Copenhagen, Denmark
Copenhagen, Denmark

The University of Copenhagen is the oldest university and research institution in Denmark. Founded in 1479 as a studium generale, it is the second oldest institution for higher education in Scandinavia after Uppsala University . The university has 23,473 undergraduate students, 17,398 postgraduate students, 2,968 doctoral students and more than 9,000 employees. The university has four campuses located in and around Copenhagen, with the headquarters located in central Copenhagen. Most courses are taught in Danish; however, many courses are also offered in English and a few in German. The university has several thousands of foreign students, of whom about half come from Nordic countries.The university is a member of the prestigious International Alliance of Research Universities , along with University of Cambridge, University of Oxford, Yale University, The Australian National University, and UC Berkeley, amongst others. The Academic Ranking of World Universities, compiled by Shanghai Jiao Tong University, saw the University of Copenhagen as the leading university in Scandinavia and ranked 39th best university in the world in 2014. It is ranked 45th in the 2014 QS World University Rankings and 13th in Europe. Moreover, in 2013, according to the University Ranking by Academic Performance, the University of Copenhagen is the best university in Denmark and the 25th university in the world. The university has had 8 alumni become Nobel laureates and has produced one Turing Award recipient. Wikipedia.


Time filter

Source Type

Johansen J.V.,Copenhagen University
Nature Medicine | Year: 2017

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that is located in the pons and primarily affects children. Nearly 80% of DIPGs harbor mutations in histone H3 genes, wherein lysine 27 is substituted with methionine (H3K27M). H3K27M has been shown to inhibit polycomb repressive complex 2 (PRC2), a multiprotein complex responsible for the methylation of H3 at lysine 27 (H3K27me), by binding to its catalytic subunit EZH2. Although DIPGs with the H3K27M mutation show global loss of H3K27me3, several genes retain H3K27me3. Here we describe a mouse model of DIPG in which H3K27M potentiates tumorigenesis. Using this model and primary patient-derived DIPG cell lines, we show that H3K27M-expressing tumors require PRC2 for proliferation. Furthermore, we demonstrate that small-molecule EZH2 inhibitors abolish tumor cell growth through a mechanism that is dependent on the induction of the tumor-suppressor protein p16INK4A. Genome-wide enrichment analyses show that the genes that retain H3K27me3 in H3K27M cells are strong polycomb targets. Furthermore, we find a highly significant overlap between genes that retain H3K27me3 in the DIPG mouse model and in human primary DIPGs expressing H3K27M. Taken together, these results show that residual PRC2 activity is required for the proliferation of H3K27M-expressing DIPGs, and that inhibition of EZH2 is a potential therapeutic strategy for the treatment of these tumors. © 2017 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.


Patent
Copenhagen University | Date: 2015-03-04

The present disclosure relates to semiconductor based Josephson junctions and their applications within the field of quantum computing, in particular a tuneable Josephson junction device has been used to construct a gateable transmon qubit. One embodiment relates to a Josephson junction comprising an elongated hybrid nanostructure comprising superconductor and semiconductor materials and a weak link, wherein the weak link is formed by a semiconductor segment of the elongated hybrid nanostructure wherein the superconductor material has been removed to provide a semiconductor weak link.


Patent
Copenhagen University | Date: 2015-07-02

The present disclosure relates to nanoscale device comprising an elongated crystalline nanostructure, such as a nanowire crystal, a nanowhisker crystal or a nanorod crystal, and a method for producing thereof. One embodiment relates to a nanoscale device comprising an elongated crystalline semiconductor nanostructure, such as a nanowire (crystal) or nanowhisker (crystal) or nanorod (crystal), having a plurality of substantially plane side facets, a crystalline structured first facet layer of a superconductor material covering at least a part of one or more of said side facets, and a second facet layer of a superconductor material covering at least a part of the first facet layer, the superconductor material of the second facet layer being different from the superconductor material of the first facet layer, wherein the crystalline structure of the semiconductor nanostructure is epitaxially matched with the crystalline structure of the first facet layer on the interface between the two crystalline structures.


Patent
CelluComp, Novozymes AS and Copenhagen University | Date: 2017-03-29

Processes for producing cellulose microfibrils from herbaceous plant material using enzyme compositions, the cellulose microfibrils obtained from the processes and their uses, and compositions comprising the cellulose microfibrils are described.


