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Becker L.C.,Cosmetic Ingredient Review Scientific Analyst Writer | Bergfeld W.F.,Cosmetic Ingredient Review Expert Panel Member | Belsito D.V.,Cosmetic Ingredient Review Expert Panel Member | Hill R.A.,Cosmetic Ingredient Review Expert Panel Member | And 7 more authors.
International journal of toxicology | Year: 2015

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of 16 pentaerythrityl tetraester compounds as used in cosmetics. These ingredients mostly function as hair-conditioning agents, skin-conditioning agents-miscellaneous and binders, skin-conditioning agents-occlusive, viscosity-increasing agents-nonaqueous, and skin-conditioning agents-emollient. The Panel reviewed the available animal and human data related to these ingredients and previous safety assessments of the fatty acid moieties. The Panel concluded that pentaerythrityl tetraisostearate and the other pentaerythrityl tetraester compounds were safe in the practices of use and concentration as given in this safety assessment. © The Author(s) 2015. Source


Fiume M.M.,Cosmetic Ingredient Review Senior Scientific Analyst Writer | Heldreth B.A.,Cosmetic Ingredient Review Chemist | Bergfeld W.F.,Cosmetic Ingredient Review Expert Panel Member | Belsito D.V.,Cosmetic Ingredient Review Expert Panel Member | And 8 more authors.
International journal of toxicology | Year: 2015

The Cosmetic Ingredient Review Expert Panel (Panel) assessed the safety of 237 alkyl esters for use in cosmetics. The alkyl esters included in this assessment have a variety of reported functions in cosmetics, with skin-conditioning agent being the most common function. The Panel reviewed available animal and clinical data in making its determination of safety on these ingredients, and where there were data gaps, similarity in structure, properties, functions, and uses of these ingredients allowed for extrapolation of the available toxicological data to assess the safety of the entire group. The Panel concluded that these ingredients are safe in cosmetic formulations in the present practices of use and concentration when formulated to be nonirritating. © The Author(s) 2015. Source


Johnson W.,Jr. | Heldreth B.,Cosmetic Ingredient Review Chemist | Bergfeld W.F.,Cosmetic Ingredient Review Expert Panel Member | Belsito D.V.,Cosmetic Ingredient Review Expert Panel Member | And 8 more authors.
International journal of toxicology | Year: 2015

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) reviewed the safety of alkyl polyethylene glycol (PEG) sulfosuccinates, which function in cosmetics mostly as surfactants/cleansing agents. Although these ingredients may cause ocular and skin irritation, dermal penetration is unlikely because of the substantial polarity and molecular size of these ingredients. The Panel considered the negative oral carcinogenicity and reproductive and developmental toxicity data on chemically related laureths (PEG lauryl ethers) and negative repeated dose toxicity and skin sensitization data on disodium laureth sulfosuccinate supported the safety of these alkyl PEG sulfosuccinates in cosmetic products, but. The CIR Expert Panel concluded that the alkyl PEG sulfosuccinates are safe in the present practices of use and concentration when formulated to be nonirritating. © The Author(s) 2015. Source


Burnett C.,Cosmetic Ingredient Review Scientific Analyst Writer | Heldreth B.,Cosmetic Ingredient Review Chemist | Bergfeld W.F.,Cosmetic Ingredient Review Expert Panel Member | Belsito D.V.,Cosmetic Ingredient Review Expert Panel Member | And 7 more authors.
International journal of toxicology | Year: 2014

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of nylon polymers, which function in cosmetics primarily as bulking and opacifying agents. The Panel reviewed relevant animal and human data related to these large polymers and determined that they are not likely to penetrate the skin. Whatever residual monomers may be present were not present at a sufficient level to cause any reactions in test subjects at the maximum ingredient use concentration. Accordingly, the Panel concluded that these ingredients are safe in the present practices of use and concentration. © The Author(s) 2014. Source


Burnett C.,Cosmetic Ingredient Review Scientific Analyst Writer | Heldreth B.,Cosmetic Ingredient Review Chemist | Bergfeld W.F.,Cosmetic Ingredient Review Expert Panel Member | Belsito D.V.,Cosmetic Ingredient Review Expert Panel Member | And 7 more authors.
International journal of toxicology | Year: 2014

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of animal- and plant-derived amino acid mixtures, which function as skin and hair conditioning agents. The safety of α-amino acids as direct food additives has been well established, based on extensive research through acute and chronic dietary exposures and the Panel previously has reviewed the safety of individual α-amino acids in cosmetics. The Panel focused its review on dermal irritation and sensitization data relevant to the use of these ingredients in topical cosmetics. The Panel concluded that these 21 ingredients are safe in the present practices of use and concentration as used in cosmetics. © The Author(s) 2014. Source

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