Ithaca, NY, United States

Cornell University
Ithaca, NY, United States

Cornell University is an American private Ivy League and federal land-grant research university located in Ithaca, New York. Founded in 1865 by Ezra Cornell and Andrew Dickson White, the university was intended to teach and make contributions in all fields of knowledge — from the classics to the science, and from the theoretical to the applied. These ideals, unconventional for the time, are captured in Cornell's motto, a popular 1865 Ezra Cornell quotation: "I would found an institution where any person can find instruction in any study."The university is broadly organized into seven undergraduate colleges and seven graduate divisions at its main Ithaca campus, with each college and division defining its own admission standards and academic programs in near autonomy. The university also administers two satellite medical campuses, one in New York City and one in Education City, Qatar. Cornell is one of three private land grant universities. Of its seven undergraduate colleges, three are state-supported statutory or contract colleges, including its agricultural and veterinary colleges. As a land grant college, it operates a cooperative extension outreach program in every county of New York and receives annual funding from the State of New York for certain educational missions. The Cornell University Ithaca Campus comprises 745 acres, but in actuality, is much larger due to the Cornell Plantations as well as the numerous university owned lands in New York.Since its founding, Cornell has been a co-educational, non-sectarian institution where admission is offered irrespective of religion or race. Cornell counts more than 245,000 living alumni, 34 Marshall Scholars, 29 Rhodes Scholars and 44 Nobel laureates as affiliated with the university. The student body consists of nearly 14,000 undergraduate and 7,000 graduate students from all 50 American states and 122 countries. Wikipedia.

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Cornell University, Gudas, Tang, Osei Sarfo and Urvalek | Date: 2017-01-18

This invention relates to pharmaceutical composition and methods of using RXR agonist and/or RAR agonist for the treatment or prevention of head and neck cancer.

This invention relates to pharmaceutical composition and methods of using vitamin A and/or RAR agonist for the treatment or prevention of diseases or conditions associated with high fat diet and/or vitamin deficiency.

The present disclosure provides methods and compositions for preventing or treating MV-induced or disuse-induced skeletal muscle infirmities in a mammalian subject. The methods further include administering to the subject an effective amount of an aromatic-cationic peptide.

A hybrid additive manufacturing approach that incorporates three-dimensional (3D) printing and placement of modules selected from a library of modules to fabricate an electromechanical assembly. By virtue of fabrication of the electromechanical assembly, mechanical properties and electrical properties of the assembly are created. The invention overcomes the material and process limitations of current printable electronics approaches, enabling complete, complex electromechanical assemblies to be fabricated.

Cornell University and University of Washington | Date: 2017-01-25

The disclosure provides methods of preventing heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of aromatic-cationic peptide to subjects in need thereof.

Cornell University and Sloan Kettering Institute For Cancer Research | Date: 2017-02-08

The present invention is directed to methods of prognosing, treating, or managing treatment of cancer in a subject. These methods involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes, recovering the exosomes from the sample, and isolating the double-stranded DNA from within the exosomes. The isolated double-stranded DNA is then used to detect the presence or absence of one or more genetic mutations associated with cancer, quantify the amount of isolated double-stranded DNA from the recovered exosomes in the sample, detect the methylation status of the isolated double- stranded DNA, or quantify the amount isolated double-stranded DNA able to enter a recipient cell. The prognosing, treating, or managing treatment is carried out based on this information.

Casey B.J.,Cornell University
Annual Review of Psychology | Year: 2015

Adolescence is the transition from childhood to adulthood that begins around the onset of puberty and ends with relative independence from the parent. This developmental period is one when an individual is probably stronger, of higher reasoning capacity, and more resistant to disease than ever before, yet when mortality rates increase by 200. These untimely deaths are not due to disease but to preventable deaths associated with adolescents putting themselves in harm's way (e.g., accidental fatalities). We present evidence that these alarming health statistics are in part due to diminished self-control-the ability to inhibit inappropriate desires, emotions, and actions in favor of appropriate ones. Findings of adolescent-specific changes in self-control and underlying brain circuitry are considered in terms of how evolutionarily based biological constraints and experiences shape the brain to adapt to the unique intellectual, physical, sexual, and social challenges of adolescence. © 2015 by Annual Reviews. All rights reserved.

Artis D.,Cornell University | Spits H.,University of Amsterdam
Nature | Year: 2015

The innate immune system is composed of a diverse array of evolutionarily ancient haematopoietic cell types, including dendritic cells, monocytes, macrophages and granulocytes. These cell populations collaborate with each other, with the adaptive immune system and with non-haematopoietic cells to promote immunity, inflammation and tissue repair. Innate lymphoid cells are the most recently identified constituents of the innate immune system and have been the focus of intense investigation over the past five years. We summarize the studies that formally identified innate lymphoid cells and highlight their emerging roles in controlling tissue homeostasis in the context of infection, chronic inflammation, metabolic disease and cancer. © 2015 Macmillan Publishers Limited. All rights reserved.

Locasale J.W.,Cornell University
Nature Reviews Cancer | Year: 2013

One-carbon metabolism involving the folate and methionine cycles integrates nutritional status from amino acids, glucose and vitamins, and generates diverse outputs, such as the biosynthesis of lipids, nucleotides and proteins, the maintenance of redox status and the substrates for methylation reactions. Long considered a 'housekeeping' process, this pathway has recently been shown to have additional complexity. Genetic and functional evidence suggests that hyperactivation of this pathway is a driver of oncogenesis and establishes a link to cellular epigenetic status. Given the wealth of clinically available agents that target one-carbon metabolism, these new findings could present opportunities for translation into precision cancer medicine. © 2013 Macmillan Publishers Limited.

Sung C.H.,Cornell University
Nature cell biology | Year: 2013

Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.

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