Cirencester, United Kingdom
Cirencester, United Kingdom

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Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Proof of Concept | Award Amount: 100.00K | Year: 2012

Clinical studies have shown that hip resurfacings provide improved patient function over total hip replacements (THR) with reduced recovery times; however, since 2008 there has been a large fall in the number of resurfacings performed. This is due to concern over ion release from metal-on-metal (MoM) implants leading to ALVAL (aseptic lymphocytedominated vasculitis associated lesion, also termed pseudotumors) and chromosomal changes.The aim of this project is to develop a metal-on-polymer (MoP) bearing couple on a large diameter resurfacing device. The MoP bearing couple consists of an acetabular component assembled from an innovative metal shell and polymer liner, and a metal femoral head. ECiMa (vitamin E cold irradiated mechanically annealed) is a next generation advanced bearing developed by Corin and Massachusetts General Hospital, and is proven to be a low wearing polymer with enhanced fatigue resistance. ECiMa is currently used as a bearing surface in THRs. This project will combine the current technical advances in polymer bearings with the clinical benefits of resurfacing to produce a next generation device suitable for young, active patients. The innovative MoP hip resurfacing will have a direct positive impact, especially on younger patients for the treatment of arthritis. Lower wear rates, improved function, increased range of motion and a return to an active lifestyle, mean that a resurfacing procedure is preferential to THR for sections of the patient demographic. Patients thought to benefit from hip resurfacing, but not currently recommended for a MoM device as they are considered at high risk from metal ion release, will be able to take advantage of the bone conserving treatment. The device will help address the NHS drive for an eighteen week referral to a treatment admitted pathway as hip resurfacings have a shorter recovery time and so can help reduce the current backlog of orthopaedics waiting times.


Patent
CORIN Ltd | Date: 2013-09-27

Leg alignment apparatus for use in total arthroplasty of left and right knees, comprises an intramedullary rod, a femoral body for location on or adjacent to an anterior surface of a femur, and a support element which extends or is extendable from the femoral body to the intramedullary rod for holding the femoral body stationary or substantially stationary relative to the intramedullary rod. A condylar locator which is pivotable relative to the femoral body and which is seatable on a distal end of the femur is also provided, along with a soft-tissue tensioning element to apply a separation between the femur and the tibia, and a varus/valgus indicator to indicate an angular alignment of the knee based on the intramedullary rod and the soft-tissue tensioning element. A method of determining a distal end resection position for a femur at a knee joint is also provided.


Patent
CORIN Ltd | Date: 2011-07-20

An acetabular cup comprises an outer shell preferably having a first tensile modulus, an inner liner preferably having at least a second tensile modulus which is greater than that of the said first tensile modulus, and at least one reinforcing element which extends from a polar region of the outer shell along a, preferably interior, surface of the outer shell. Preferably, a wall thickness of the outer shell at a region of intersection between a part-spherical portion and a frusto-conical portion of the outer shell is less at the part-spherical portion than at the frusto-conical portion. The reinforcing element has a longitudinal extent which improves the rigidity of the wall at at least the part-spherical portion.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Proof of Market | Award Amount: 25.00K | Year: 2013

Awaiting Public Project Summary


Patent
Corin Ltd | Date: 2016-01-14

A method of pre-operatively determining the suitability of a joint for a surgical corrective procedure, the method comprising the steps of: determining a patients joint orientation in a plurality of situations; determining a patient kinematic range of the patient joint based on the said joint orientations; comparing the determined patient kinematic range to a preferred kinematic range; and determining that the joint is suitable for a first surgical corrective procedure if the patient kinematic range falls within the preferred kinematic range, else determining that the joint is suitable for a second surgical corrective procedure which is different from the said first surgical corrective procedure. A device for the determination of the patient kinematic range is also provided.


Patent
Corin Ltd | Date: 2016-01-14

A method for aligning a patient implant, the method comprising the steps of: generating a digital implant model of the patient implant; determining a desired alignment of the patient implant based on predetermined alignment data; imaging an operative area of the patient to create patient-specific implant reference data; creating a virtual overlay of the digital implant model in the determined desired alignment relative to the patient-specific implant reference data; and operatively aligning the patient implant using the virtual overlay. A patient implant system to implement the method is also provided.


