Berkeley, CA, United States
Berkeley, CA, United States

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Krone R.,COR Innovations Inc. | Havenstrite K.,COR Innovations Inc. | Shafi B.,COR Innovations Inc.
Journal of the Mechanical Behavior of Biomedical Materials | Year: 2013

We present a method of characterizing the nonlinear stress-strain behavior of thin films of extremely soft, water-based polymer gels using uniaxial tension testing of bilayer laminates, in conjunction with methods of membrane nonlinear elasticity. A custom tensile testing apparatus is used to conduct quasi-static, uniaxial extension tests of narrow strips of thin, laminated sheets of bonded hydrogel and silicone rubber, submerged in a saline bath. The tensile load is measured via sensitive load cell and the position of material markers, at a central test-section of the sample, is optically tracked via digital image tracking methods. Stress-strain relationships are calculated for the hydrogel component of the bilayer, considered hyperelastic, homogeneous, isotropic, and incompressible, using membrane theories of finite hyperelasticity. We present the stress response for strains up to about 35% for poly(ethylene glycol) (PEG)-based hydrogels (>90 % water) with polymer concentrations by weight of 5% to 10%. Polynomial functions are fit to the data for each formulation, whereby the one-dimensional strain-energy function for each formulation is determined by taking the indefinite integral. © 2013 Elsevier Ltd.


PubMed | COR Innovations Inc.
Type: | Journal: Journal of the mechanical behavior of biomedical materials | Year: 2013

We present a method of characterizing the nonlinear stress-strain behavior of thin films of extremely soft, water-based polymer gels using uniaxial tension testing of bilayer laminates, in conjunction with methods of membrane nonlinear elasticity. A custom tensile testing apparatus is used to conduct quasi-static, uniaxial extension tests of narrow strips of thin, laminated sheets of bonded hydrogel and silicone rubber, submerged in a saline bath. The tensile load is measured via sensitive load cell and the position of material markers, at a central test-section of the sample, is optically tracked via digital image tracking methods. Stress-strain relationships are calculated for the hydrogel component of the bilayer, considered hyperelastic, homogeneous, isotropic, and incompressible, using membrane theories of finite hyperelasticity. We present the stress response for strains up to about 35% for poly(ethylene glycol) (PEG)-based hydrogels (>90% water) with polymer concentrations by weight of 5% to 10%. Polynomial functions are fit to the data for each formulation, whereby the one-dimensional strain-energy function for each formulation is determined by taking the indefinite integral.


Grant
Agency: National Science Foundation | Branch: | Program: SBIR | Phase: Phase I | Award Amount: 150.00K | Year: 2009

This Small Business Innovation Research (SBIR) Phase 1 project aims to develop a device to prevent congestive heart failure (CHF) in patients after a heart attack. There is currently no effective way to prevent the development of CHF. Several passive restraint devices placed around the heart have shown benefit in patients with established CHF. Recent animal studies have shown that these devices can prevent CHF when placed immediately after a heart attack. However, due to their permanence, they can only be used in patients with established CHF. This research continues the development and performs initial animal testing of a device to prevent progression to CHF in patients after a heart attack. The broader impact of this project will be to reduce CHF is, which is a disease that affects 5.5 million Americans costing the healthcare system $30 billion a year. Heart attacks, the leading cause of CHF, place the heart under significant mechanical stresses leading to CHF. Every year, almost 1.2 million patients suffer from a heart attack in the United States. Currently, there are only a few medical strategies to slow down progression to CHF and no real way to prevent it. This technology develops a minimally invasive biodegradable device to delay or prevent patients from developing CHF after a heart attack. This device will provide a much needed device based therapy, potentially radically modifying current treatment paradigms with an estimated annual market potential of $3 billion.

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