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Yan S.-H.,Changzhou University | Zhang W.,Changzhou University | Shen W.,Corning China Shanghai Regional Headquarters | Shen J.-F.,Changzhou University | And 3 more authors.
Gao Xiao Hua Xue Gong Cheng Xue Bao/Journal of Chemical Engineering of Chinese Universities | Year: 2014

Epichlorohydrin is usually produced via the alkalic cyclization of dichloropropanol in tower reacting systems. In order to improve the continuous control and productivity of the reaction system, a new continuous process was designed by using a micro-channel reactor with pulse mixing structure. Dichloropropanol was used as the starting material, and the influences of different factors including reactants ratio, reacting temperature, residence time and alkali liquor concentration were investigated. Experimental results show that when an optimized condition, i. e. n(NaOH):n(Dichloropropanol) = 1.1: 1, reacting temperature of 60°C, residence time of 10s, NaOH concentration of 20%(wt) is used, the conversion of dichloropropanol can reach to 99.6% with a yield of 98.5%. Compared with traditional tower reacting processes, the yield is higher with less reacting time in the new micro-channel reacting process. The results show that the structure of the micro-channel has observable effects on the cyclization reaction. Less raw material consumption, higher product yield and superior reactor productivity are achieved in the continuous process with the pulse mixing channel reacting system.

Gu J.,Beijing Laviana Pharmatech Co. | Wang M.-X.,Beijing Laviana Pharmatech Co. | Chen W.-T.,Beijing Laviana Pharmatech Co. | Zhou Y.,Beijing Laviana Pharmatech Co. | And 5 more authors.
Xiandai Huagong/Modern Chemical Industry | Year: 2012

Corning continuous-flow microchannel reactor G1 has been applied to upgrade a conventional HATP batch process. The effects of solvent, temperature, molar ratio, and retention time are investigated. The purity and the yield of targeted products obtained from optimized process are about 98% and 100%, respectively. The compact design of G1 reactor can be installed in normal fume hood of chemical synthesis lab, and deliver about 30 t/y HATP product capability. More importantly, it is a green chemistry process and can achieve "zero effluent" objectives.

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