PubMed | University College Cork, Mercy University Hospital Cork, Cork University Hospital Cork and Trinity College Dublin
Type: | Journal: Frontiers in physiology | Year: 2016
Multiple Sclerosis (MS), an idiopathic progressive immune-mediated neurological disorder of the central nervous system (CNS), is characterized by recurrent episodes of inflammatory demyelination and consequent axonal deterioration. It accounts for functional deterioration and lasting disability among young adults. A body of literature demonstrates that physical activity counteracts fatigue and depression and may improve overall quality of life in MS patients. Furthermore, much data indicates that exercise ameliorates chronic neuroinflammation and its related pathologies by tipping cytokine profiles toward an anti-inflammatory signature. Recent data has focused on the direct impact of exercise training on the innate immune system by targeting toll-like receptors (TLRs), signaling pattern recognition receptors that govern the innate immune response, shedding light on the physiological role of TLRs in health and disease. Indeed, TLRs continue to emerge as players in the neuroinflammatory processes underpinning MS. This review will highlight evidence that physical activity and exercise are potential immunomodulatory therapies, targeting innate signaling mechanism(s) to modulate MS symptom development and progression.
PubMed | University of Exeter, Oxford Genetics and Cork University Hospital Cork
Type: Journal Article | Journal: Clinical case reports | Year: 2015
In infants, especially with novel previously undescribed mutations of the KATP channel causing neonatal diabetes, invitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.
Farkhad R.I.,Cork University Hospital Cork |
O'Sullivan S.T.,Cork University Hospital Cork |
O'shaughnessy M.,Cork University Hospital Cork
Pakistan Journal of Medical and Health Sciences | Year: 2016
This study reviewed 46 patients retrospectively following repair of isolated, sharp digital nerve injury. All nerves were repaired during the period October 2003 and September 2005 with a follow-up ranging between 6 and 18 months. In this clinical study, 24 were treated by controlled mobilisation postoperatively over a period of four weeks while 22 were treated by immobilization postoperatively over a same period. Return to work, cold sensitivity, scar sensitivity, 2 point discrimination, range of motion, grip strength, differentiation between sharp and dull objects and differentiation between hot and cold objects were used as indicators of digital nerve recovery.