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News Article | November 24, 2016
Site: www.newsmaker.com.au

MarketStudyReport.com adds “Global Viscosupplementation Market 2016-2020” new report to its research database. The report spread across 80 pages with table and figures in it. The research analysts forecast the global Viscosupplementation market to grow at a CAGR of 6.23% during the period 2016-2020. About Viscosupplementation Viscosupplementation is a minimally invasive treatment for knee osteoarthritis. It involves the injection of hyaluronic acid into a knee joint to assist the viscous properties of synovial fluid. The procedure increases the joint?s functioning and reduces pain. Intra-articular viscosupplementation with hyaluronic acid is gaining acceptance as it is a non-invasive procedure compared to knee replacement. It is categorized into three product segments ?- single-injection cycle, three-injection cycle, and five-injection cycle. Covered in this report The report covers the present scenario and the growth prospects of the global Viscosupplementation market for 2016-2020. To calculate the market size, the report considers the revenue generated from the sale of products in different regions. The market is divided into the following segments based on geography: - Americas - APAC - EMEA Research report, Global Viscosupplementation Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market. Browse full table of contents and data tables at https://www.marketstudyreport.com/reports/global-viscosupplementation-market-2016-2020/ Key vendors - Sanofi - Anika Therapeutics - Seikagaku - Fidia Farmaceutici - Ferring Pharmaceuticals Other prominent vendors - Allergan - Contipro Biotech - DePuy Synthes - F. Hoffmann-La Roche - Galderma - HTL Biotechnology - Hyaltech - Expanscience Laboratoires - Lifecore Biomedical - Lipo Chemicals - Merz Aesthetics - Mylan - Nordic Drugs - Shandong Freda Biochem - Shanghai Jingfeng Pharmaceutical - Smith & Nephew - TEIJIN PHARMA - TRB Chemedica International Market driver - Fast-growing geriatric population - For a full, detailed list, view our report Market challenge - Threat from substitutes - For a full, detailed list, view our report Market trend - Increasing patient preference for single-injection cycle - For a full, detailed list, view our report Key questions answered in this report - What will the market size be in 2020 and what will the growth rate be? - What are the key market trends? - What is driving this market? - What are the challenges to market growth? - Who are the key vendors in this market space? - What are the market opportunities and threats faced by the key vendors? - What are the strengths and weaknesses of the key vendors? To receive personalized assistance, write to us @ [email protected] with the report title in the subject line along with your questions or call us at +1 866-764-2150


Mrazek J.,Charles University | Pospisilova M.,Contipro Biotech | Svozil V.,Contipro Biotech | Cadek O.,Contipro Biotech | And 5 more authors.
Journal of Biomedical Optics | Year: 2016

We describe a modification of epifluorescence microscopes that allows quantitative widefield imaging of samples labeled by upconverting nanoparticles (UCNP). A top-hat illumination profile on the sample was achieved with a 980-nm laser diode by using tandem microlens arrays, a moving diffuser and a telescope, which adjusts the top-hat area to the field of view. Illumination homogeneity is a critical factor for imaging of UCNP since the intensity of their luminescence typically scales with the second power of the excitation intensity. Our illuminator is combined with the epifluorescence attachment of the microscope, allowing easy switching between observation of UCNP and traditional fluorescent dyes. Illumination profile homogeneity of about 98% was measured for objectives with magnification from 4× to 100×, and the top-hat profile was also obtained with phase contrast objectives. We demonstrate capability of the illuminator by evaluating in vitro uptake of UCNP encapsulated in oleyl-hyaluronan micelles into breast cancer cells. Micelles bearing the targeting peptide were about an order of magnitude more efficient than nontargeted micelles. © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).


Pospisilova M.,Contipro Biotech | Mrazek J.,Contipro Biotech | Mrazek J.,Charles University | Matuska V.,Contipro Biotech | And 7 more authors.
Journal of Nanoparticle Research | Year: 2015

Hyaluronan (HA) represents an interesting polymer for nanoparticle coating due to its biocompatibility and enhanced cell interaction via CD44 receptor. Here, we describe incorporation of oleate-capped β–NaYF4:Yb3+, Er3+ nanoparticles (UCNP-OA) into amphiphilic HA by microemulsion method. Resulting structures have a spherical, micelle-like appearance with a hydrodynamic diameter of 180 nm. UCNP-OA-loaded HA micelles show a good stability in PBS buffer and cell culture media. The intensity of green emission of UCNP-OA-loaded HA micelles in water is about five times higher than that of ligand-free UCNP, indicating that amphiphilic HA effectively protects UCNP luminescence from quenching by water molecules. We found that UCNP-OA-loaded HA micelles in concentrations up to 50 μg mL−1 increase cell viability of normal human dermal fibroblasts (NHDF), while viability of human breast adenocarcinoma cells MDA–MB–231 is reduced at these concentrations. The utility of UCNP-OA-loaded HA micelles as a bio-imaging probe was demonstrated in vitro by successful labelling of NHDF and MDA–MB–231 cells overexpressing the CD44 receptor. © 2015, Springer Science+Business Media Dordrecht.


Huerta-Angeles G.,Contipro Biotech | Nemcova M.,Contipro Biotech | Prikopova E.,Contipro Biotech | Smejkalova D.,Contipro Biotech | And 3 more authors.
Carbohydrate Polymers | Year: 2012

Hyaluronan (HA) based hydrogels have been synthesized combining chemical modification of the polysaccharide by partial oxidation, reductive amination and 'click chemistry'. HA was oxidized by 4-acetamido-TEMPO-mediated reaction, using sodium hypochlorite as primary oxidant and NaBr in buffered pH, so that the produced aldehyde moieties (hemiacetals) were trapped in situ by adding primary amines containing azide or alkyne-terminal groups. The structure of the reaction products, oxidized-HA and primary amines bonded to HA, was elucidated using 2D NMR spectroscopy. SEC-MALLS analysis of the modified substrates showed a negligible degradation of the polysaccharide using this procedure. Furthermore, azido- and alkynyl derivatives underwent cross-linking by click chemistry into hydrogels, which were characterized by NMR, FT-IR, swelling degree and mechanical properties. Possible application of the material as scaffold for tissue engineering was tested by seeding and proliferation of chondrocytes for up to 15 days. © 2012 Elsevier Ltd. All rights reserved.


PubMed | Contipro Biotech
Type: Journal Article | Journal: Carbohydrate polymers | Year: 2012

Hyaluronan (HA) based hydrogels have been synthesized combining chemical modification of the polysaccharide by partial oxidation, reductive amination and click chemistry. HA was oxidized by 4-acetamido-TEMPO-mediated reaction, using sodium hypochlorite as primary oxidant and NaBr in buffered pH, so that the produced aldehyde moieties (hemiacetals) were trapped in situ by adding primary amines containing azide or alkyne-terminal groups. The structure of the reaction products, oxidized-HA and primary amines bonded to HA, was elucidated using 2D NMR spectroscopy. SEC-MALLS analysis of the modified substrates showed a negligible degradation of the polysaccharide using this procedure. Furthermore, azido- and alkynyl derivatives underwent cross-linking by click chemistry into hydrogels, which were characterized by NMR, FT-IR, swelling degree and mechanical properties. Possible application of the material as scaffold for tissue engineering was tested by seeding and proliferation of chondrocytes for up to 15 days.

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