Ithaca, NY, United States

Cornell University
Ithaca, NY, United States

Cornell University is an American private Ivy League and federal land-grant research university located in Ithaca, New York. Founded in 1865 by Ezra Cornell and Andrew Dickson White, the university was intended to teach and make contributions in all fields of knowledge — from the classics to the science, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's motto, a popular 1865 Ezra Cornell quotation: "I would found an institution where any person can find instruction in any study."The university is broadly organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its own admission standards and academic programs in near autonomy. The university also administers two satellite medical campuses, one in New York City and one in Education City, Qatar. Cornell is one of three private land grant universities. Of its seven undergraduate colleges, three are state-supported statutory or contract colleges, including its agricultural and veterinary colleges. As a land grant college, it operates a cooperative extension outreach program in every county of New York and receives annual funding from the State of New York for certain educational missions. The Cornell University Ithaca Campus comprises 745 acres, but in actuality, is much larger due to the Cornell Plantations as well as the numerous university owned lands in New York.Since its founding, Cornell has been a co-educational, non-sectarian institution where admission is offered irrespective of religion or race. Cornell counts more than 245,000 living alumni, 34 Marshall Scholars, 29 Rhodes Scholars and 44 Nobel laureates as affiliated with the university. The student body consists of nearly 14,000 undergraduate and 7,000 graduate students from all 50 American states and 122 countries. Wikipedia.

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Cornell University and University of Washington | Date: 2017-01-25

The disclosure provides methods of preventing heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of aromatic-cationic peptide to subjects in need thereof.

Disclosed herein are compositions that have substantially purified Christensenellaceae bacteria, and uses of these compositions to alter the microbiome of an individual. The addition of Christensenellaceae bacteria, such as Christensenella, to the microbiome of an individual can treat or prevent weight gain, reduce body weight, inhibit fat accumulation, reduce excess adiposity, and reduce a high body mass index (BMI), and can also treat or prevent conditions correlating with excess weight and fat and a high BMI, such as insulin sensitivity, metabolic syndrome, excess adiposity, and diabetes.

Cornell University and Sloan Kettering Institute For Cancer Research | Date: 2017-02-08

The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double- stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

This invention relates to pharmaceutical composition and methods of using vitamin A and/or RAR agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.

A hybrid additive manufacturing approach that incorporates three-dimensional (3D) printing and placement of modules selected from a library of modules to fabricate an electromechanical assembly. By virtue of fabrication of the electromechanical assembly, mechanical properties and electrical properties of the assembly are created. The invention overcomes the material and process limitations of current printable electronics approaches, enabling complete, complex electromechanical assemblies to be fabricated.

The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.

Cornell University, Gudas, Tang, Osei Sarfo and Urvalek | Date: 2017-01-18

This invention relates to pharmaceutical composition and methods of using RXR agonist and/or RAR agonist for the treatment or prevention of head and neck cancer.

Cornell University | Date: 2017-03-08

The present disclosure relates to, inter alia, a green technology for crosslinking protein molecules for various uses, where the protein molecules can be contained in protein fibers such as, but not limited to, human hair, animal fibers, and mixtures thereof. In one aspect, the present disclosure relates to a crosslinking agent comprising an oxidized sugar having at least two aldehyde groups. In another aspect, the present disclosure relates to a method of crosslinking protein fibers. This method involves providing the aforementioned crosslinking agent and infiltrating a plurality of non-crosslinked protein fibers with the crosslinking agent under conditions effective to cause protein molecules contained in the non-crosslinked protein fibers to become crosslinked, thereby yielding a population of crosslinked protein fibers.

Casey B.J.,Cornell University
Annual Review of Psychology | Year: 2015

Adolescence is the transition from childhood to adulthood that begins around the onset of puberty and ends with relative independence from the parent. This developmental period is one when an individual is probably stronger, of higher reasoning capacity, and more resistant to disease than ever before, yet when mortality rates increase by 200. These untimely deaths are not due to disease but to preventable deaths associated with adolescents putting themselves in harm's way (e.g., accidental fatalities). We present evidence that these alarming health statistics are in part due to diminished self-control-the ability to inhibit inappropriate desires, emotions, and actions in favor of appropriate ones. Findings of adolescent-specific changes in self-control and underlying brain circuitry are considered in terms of how evolutionarily based biological constraints and experiences shape the brain to adapt to the unique intellectual, physical, sexual, and social challenges of adolescence. © 2015 by Annual Reviews. All rights reserved.

Locasale J.W.,Cornell University
Nature Reviews Cancer | Year: 2013

One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine. © 2013 Macmillan Publishers Limited.

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