert, Punjab Province, Pakistan. Material and methods Rapid appraisal approach (RAA), semi-structured interviews, group meetings with herbalists, landowners and local people having awareness about the medicinal action of plants were employed to collect the data. Results and discussions This study reports 70 medicinal plants belonging to 27 families that were disseminated among 60 different genera and Poaceae was the predominant family over others with 13 reported medicinal plants. Among plant parts, leaves were the dominant over others with 26.4% used in herbal preparations followed by the stem (25.2%), fruit (21.5%), flower (16.3%), seed (6.5%), bark and pod (02%). Haloxylon recurvum exhibited the highest use vale (UV) 0.83 while least UV was exhibited by Mollugo cerviana that was 0.16. Conclusion Important medicinal plants, reported in this study have been screened for phytochemical and pharmaceutical activities in different parts of the globe. It is recommended that reported medicinal plants having potent action for cancer and hepatitis must be screened for pharmacological activities. © 2014 Elsevier Ireland Ltd. Source


Ahmed N.,Quaid-i-Azam University | Mahmood A.,University of Sargodha | Mahmood A.,Quaid-i-Azam University | Tahir S.S.,Pakistan Council for Scientific and Industrial Research | And 4 more authors.
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Ethnomedicinal reports are important for the discovery of new crude drugs from reported medicinal plants with high use value. The current study aimed to document the medicinal flora as well as medicinal knowledge of indigenous plants of local communities from Layyah district, Punjab Province, Pakistan. Material and methods Rapid appraisal approach (RAA), semi-structured interviews, group meetings with herbalists, landowners and local people having awareness about the medicinal action of plants were employed to collect the data. Use values (UV) and frequency of citation (FC) were calculated to check the relative importance of plants. Results and discussions The current ethnomedicinal study reported 125 medicinal plant species diversified from 106 genus belonging to the 43 different families and Poaceae was the predominant family over others with 16 reported medicinal plants. Wild herbaceous plants were the predominant over other life forms while among plant parts, leaves contributed 32% followed by the stem (27%), fruit and flowers (15%). Allium sativum exhibited the highest use vale (UV) 0.92 while the lowest UV was exhibited by Lasiurus scindicus which was 0.15. Conclusion Local communities of district Layyah still have a strong faith on herbal medicines for basic healthcare needs. Indigenous plants having high UV and FC should be subjected to the detailed phytochemical investigations to explore new natural drugs. © 2014 Elsevier Ireland Ltd. All rights reserved. Source


Ahmed Baig J.,University of Sindh | Gul Kazi T.,University of Sindh | Qadir Shah A.,University of Sindh | Abbas Kandhro G.,University of Sindh | And 4 more authors.
Ecotoxicology and Environmental Safety | Year: 2010

The principal object of the current study was to estimate total arsenic and its inorganic speciation in different origins of surface water (n=480) and groundwater (n=240) of Sindh, Pakistan. This study provided a description based on the evaluation of physico-chemical parameters of collected water samples and possible distribution of As with respect to its speciation. The concentration of total inorganic As (iAs) and its species (As3+ and As5+) for the surface and underground water was reported in terms of basic statistical parameters, principal component analysis, cluster analysis, metal-to-metal correlations and linear regression analyses. The chemical correlations were observed by PCA, which were used to classify the samples by CA, based on the PCA scores. Standard addition method confirmed the accuracy; the recoveries of As3+ and iAs were found to be >98%. The concentration of As5+ in the water samples was calculated by the difference of the total inorganic arsenic and As3+. The results revealed that the groundwater of the understudied area was more contaminated as compared to the surface water samples. The mean concentration of As3+ and As5+ in the surface water and groundwater samples were in the range 3.0 to 18.3 and 8.74-352γg/L, respectively. © 2010 Elsevier Inc. Source


Naeem M.,Pakistan Council for Scientific and Industrial Research | Muhammad Nawaz Ch.,University of Punjab | Rehaman S.,Pakistan Council for Scientific and Industrial Research | Amjad R.,Pakistan Council for Scientific and Industrial Research
Asian Journal of Chemistry | Year: 2012

Novel compounds of series 1a-j and 2a-j were synthesized by adopting environment friendly methodology, with an idea that these compounds are tested for their antibacterial activity. In combination to microwave radiation with montmorillonite clays (K10 and KSF types) were used as solid phase catalysts. The catalytic efficiency of montmorillonite KSF was marginally inferior to that of montmorillonite K10. The average yield of all compounds of (1a-j) was found 88.3 and 88.5 % for the compounds (2a-j). Structural elucidation was carried out using FTIR, 1H NMR, elemental analyzer and MS. The synthesized compounds were checked for their antibacterial activity (in vivo) and found that the compounds 1g, 1h, 2g and 2j exhibited comparable or higher antibacterial activity then reference standard against E. coli, S. enteritidis, P. aeruginosa, S. aureus and B. subtilis. Most of the compounds of series-2 showed significant activity as compared with ciprofloxacin. These compounds could be lead to the selection and use as efficient antimicrobial agents, especially for the treatment of multi-drug resistant infections. Source

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