Coordination Chemistry Research Laboratory

Jabalpur, India

Coordination Chemistry Research Laboratory

Jabalpur, India
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Choubey A.,Sagar Institute of Science and Technology and Research | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Acharya C.,Sagar Institute of Science and Technology and Research
Asian Journal of Chemistry | Year: 2017

A novel bidentate ligand 1,6-bis(benzylidene)hexanediamine was synthesized and its eight ruthenium bis(bypyridine)sulphoxide complexes with the general formula [cis/trans-RuCl2 (SO)2 (N-N)](L); were SO = dimethyl sulphoxide (DMSO)/tetramethylene sulphoxide (TMSO), (N-N) = 1,10-phenanthroline/2,2'-bipyridyl, (L) = bridging ligand were synthesized. These complexes were characterized by elemental analysis, IR, UV/visible, 1H NMR, 13C NMR and 2D NMR spectroscopy. All complexes were found to show antibacterial property against E. coli and the pyridal ligands co-ordinate through a Ru-N bond in all cases.


Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Rai N.,Coordination Chemistry Research Laboratory | Mehrotra R.,Stellenbosch University
Journal of the Chinese Chemical Society | Year: 2014

Six complexes of Zn(II), Cd(II) and Hg(II) with sulphur containing Schiff base ligand, 1,4-bis((1H-pyrrol-2-yl)methylene)thiosemicarbazide in 1:1 and 1:2 ratio has been synthesized. Complexes were characterized by molar conductance measurement, elemental analyses, FT-IR, 1H-NMR, and FAB/ESI-Mass. The complexes were used as a single source precursor for the synthesis of ZnS/CdS/HgS nanoparticles by their thermal decomposition in the presence of different surfactants. The precursor: surfactant ratio and temperature plays important role in determining the size of the nanoparticles. The size and morphology of nanoparticles has been ascertained by UV-Vis spectroscopy, XRD measurements and Transmission Electron Microscopy (TEM). Schiff base, complexes and nanoparticles were tested for antibacterial activity and MIC values against E. coli. The complexes were found more potent than the corresponding Schiff bases and nanoparticles. Six complexes of 1,4-bis((1H-pyrrol-2-yl)methylene) thiosemicarbazide, Schiff base with Zn(II), Cd(II) and Hg(II) has been prepared. Using these complexes as precursor nanoparticles of ZnS, CdS and HgS have been prepared by thermal synthesis. Size and morphology of nanoparticles has been ascertained by X-ray and TEM analysis. Antibacterial activity and MIC of complexes and nanoparticles has been determined and compared with drug. © 2014 The Chemical Society Located in Taipei & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,Stellenbosch University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of the Serbian Chemical Society | Year: 2014

In this study, a dinucleating spacer incorporating two 2-aminopyridine units has been used to prepare seven novel dinuclear compounds. These molecules were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, FAB-Mass, electronic, 1H and 13C{1H}NMR spectral studies. The complex [{trans,mer-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 2 was also characterized through 1H-1H COSY NMR. There are mainly three different formulations; [{cis,fac-RuCl2(SO)3}2(μ-MBAP)].2SO; [{trans,mer-RuCl2(SO)3}2(μ-MBAP)].2SO and [{trans-RuCl4(SO)}2(μ-MBAP)]2- [X]2+; where SO = DMSO / TMSO; MBAP = 5,5'-methylenebis(2-aminopyridine) and [X]+ = [(DMSO)2H]+, Na+ or [(TMSO)H] +. The coordination was found through cyclic nitrogen of pyridine ring in octahedral environment for both metal centers. The chemical behivour of [{cis,fac-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 1 and 2 in aqueous solution with respect to time was observed by conductivity measurements and UV-vis spectrophotometer. All complexes were found to possess prominent antibacterial activity against Escherichia coli in comparison to Chloramphenicol and Gatifloxacin.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,Stellenbosch University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of the Serbian Chemical Society | Year: 2015