Patent
CORIN Ltd | Date: 2012-10-19

A femoral sizing jig for use in total arthroplasty of left and right knees, comprises a femoral body, an external-rotation-angle arm which is, preferably pivotable, relative to the femoral body for setting an external angular rotation of a left or right femur, at least one of a cutting-jig guide and a cutting jig which is, preferably slidable, relative to the femoral body and in unison with movement of the external rotation-angle arm, and a medial posterior-condylar locator which is movable in unison with the movement of the external-rotation-angle arm, so as to maintain a fixed or substantially fixed relative distance with a medial side of the at least one of a cutting-jig guide and a cutting jig. A posterior-referencing femur resecting system using said femoral sizing jig and a method of resecting a femur at a knee joint relative to the medial posterior condyle are also provided.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 139.04K | Year: 2013

Additive Manufacture (AM) is being increasingly investigated within the orthopaedic industry for the production of optimised implant designs. The technology enables complex geometries to be generated which can also be better matched to the properties of bone. Such implants can minimise bone resorbtion and facilitate improved bone ingrowth, thus improving the survivorship of the joint replacement. To date, only one US company is known to have brought AM technology to market. One of the key hurdles to enable commercialisation of existing AM designs is cleaning. Post-manufacture cleaning is required to remove unsintered material/entrapped powder and manufacturing lubricants and it is ultimately of importance to ensure patient safety. Cleaning poses a significant challenge due to the complex, porous implant geometries created by AM. The objective of this project is to develop cleaning methods to enable commercialisation of existing device designs and custom implants.


Grant
Agency: Cordis | Branch: FP7 | Program: BSG-SME | Phase: SME-2011-1 | Award Amount: 1.43M | Year: 2012

Flexible medical instruments such as bone reamers are currently constructed from multiple parts in dissimilar materials, which have very different properties. The current method of linking these parts together is by mechanical coupling. Effective decontamination of such instruments is challenging but is critical to avoid cross infection between patients. The geometry of the instrument assembly (particularly bone reamers and similar tools used in joint implants) have crevices at the joints which are difficult and expensive to clean and fully sterilise. Welded instruments would eliminate this problem. Approximately 7000 cases of MRSA infections were reported in UK hospitals during 2007 and similar issues are prevalent across Europe. Such infections are of particular concern in post-surgery patients. The CleanTools project aims to develop technology which will reduce this issue by making surgical instruments easier to clean and disinfect. The crevice between stainless steel cutting heads and Shape Memory Alloy (SMA) flexible shafts currently makes decontamination challenging, time consuming and chemically intensive. Additionally there have been instances of cutting heads becoming detached from the flexible drive shaft during use, causing undue implications in theatre and potential long term impacts on patient quality of life. The desirable materials for these tools, such as SMAs and stainless steels, are challenging to weld and their properties are severely degraded when they are melted in conventional welding. CleanTools will provide a method for the manufacture of surgical instruments containing SMA materials though the use of rotary friction welding (RFW). RFW is a low heat input solid phase welding technology that will preserve the properties of the materials in question. CleanTools will improve the function of flexible surgical instruments, reduce the required cleaning and disinfection effort, improve reliability and reduce the cost of manufacture within Europe.


Grant
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 583.00K | Year: 2011

The objective of project BERTI (Biomedical implant with Exceptional Resistance to Tribo-bio-corrosion and with Inherent antimicrobial properties) is to develop an innovative joint replacement with a coating that minimises polyethylene and metal wear debris, prevents metal ion release and promotes the release of antimicrobial agents. The project will determine a method that establishes drivers for the detrimental responses to wear debris observed in patients. This information will be used to optimise a recently develop physical-vapour deposition coating that minimises wear and tribo-bio-corrosion while delivering an antimicrobial agent. In addition, the project will establish a test for patient susceptibility to ions release from implants. This will help identify patient cohorts who would benefit most from the novel coated implants, and will deliver to them, and to the wider population, a world-leading joint replacement with exceptional biocompatibility, longevity and antimicrobial properties. Project BERTI will ultimately increase the longevity of orthopaedic implants, reducing the number of revision surgeries, benefiting the UK and wider economy, and the patient.

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