2011 Cosmetic Ingredient Review Expert Panel member

United States

2011 Cosmetic Ingredient Review Expert Panel member

United States
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Burnett C.L.,Scientific Analyst Writer | Bergfeld W.F.,2011 Cosmetic Ingredient Review Expert Panel member | Belsito D.V.,2011 Cosmetic Ingredient Review Expert Panel member | Hill R.A.,2011 Cosmetic Ingredient Review Expert Panel member | And 6 more authors.
International Journal of Toxicology | Year: 2012

Cocamidopropyl betaine (CAPB) and related amidopropyl betaines are zwitterions used mainly as surfactants in cosmetics. These cosmetic ingredients are similar in their chemistry, in particular with respect to the presence of 3,3-dimethylamino-propylamine (DMAPA) and fatty acid amidopropyl dimethylamine (amidoamine) impurities, which are known as sensitizers. The CIR Expert Panel concluded that because these ingredients present no other significant toxicity, when formulated to be nonsensitizing (which may be based on a quantitative risk assessment), these ingredients are safe for use as cosmetic ingredients in the practices of use and concentration of this safety assessment. © 2012, SAGE Publications. All rights reserved.


Fiume M.M.,Scientific Analyst Writer | Eldreth H.,Cosmetic Ingredient Review | Bergfeld W.F.,2011 Cosmetic Ingredient Review Expert Panel member | Belsito D.V.,2011 Cosmetic Ingredient Review Expert Panel member | And 7 more authors.
International Journal of Toxicology | Year: 2012

The CIR Expert Panel assessed the safety of dicarboxylic acids and their salts and esters as used in cosmetics. Most dicarboxylic acids function in cosmetics as pH adjusters or fragrance ingredients, but the functions of most of the salts in cosmetics are not reported. Some of the esters function as skin conditioning or fragrance ingredients, plasticizers, solvents, or emollients. The Expert Panel noted gaps in the available safety data for some of the dicarboxylic acid and their salts and esters in this safety assessment. The available data on many of the ingredients are sufficient, however, and similar structural activity relationships, biologic functions, and cosmetic product usage suggest that the available data may be extrapolated to support the safety of the entire group. The Panel concluded that the ingredients named in this report are safe in the present practices of use and concentration. © 2012, SAGE Publications. All rights reserved.

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