In this study, a dinucleating spacer incorporating two 2-aminopyridine units was used to prepare seven novel dinuclear compounds. These molecules were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, FAB-Mass, electronic, 1H-NMR and 13C{1H} - NMR spectral studies. The complex [{trans,mer-RuCl2(DMSO)3}2(μ-5,5′ - methylenebis(2-aminopyridine))]·2DMSO (2) was also characterized through 1H-1H COSY NMR. There are mainly three different formulations, [{cis,fac-RuCl2(SO)3}2(μ-MBAP)]·2SO; [{trans,mer-RuCl2(SO)3}2(μ-MBAP)]·2SO and [{trans-RuCl4(SO)}2(μ-MBAP)]2-[X]2+; where SO = DMSO / TMSO; MBAP = 5,5′-methylenebis(2-pyridinamine) and [X]+ = [(DMSO)2H]+, Na+ or [(TMSO)H]+. The coordination was found through cyclic nitrogen of the pyridine ring in an octahedral environment for both metal centres. The chemical behaviour of [{cis,fac-RuCl2(DMSO)3}2(μ-5,5′-methylenebis(2-pyridinamine))]·2DMSO (1) and (2) in aqueous solution with respect to time was observed by conductivity measurements and UV-Vis spectrophotometry. All complexes were found to possess prominent antibacterial activity against Escherichia coli in comparison to chloramphenicol and gatifloxacin. © 2015 SCS. All rights reserved.


Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Mehrotra R.,ITM University | Srivastava R.S.,University of Louisiana at Lafayette
E-Journal of Chemistry | Year: 2012

A bimetallic cuprous complex was accidentally reported, during synthesis of a dinucleating spacer incorporating two 2-chloropyridine units through S and mayer reaction. The product was characterized by elemental analysis, FAB-Mass, FT-IR, UV, magnetic susceptibility and 1H-NMR spectroscopic method. A possible mechanism is also proposed.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,ITM University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Dubey A.,Coordination Chemistry Research Laboratory
European Journal of Medicinal Chemistry | Year: 2012

Bacteria are amongst the most adaptable organisms on the Earth. The year 2010 was always remarkable for the article published in Lancet Infection Disease by Kumarasamy et al. and the enzyme NDM-1 which makes bacteria resist designed to kill them. Four rhodium(III) chloride complexes with Gatifloxacin have been prepared and characterized by elemental analyses, molar conductance measurements, FTIR, FAB-MS, TGA, 1H NMR and electronic spectral studies. The general formula for complexes are [X] + fac-[RhCl 3(L)(GT)] -; where L = H 2O, Dimethylsulfoxide (DMSO), Tetramethylenesulfoxide (TMSO); GT = Gatifloxacin and X = Na or [H(DMSO) 2]. All complexes are found to possess prominent antibacterial activity against pathogenic Escherichia coli and Mycobacterium tuberculosis in comparison to Gatifloxacin. © 2012 Elsevier Masson SAS. All rights reserved.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,ITM University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Medicinal Chemistry Research | Year: 2012

Abstract: It has been observed that antibiotic susceptibility against several bacterial strains varies with time and environment. The widespread drug resistance against pathogens in our environment stresses the need for regular monitoring of antibiotics' susceptibility, and developing a new design being active against resist pathogens. In this study, a Schiff base derivative of Ofloxacin has been synthesized and characterized by FT-IR, 1H-NMR, 13C{ 1H}NMR, and 1H- 1H COSY analyses. Ruthenium(II/III) complexes of this ligand have been prepared, and characterized by elemental analyses, molar conductance measurements, magnetic susceptibility, FT-IR, FAB-Mass, NMR, and electronic spectral studies. There are two different formulations: [Na] +[cis, cis-RuCl 2(DMSO-S) 2 (OFAD)] -, and [X] +[mer-RuCl 3(DMSO-S)(OFAD)] - where OFAD = (7E)-9-fluoro-3-methyl-10-(4-methyl-piperazin-1-yl)-7-(phenylimino)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; and DMSO = dimethylsulfoxide and [X] +=[H(DMSO) 2] + or Na +. All the complexes are found to possess plasma proteins interaction in blood and exhibit prominent antibacterial activity against pathogenic Escherichia coli in comparison to Ofloxacin and Ciprofloxacin. Graphical abstract: Increasing multidrug-resist pathogens have become serious problem, therefore monitoring of antibiotics susceptibility and to develop new design remains challenge. An Ofloxacin Schiff base derivative has been synthesized and explore with ruthenium sulfoxide precursor with anticipating better activity. Metalloantibiotics are promising for amendment of drug against resist pathogens.[Figure not available: see fulltext.] © 2012 Springer Science+Business Media, LLC.


Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Dubey A.,Coordination Chemistry Research Laboratory | Mathews S.,Coordination Chemistry Research Laboratory | And 2 more authors.
Journal of Coordination Chemistry | Year: 2012

A dinucleating spacer 1,4-bis(salicylidene)phenylenediamine (SALPHEN) derived from 1,4-phenylenediamine and salicylaldehyde has been synthesized and characterized. The ruthenium(II) sulfoxide derivative of 2,2′-bipyridine or 1,10-phenanthroline on reaction with this ligand resulted in the formation of eight dinuclear complexes, which were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, fast atom bombardment-mass spectra, electronic spectroscopy, 1H-NMR, 13C{ 1H}-NMR, and 2D-NMR spectra (HETCOR). The prepared complexes have two different formulations, [{trans-RuCl 2(so)(N-N′)} 2(μ-SALPHEN)] and [{cis-RuCl 2(so)(N-N′)} 2(μ-SALPHEN)], where so=dimethyl sulfoxide (DMSO)/tetramethylene sulfoxide (TMSO), N-N′ =2,2′-bipyridine/ 1,10-phenanthroline, and SALPHEN=1,4-bis(salicylidene) phenylenediamine. Two moles of ruthenium sulfoxide bipyridine precursor were coordinated to the bidentate SALPHEN through nitrogen. All the complexes possess antibacterial activity against Escherichia coli in comparison to Chloramphenicol. © 2012 Taylor & Francis.


Mehrotra R.,ITM University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of Coordination Chemistry | Year: 2012

A new bis-N,N′-bidentate Schiff base has been synthesized, characterized, and used in the synthesis of Ru II and Rh II complexes, which were further applied as precursors in the preparation of trinuclear complexes. These complexes were characterized by elemental analyses, molar conductance measurements, magnetic susceptibility, FTIR, TGA, FAB-mass, ESI-MS, 1H-NMR, 13C{ 1H}-NMR, 1H- 1H COSY 2D-NMR, and electronic spectral studies. In complexes, one metal center is coordinated through azomethine nitrogen of bis-N,N′- bidentate Schiff base and the other two metal ions are coordinated through nitrogen of pyridine. © 2012 Copyright Taylor and Francis Group, LLC.


Mehrotra R.,Coordination Chemistry Research Laboratory | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of Coordination Chemistry | Year: 2015

Drug resistance in pathogens is a growing global health problem. The development of new drugs is a risky, time-consuming, and expensive process, since only a few got final approval. Organometallic compounds attracted attention due to their promising anticancer activities. In this study, four cyclometallates containing ruthenium and rhodium ions were synthesized from two phenolic azo ligands. These molecules were characterized by elemental analyses, molar conductance measurements, magnetic susceptibility, FT-IR, mass, electronic, 1H, 13C{1H}, and 31P{1H} NMR spectral studies. The general formula for the complexes is trans-[M(PPh3)2(Cl)(L)], where M = Rh or Ru, PPh3 = triphenylphosphine, and L = phenolic azo ligand. All the complexes possess prominent antibacterial activity against Escherichia coli and Mycobacterium tuberculosis as compared to market drugs. The interactions of rhodium derivatives with plasma-protein were also studied. © 2015 Taylor & Francis.

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