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Poiana C.,Carol Davila University of Medicine and Pharmacy | Poiana C.,Constantin I Parhon National Institute Of Endocrinology | Carsote M.,Carol Davila University of Medicine and Pharmacy | Ardeleanu C.,Victor Babes National Institute | And 5 more authors.
Romanian Journal of Morphology and Embryology | Year: 2011

Thyroid metastasis is atypical. We present a 70-year-old female case that was first diagnosed as gastric cancer after surgical approach. Two years later a thyroidectomy was performed and the immunohistochemistry (IHC) profile revealed a neuroendocrine tumor (NET): poorly differentiated neuroendocrine carcinoma (with small cells), with positive reaction for SYN, CROMO, negative for calcitonin, TTF1 and thyreoglobulin. The Ki-67 index was 25%. Considering the unusual metastasis, the IHC exam of the stomach tumor was performed pointing the same features as the thyroid findings. This proved that the thyroid tumor was a metastasis from a primary gastric neoplasia. This is an unusual case of NET because of the thyroid involvement. Nevertheless, the IHC exam played the major role in elucidating the diagnosis and the prognosis of the case. Source


Barbu C.G.,University of Bucharest | Florin A.,Elias Hospital | Florin A.,Victor Babes National Institute Of Research Development In Pathology And Biomedical Science | Neamtu M.C.,University of Medicine and Pharmacy of Craiova | And 7 more authors.
Romanian Journal of Morphology and Embryology | Year: 2015

Papillary thyroid carcinoma (PTC) is well known as a differentiated thyroid carcinoma with an established treatment protocol and high survival rates. Nevertheless, its tall cell variant (TCV) is more frequent diagnosed with larger tumor size, advanced age and metastasis comparing to other PTC cases, resembling an increased level of aggressiveness attributable to the histological subtype according to recent studies. We present the case of a 60-year-old woman who came for a recently increase of the thyroid and a left laterocervical mass associated with pain and alteration of general status. Thyroidectomy revealed a TCV of PTC with infiltration of the extrathyroid tissue. The laterocervical mass posed difficulties to surgical excision but in a second attempt proved to be an undifferentiated carcinoma. The findings were associated to a rapid deterioration of the patient’s general condition finalized with death within less than three months from the initial presentation. © 2015, Editura Academiei Romane. All rights reserved. Source


Paun D.,University of Bucharest | Paun D.,Constantin I Parhon National Institute Of Endocrinology | Neamtu M.-C.,University of Medicine and Pharmacy of Craiova | Avramescu E.T.,University of Craiova | And 6 more authors.
Romanian Journal of Morphology and Embryology | Year: 2014

Aim: The aim of this study was to make immunohistochemical analyses with Inhibin alpha-subunit, Melan A and MNF116 (pan-Cytokeratin antibody) in pheochromocytomas, because immunohistochemistry is useful for the distinction between adrenal tumors. Patients and Methods: We used 20 patients with pheochromocytomas submitted to laparoscopic (n=19) or classical (n=1) surgery and we have explored immunostaining with Inhibin alpha-subunit, Melan A and MNF116 in these tumors. This can be helpful when we cannot make the distinction between adrenal tumors. Results: Pheochromocytomas did not stain with Inhibin alpha-subunit, Melan A and MNF116. Conclusions: In our study, Inhibin alpha-subunit, Melan A and MNF116 were not sensitive for pheochromocytomas. © 2014 ROMANIAN ACADEMY PUBLISHING HOUSE. All rights reserved. Source


Bumbea H.,Carol Davila University of Medicine and Pharmacy | Badiu C.,Constantin I Parhon National Institute Of Endocrinology | Dobrescu R.,Constantin I Parhon National Institute Of Endocrinology | Vladareanu A.,Carol Davila University of Medicine and Pharmacy
Acta Endocrinologica | Year: 2013

We report the case of a 24 years old male, diagnosed with severe pancytopenia, possibly myelodysplastic syndrome with ringed sideroblasts associated with immune thrombocytopenia, who presented with hyperthyroidism due to Graves' disease. Standard antithyroid drugs were postponed for fear of exacerbation of cytopenia. Instead, steroid and immunoglobulin therapy gradually induced euthyroidism which was followed by correction of the hematological abnormalities. We review in this paper literature reports that discuss the association of thyrotoxicosis with pancytopenia, with reversibility of both the hematological and endocrine autoimmune picture after immunosuppressive treatment. Source


Poiana C.,Carol Davila University of Medicine and Pharmacy | Poiana C.,Constantin I Parhon National Institute Of Endocrinology | Neamtu M.C.,University of Medicine and Pharmacy of Craiova | Avramescu E.T.,University of Craiova | And 8 more authors.
Romanian Journal of Morphology and Embryology | Year: 2013

Dedifferentiation is a process that may be found in metastasis from the neuroendocrine tumors. We present the case of a female within the seventh decade of life incidentally diagnosed with a mature teratoma with element of cartilages, bronchia, mucinous glands, and a poorly differentiated neuroendocrine carcinoma (Ki67 of 30%). After six months of chemotherapy and another six months of disease free interval, a metastasis of the great omentum was removed. The dedifferentiation was diagnosed based on much higher Ki67 (of 70%). The loss of estrogen receptor of 40% from the initial site to 3% into metastasis indicates an exclusive neuroendocrine aggressive pattern. The ovarian carcinoid is a rare situation, and metastasis to the great omentum with dedifferentiation is even seldom. Source

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