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Murthy T.V.,Thermo Fisher Scientific | Kroncke D.,Continuum Inc. | Bonin P.D.,Pfizer
Journal of Laboratory Automation | Year: 2011

Miniaturizing experimental sample volumes to the nanoliter volume range is one of the most economical ways to perform mid- and high-throughput compound screening experiments. Existing automation platforms for nanoliter fluid handling can be bulky, expensive, and require periodic calibration to provide consistent liquid dispensing. In addition, even with frequent calibration, significant instrument-to-instrument variation in low-volume dispensing can occur between different instrument platforms. Many of these issues can be addressed by the use of PocketTips. PocketTips are tips with a defined internal pocket designed to hold specific nanoliter volumes of compound dissolved in dimethylsulfoxide. Although the overall liquid-handling process with PocketTips uses the aspirate/dispense features of the specific liquid-handling device being used, the dispensed nanoliter volume is solely based on the dimensions of the pocket of the PocketTip and thus, the liquid-handling device itself need not have nanoliter dispensing capabilities. In this report, we demonstrate the performance of PocketTips on different automation platforms. In addition, we used a cell-based ß-lactamase reporter assay system to demonstrate that compound delivery by PocketTips compares favorably with a standard compound addition technique. © 2011 Society for Laboratory Automation and Screening.


Zhang Y.,Ohio State University | Babu S.S.,Ohio State University | Prothe C.,Dynamic Materials Corporation | Blakely M.,Dynamic Materials Corporation | And 3 more authors.
Journal of Materials Processing Technology | Year: 2011

Three complementary impact welding technologies are described in this paper. They are explosive welding, magnetic pulse welding, and laser impact welding, which have been used to provide metallurgical bonds between both similar and dissimilar metal pairs. They share the physical principle that general impact-driven welding can be carried out by oblique impact but are used at different length scales from meters to sub-millimeter. The different length scales require different kinds of systems to drive the process, and the scales themselves can give different weld morphologies. Metallographic analysis on cross-sections shows a wavy interface morphology which is likely the result of an instability associated with jetting, which scours the surfaces clean during impact. The normalized period and amplitude of the undulations increase with increasing impact energy density. Microhardness testing results show the impact welded interface has a much greater hardness than the base metals. This can lead to weldments that have strengths equal to or greater than that of the weakest base material. © 2010 Elsevier B.V. All rights reserved.


Pagotto J.,Center for Security Science | O'Donnell D.,Continuum Inc.
ISCRAM 2012 Conference Proceedings - 9th International Conference on Information Systems for Crisis Response and Management | Year: 2012

The Canadian Multi-Agency Situational Awareness System (MASAS) is rapidly becoming Canada's national system for exchanging emergency management incident-relevant information amongst multiple agencies and jurisdictions. Through the use of structured information aligned with open standards, and a centrally managed open architecture, MASAS provides a trusted virtual community with the ability to seamlessly exchange emergency management information. MASAS offers an information exchange architecture that is based around a highly resilient system of data aggregation hubs that are easily accessible directly or through third party commercial tools by emergency management officials at all levels, from the smallest community in the most remote areas of Canada's north to key federal stakeholders such as the federal Government Operations Centre or the Canadian military. This paper highlights the key design principles, experimental activities, and technology implementation strategies that are positioning MASAS as a Canadian success story in the making - from coast to coast to coast. © 2012 ISCRAM.


Chang C.,Continuum Inc. | Cramer L.,Continuum Inc. | Danielson D.,Continuum Inc. | Norby J.,Continuum Inc.
Proceedings of SPIE - The International Society for Optical Engineering | Year: 2015

Many beams that output from standard commercial lasers are multi-mode, with each mode having a different shape and width. They show an overall non-homogeneous energy distribution across the spot size. There may be satellite structures, halos and other deviations from beam uniformity. However, many scientific, industrial and medical applications require flat top spatial energy distribution, high uniformity in the plateau region, and complete absence of hot spots. Reliable standard methods for the evaluation of beam quality are of great importance. Standard methods are required for correct characterization of the laser for its intended application and for tight quality control in laser manufacturing. The International Organization for Standardization (ISO) has published standard procedures and definitions for this purpose. These procedures have not been widely adopted by commercial laser manufacturers. This is due to the fact that they are unreliable because an unrepresentative single-pixel value can seriously distort the result. We hereby propose a metric of beam uniformity, a way of beam profile visualization, procedures to automatically detect hot spots and beam structures, and application examples in our high energy laser production. © 2015 SPIE CCC.


Patent
Continuum Inc. | Date: 2013-01-03

A method includes receiving from a requestor search criteria for a geospatial information service. The requestor selects a dataset for use in providing the geospatial information service. A plurality of processes is determined, resulting in process-dataset solutions to the search criteria including the selected dataset. In particular, each process-dataset solution includes the selected dataset and a process of the determined plurality of processes. A list is provided to the requestor, the list including the plurality of process-dataset solutions.


Patent
Continuum Inc. | Date: 2016-09-13

A method includes receiving from a requestor search criteria for a geospatial information service. The requestor selects a dataset for use in providing the geospatial information service. A plurality of processes is determined, resulting in process-dataset solutions to the search criteria including the selected dataset. In particular, each process-dataset solution includes the selected dataset and a process of the determined plurality of processes. A list is provided to the requestor, the list including the plurality of process-dataset solutions.


PubMed | Continuum Inc.
Type: Journal Article | Journal: Integrative medicine (Encinitas, Calif.) | Year: 2016

The continuum cleft is a costly and precarious gap that divides professions on the health professions continuum. It is an interprofessional phenomenon that is encouraged because health care professions protect their members in professional silos and isolate competing professions in professional cysts. This article uses case studies of the allopathic, osteopathic, naturopathic, and chiropractic professions to contemplate the existence, consequences, and possible mitigation of intraprofessional silos, cysts, and clefts.


A method for determining a value indicator in a broker-mediated geospatial information service environment includes receiving feedback data at a first system of the broker-mediated geospatial information service environment. In particular, the feedback data is received from a plurality of respondents, and relates to a broker-mediated geospatial information service provided to each respondent of the plurality of respondents. Furthermore, each respondent of the plurality of respondents is a prior requestor of a process-dataset solution for performing the broker-mediated geospatial information service. Based on the feedback data, a value indicator relating to the process-dataset solution is determined.


A method for determining a value indicator in a broker-mediated geospatial information service environment includes receiving feedback data at a first system of the broker-mediated geospatial information service environment. In particular, the feedback data is received from a plurality of respondents, and relates to a broker-mediated geospatial information service provided to each respondent of the plurality of respondents. Furthermore, each respondent of the plurality of respondents is a prior requestor of a process-dataset solution for performing the broker-mediated geospatial information service. Based on the feedback data, a value indicator relating to the process-dataset solution is determined.


Trademark
Continuum Inc. | Date: 2016-04-12

Lasers; high energy nanosecond lasers.

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