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Palma I.,National Polytechnic Institute of Mexico | Sanchez A.E.,National Polytechnic Institute of Mexico | Sanchez A.E.,Laboratorio Of Virologia | Jimenez-Hernandez E.,Hospital Pediatrico Moctezuma Secretaria de Salud | And 14 more authors.
Clinical Lymphoma, Myeloma and Leukemia | Year: 2013

Background: Epstein-Barr virus (EBV) is a member of the Herpesviridae family and is associated with Hodgkin lymphoma (HL). Isolates of EBV are classified according to sequence variation in the latency genes such as Epstein-Barr virus nuclear antigen (EBNA). EBNA2 contains the most divergent locus and is classified into type 1 and type 2 or EBNA2A and EBNA2B, respectively. We compared the frequency of EBV and the distribution of EBNA genotypes in Mexican children and adults with HL. Patients and Methods: Lymph node biopsy specimens from children and adults with HL were embedded in paraffin. EBV was identified by LMP1 amplification and Epstein-Barr-encoded RNA EBER by in situ hybridization (ISH) and genotyped as EBNA2A or EBNA2B using nested polymerase chain reaction (PCR) and specific primers for the detection of subtype. Results: Sixty-six samples were obtained from 3 hospitals - 42 (63%) from children and 24 (37%) from adults with HL. Thirty-two of the 42 samples (76.1%) were positive for EBV in children and 16 of 24 (66.6%) samples were positive in adults (P =.41). In both children and adults, EBV was found more frequently in male patients. Thirty-four of 48 cases could be typed (70.8%). EBNA2A was found in 7/21 (33.3%) children and in 4/13 (30.8%) adults (P = 1.0), and EBNA2B was found in 10/21 (47.6%) children and in 9/13 (69.2%) adults (P =.22). A mix of subtypes was found in 4/21 (19%) children. Conclusion: EBV was found frequently in both children and adults with HL. EBNA2B was the most frequent subtype, and a high frequency of mixed subtypes was found in children.

Salcedo M.,Instituto Mexicano del Seguro Social Mexican Institute for Social Security | Pina-Sanchez P.,Instituto Mexicano del Seguro Social Mexican Institute for Social Security | Vallejo-Ruiz V.,Research Center Biomedica Of Oriente Imss | Monroy-Garcia A.,Instituto Mexicano del Seguro Social Mexican Institute for Social Security | And 39 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at the Mexican Institute for Social Security from different areas of Mexico. Materials and Methods: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC. Results: Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association. Conclusions: The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.

Introduction: In Mexico, ischemic heart disease is a major cause of death and representing 18[%] of all deaths per year, approximately 45[%] of these patients have arterial hypertension and 20[%] have less control of their figures tension. The CASP measurement by analysis of the pulse wave is associated with more adverse than the single blood pressure measurement events. At present there are no studies on the subject, in patients diagnosed with ACS. Objective: To evaluate the prognosis of measuring the Central Aortic Systolic Pressure by radial CASP as a risk factor in hypertensive patients with ACS. Material and methods: This is a cohort study in patients admitted to the Inpatient Units, diagnosed with ACS according to international criteria (ACC/AHA/ESC) who underwent measurement of CASP by analyzing pulse wave and Augmentation Index (RAI) using BPro device in patients with and without arterial hypertension. CASP and RAI was measured using a scale expected by age and gender two groups according to the normality of the CASP, cardiovascular events (death, re-infarction, cerebrovascular events, functional class and need new hospitalizations were identified) were evaluated during hospitalization and one month follow-up. Results: We included 150 patients in the study, 105 hypertensive patients (group A) and 45 non-hypertensive patients (group B) and 50 controls (group C). The average age of the patients was 62.6 years, 78[%] male gender, other risk factors were distributed as follows: 52[%] smoking, diabetes, dyslipidemia 39.8 and 42[%]. The mean baseline heart rate was 73 bpm. A statistically significant difference in the numbers of diastolic blood pressure (73 with 78 mmHg, p = 0.014) was found. The average value of the CASP for each group was 102.5 ± 10.1 mmHg in controls, 107.8 ± 16.1 mmHg in normotensive and 118 ± 14.7 mmHg in hypertensive, with a significant difference (p < 0.0001). 53[%] of hypertensive patients had an abnormal CASP with respect to age and gender compared to normotensive subjects (35[%]) and healthy controls (22[%]). The incidence of MACE at 7 and 30 days was higher in the hypertensive group (p < 0.0001). Patients with abnormal CASP regardless of whether or not hypertension had a higher rate of adverse events during hospitalization (RR 2.7, 95[%] CI 1.38-5.45, p = 0.003) and at 30 days follow-up (RR 2.11, 95[%] CI 1.1-4.2, p = 0.018). Conclusions: The arterial hypertension is a risk factor for developing a CASP outside the normal range for age and gender compared with non-hypertensive patients and healthy controls. Our findings demonstrate for the first time in Mexico that measuring central aortic systolic pressure calculated by the radial CASP can be used as an independent predictor of major cardiovascular events 7 and 30 days in patients with ACS, which we consider to be assessed in these patients.

Lopez-Alvarenga J.C.,Direccion de Investigacion | Lopez-Alvarenga J.C.,Takeda Mexico S.A. de C.V. | Orr W.,The Lynn Health Science Institute | Vargas-Romero J.A.,Takeda Mexico S.A. de C.V. | And 15 more authors.
Journal of Neurogastroenterology and Motility | Year: 2014

Background/Aims: To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. Methods: Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient- completed ReQuest in ™ questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms. Results: Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in Practice™ dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated. Conclusions: Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present.© 2014 The Korean Society of Neurogastroenterology and Motility.

Dircio Montes Sergio A.,Instituto Mexicano del Seguro Social IMSS | Gonzalez Figueroa E.,Instituto Mexicano del Seguro Social IMSS | Maria Saadia V.G.,Coordinacion de Salud Publica | Elizabeth S.H.,Coordinacion de Investigacion en Salud | And 3 more authors.
Journal of Tropical Medicine | Year: 2012

Objective. To determine the prevalence of leptospirosis in patients from Veracruz with initial diagnosis of dengue and its association with risk factors. Materials and Methods. Transversal study in patients who sought medical attention under the suspicion of dengue. Backgrounds were researched and blood samples were drawn to determine dengue (NS1, RT-PCR) and leptospirosis (IFI). Simple frequencies, central tendency and dispersion measures, and prevalence and trust intervals at 95 (IC95) were obtained. Prevalence reasons (RP) and IC95 were obtained and a multivariate logistic model was applied, using SPSSV15. Results. 171 patients were included, 56 women (32±14 years) and 44 men (32±17 years). 48 of the cases (IC9540.5-55.4) was positive to dengue, with a cut point of 1:80, seroprevalence for leptospirosis was of 6 (IC952.7-10); 12 (IC957-16.5) was positive to both pathologies and 34 was negative to both tests. Although the largest number of isolations corresponded to serotype 2, the four dengue virus serotypes were identified. In the bivariate analysis, overcrowding RP=1.33, (IC=0.46-3.5), bathing in rivers (RP=1.31, IC=0.13-7.4), and walking barefoot (RP=1.39, IC=0.58-3.3) were the variables associated with leptospirosis, although the relation was not statistically significant. Conclusions. Leptospirosis prevalence in subjects under suspicion of dengue fever is high, as well as the coincidence of both infections. The results show the coexistence of overlapped outbreaks of several diseases sharing the side of transmission. It is necessary the intentional search of other pathologies, such as influenza, rickettsiosis, and brucella, among others. © 2012 A. Dircio Montes Sergio et al.

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