Patent
Copenhagen University | Date: 2017-04-19

An optical device (1) comprising a planar waveguide (12) and a quantum emitter (18) is presented. The planar waveguide (2) comprises a longitudinal extending guiding region (4) with a first side (6) and a second side (8). A first nanostructure (7) is arranged on the first side (6) of the guiding region (4), and a second nanostructure (9) arranged on the second side (7) of the guiding region (4). The planar waveguide (2) includes a first longitudinal region (10) where the first nanostructure (7) and the second structure (9) are arranged substantially glide-plane symmetric about the guiding region (4) of the planar waveguide (2), and the quantum emitter (18) is coupled to the first longitudinal region (10) of the planar waveguide (18).


Patent
Copenhagen University | Date: 2017-03-29

An aqueous gel composition comprising a) water, at least one polysaccharide and at least one high molecular weight polyethylene oxide, wherein the water content is at least 90 % by weight of the composition, and b) a local anaesthetic agent or an analgesic agent, for use as a local anaesthetic or analgesic. The aqueous gel shows transparency, lubricity, stringiness, elongation, extensiveness, and cohesiveness while being devoid of taste and smell and non-tacky or non-sticky.


Patent
Copenhagen University | Date: 2017-05-10

The present disclosure relates to semiconductor based Josephson junctions and their applications within the field of quantum computing, in particular a tuneable Josephson junction device has been used to construct a gateable transmon qubit. One embodiment relates to a Josephson junction comprising an elongated hybrid nanostructure comprising superconductor (Al) and semiconductor (InAs) materials and a weak link, wherein the semiconductor weak link is formed by a semiconductor segment of the elongated hybrid nanostructure where the superconductor material has been removed.


Patent
Copenhagen University | Date: 2017-05-10

The present disclosure relates to nanoscale device comprising an elongated crystalline nanostructure, such as a nanowire crystal, a nanowhisker crystal or a nanorod crystal, and a method for producing thereof. One embodiment relates to a nanoscale device comprising an elongated crystalline semiconductor nanostructure, such as a nanowire (crystal) or nanowhisker (crystal) or nanorod (crystal), preferably made of Indium Arsenide, having a plurality of substantially plane side facets, a crystalline structured first facet layer of a superconductor material, preferably Aluminium, covering at least a part of one or more of said side facets, and a second facet layer of a superconductor material, preferably Vanadium, covering at least a part of the first facet layer, the superconductor material of the second facet layer being different from the superconductor material of the first facet layer, wherein the crystalline structure of the semiconductor nanostructure is epitaxially matched with the crystalline structure of the first facet layer on the interface between the two crystalline structures.


Borregaard N.,Copenhagen University
Immunity | Year: 2010

Neutrophils are produced in the bone marrow from stem cells that proliferate and differentiate to mature neutrophils fully equipped with an armory of granules. These contain proteins that enable the neutrophil to deliver lethal hits against microorganisms, but also to cause great tissue damage. Neutrophils circulate in the blood as dormant cells. At sites of infection, endothelial cells capture bypassing neutrophils and guide them through the endothelial cell lining whereby the neutrophils are activated and tuned for the subsequent interaction with microbes. Once in tissues, neutrophils kill microorganisms by microbicidal agents liberated from granules or generated by metabolic activation. As a final act, neutrophils can extrude stands of DNA with bactericidal proteins attached that act as extracellular traps for microorganisms. © 2010 Elsevier Inc.


Couchman J.R.,Copenhagen University
Annual Review of Cell and Developmental Biology | Year: 2010

Virtually allmetazoan cells contain at least one and usually several types of transmembrane proteoglycans. These are varied in protein structure and type of polysaccharide, but the total number of vertebrate genes encoding transmembrane proteoglycan core proteins is less than 10. Some core proteins, including those of the syndecans, always possess covalently coupled glycosaminoglycans; others do not. Syndecan has a long evolutionary history, as it is present in invertebrates, but many other transmembrane proteoglycans are vertebrate inventions. The variety of proteins and their glycosaminoglycan chains is matched by diverse functions. However, all assume roles as coreceptors, often working alongside high-affinity growth factor receptors or adhesion receptors such as integrins. Other common themes are an ability to signal through their cytoplasmic domains, often to the actin cytoskeleton, and linkage to PDZ protein networks. Many transmembrane proteoglycans associate on the cell surface with metzincin proteases and can be shed by them. Work with model systems in vivo and in vitro reveals roles in growth, adhesion, migration, and metabolism. Furthermore, a wide range of phenotypes for the core proteins has been obtained in mouse knockout experiments. Here some of the latest developments in the field are examined in hopes of stimulating further interest in this fascinating group of molecules. Copyright © 2010 by Annual Reviews. All rights reserved.

Loading Copenhagen University collaborators
Loading Copenhagen University collaborators