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Mehrotra R.,ITM University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of Coordination Chemistry | Year: 2012

A new bis-N,N′-bidentate Schiff base has been synthesized, characterized, and used in the synthesis of Ru II and Rh II complexes, which were further applied as precursors in the preparation of trinuclear complexes. These complexes were characterized by elemental analyses, molar conductance measurements, magnetic susceptibility, FTIR, TGA, FAB-mass, ESI-MS, 1H-NMR, 13C{ 1H}-NMR, 1H- 1H COSY 2D-NMR, and electronic spectral studies. In complexes, one metal center is coordinated through azomethine nitrogen of bis-N,N′- bidentate Schiff base and the other two metal ions are coordinated through nitrogen of pyridine. © 2012 Copyright Taylor and Francis Group, LLC.


Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Mehrotra R.,ITM University | Srivastava R.S.,University of Louisiana at Lafayette
E-Journal of Chemistry | Year: 2012

A bimetallic cuprous complex was accidentally reported, during synthesis of a dinucleating spacer incorporating two 2-chloropyridine units through S and mayer reaction. The product was characterized by elemental analysis, FAB-Mass, FT-IR, UV, magnetic susceptibility and 1H-NMR spectroscopic method. A possible mechanism is also proposed.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,ITM University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Dubey A.,Coordination Chemistry Research Laboratory
European Journal of Medicinal Chemistry | Year: 2012

Bacteria are amongst the most adaptable organisms on the Earth. The year 2010 was always remarkable for the article published in Lancet Infection Disease by Kumarasamy et al. and the enzyme NDM-1 which makes bacteria resist designed to kill them. Four rhodium(III) chloride complexes with Gatifloxacin have been prepared and characterized by elemental analyses, molar conductance measurements, FTIR, FAB-MS, TGA, 1H NMR and electronic spectral studies. The general formula for complexes are [X] + fac-[RhCl 3(L)(GT)] -; where L = H 2O, Dimethylsulfoxide (DMSO), Tetramethylenesulfoxide (TMSO); GT = Gatifloxacin and X = Na or [H(DMSO) 2]. All complexes are found to possess prominent antibacterial activity against pathogenic Escherichia coli and Mycobacterium tuberculosis in comparison to Gatifloxacin. © 2012 Elsevier Masson SAS. All rights reserved.


Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory | Dubey A.,Coordination Chemistry Research Laboratory | Mathews S.,Coordination Chemistry Research Laboratory | And 2 more authors.
Journal of Coordination Chemistry | Year: 2012

A dinucleating spacer 1,4-bis(salicylidene)phenylenediamine (SALPHEN) derived from 1,4-phenylenediamine and salicylaldehyde has been synthesized and characterized. The ruthenium(II) sulfoxide derivative of 2,2′-bipyridine or 1,10-phenanthroline on reaction with this ligand resulted in the formation of eight dinuclear complexes, which were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, fast atom bombardment-mass spectra, electronic spectroscopy, 1H-NMR, 13C{ 1H}-NMR, and 2D-NMR spectra (HETCOR). The prepared complexes have two different formulations, [{trans-RuCl 2(so)(N-N′)} 2(μ-SALPHEN)] and [{cis-RuCl 2(so)(N-N′)} 2(μ-SALPHEN)], where so=dimethyl sulfoxide (DMSO)/tetramethylene sulfoxide (TMSO), N-N′ =2,2′-bipyridine/ 1,10-phenanthroline, and SALPHEN=1,4-bis(salicylidene) phenylenediamine. Two moles of ruthenium sulfoxide bipyridine precursor were coordinated to the bidentate SALPHEN through nitrogen. All the complexes possess antibacterial activity against Escherichia coli in comparison to Chloramphenicol. © 2012 Taylor & Francis.


Mehrotra R.,Coordination Chemistry Research Laboratory | Mehrotra R.,Stellenbosch University | Shukla S.N.,Coordination Chemistry Research Laboratory | Gaur P.,Coordination Chemistry Research Laboratory
Journal of the Serbian Chemical Society | Year: 2014

In this study, a dinucleating spacer incorporating two 2-aminopyridine units has been used to prepare seven novel dinuclear compounds. These molecules were characterized by elemental analyses, conductivity measurements, magnetic susceptibility, FT-IR, FAB-Mass, electronic, 1H and 13C{1H}NMR spectral studies. The complex [{trans,mer-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 2 was also characterized through 1H-1H COSY NMR. There are mainly three different formulations; [{cis,fac-RuCl2(SO)3}2(μ-MBAP)].2SO; [{trans,mer-RuCl2(SO)3}2(μ-MBAP)].2SO and [{trans-RuCl4(SO)}2(μ-MBAP)]2- [X]2+; where SO = DMSO / TMSO; MBAP = 5,5'-methylenebis(2-aminopyridine) and [X]+ = [(DMSO)2H]+, Na+ or [(TMSO)H] +. The coordination was found through cyclic nitrogen of pyridine ring in octahedral environment for both metal centers. The chemical behivour of [{cis,fac-RuCl2(DMSO)3}2(μ-5,5'-methylenebis(2-aminopyridine))].2DMSO, 1 and 2 in aqueous solution with respect to time was observed by conductivity measurements and UV-vis spectrophotometer. All complexes were found to possess prominent antibacterial activity against Escherichia coli in comparison to Chloramphenicol and Gatifloxacin.

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