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Sirotkin A.V.,Constantine the Philosopher University
European Journal of Pharmacology

The chemical structure, classification, source, metabolism, physiological and health effects of plant phytoestrogens and mechanisms of their action are reviewed. The available knowledge suggests that phytoestrogens can affect a number of physiological and pathological processes related to reproduction, bone remodeling, skin, cardiovascular, nervous, immune systems and metabolism. Due to these effects, phytoestrogens and phytoestrogen-containing diet can be useful for the prevention and treatment of menopausal symptoms, skin aging, osteoporosis, cancer, cardiovascular, neurodegenerative, immune and metabolic diseases. Possible problems in understanding and application of phytoestrogens (multiple targets and multiple estrogen receptor -dependent and -independent mechanisms of action, the discrepancy between the results of experimental and clinical studies, adequate source of phytoestrogen) have been discussed. © 2014 Elsevier B.V. All rights reserved. Source

Jomova K.,Constantine the Philosopher University | Valko M.,Slovak University of Technology in Bratislava
European Journal of Medicinal Chemistry

Carotenoids are natural pigments attracting attention of physicists, chemists and biologists due to their multiple functions in the nature. While carotenoids have unusually high extinction coefficients, they do not exhibit adequate emission. This fact has resulted in detailed studies of photophysical and photochemical properties of carotenoids and their role as light-harvesting pigments in photosynthesis. Carotenoids are abundantly present in fruits and vegetables and are considered as important species with beneficial effect on human health by decreasing the risk of various diseases, particularly decreasing the incidence of cancers and eye disease. More trials are needed to ascertain the role of carotenoids in prevention of cardiovascular disease and metabolic disease. Carotenoids effectively scavenge peroxyl radicals and act predominantly as antioxidants. However, under conditions of increased concentration of oxygen and carotenoid concentration, beta-carotene was found to exhibit prooxidant behaviour. Photophysical properties of carotenoids and conditions affecting a switch between antioxidant and prooxidant behaviour of carotenoids are the main aims of this review. In addition, the localization of carotenoids in biological membranes, their interactions and reactions with ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) as well as their redox potentials are discussed in view of their antioxidant properties as beneficial species in preventing various diseases. © 2013 Elsevier Masson SAS. All rights reserved. Source

Antosova M.,Constantine the Philosopher University
European Journal of Science and Theology

This paper deals with philosophical inspirations of the Slovak writer D. Tatarka who is perceived as a philosophizing writer in the literary world. In addition to peripheral interconnections of the author with different philosophers (E. Levinas, J. Patočka, etc.) he is most often and very frequently correlated by professionals with the French philosophy of existentialism (J.P. Sartre, G. Marcel, A. Camus). Our paper is precisely focused on this fact. Although, due to a limited space this is just a probe into the researched problem, it however, confirms the relevance of these connections. © 2015, Ecozone, OAIMDD. All rights reserved. Source

Benacka J.,Constantine the Philosopher University
Physics Education

This paper gives the solution and analysis of projectile motion in a vacuum if the launch and impact heights are not equal. Formulas for the maximum horizontal range and the corresponding angle are derived. An Excel application that simulates the motion is also presented, and the result of an experiment in which 38 secondary school students developed the application and investigated the system is given. A questionnaire survey was carried out to find out whether the students found the lessons interesting, learned new skills and wanted to model projectile motion in the air as an example of more realistic motion. The results are discussed. © 2015 IOP Publishing Ltd. Source

Palitefka J.,Constantine the Philosopher University
European Journal of Science and Theology

This article thematically monitors two main areas. The first part is devoted to the analysis of the most famous work of Oswald Spengler – „The Decline of the West‟. Attention is paid to the examination of the substance of culture and its life stages. The main emphasis is put on exploring its final stage when the culture dies and changes into civilization. These signs of culture decline are then applied in the second part, which deals with the examination of selected phenomena in the Western civilization. © 2016, Ecozone, OAIMDD. All rights reserved. Source

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