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Shah S.,Mgvs Pharmacy College | Mohan M.,Mgvs Pharmacy College | Kasture S.,Mgvs Pharmacy College | Ballero M.,University of Cagliari | And 4 more authors.
Natural Product Research | Year: 2013

Oxidative stress is the main factor in doxorubicin (DOX) induced cardiotoxicity. Wistar rats received either DOX (3 mgkg1, i.p.) every other day or combination of Hypericum hircinum (100 and 200 mgkg1, p.o.) and DOX or H. hircinum (200mg kg1, p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG, heart rate and measuring the levels of cardiac marker enzymes - lactic acid dehydrogenase, creatine phosphokinase, glutamic oxaloacetic transaminase, the antioxidant defence enzymes - reduced glutathione (GSH), superoxide dismutase (SOD) and lipid peroxidative value (LPO) at the end of treatment schedule. Treatment with H. hircinum significantly ( p50.05) decreased the levels of LPO and marker enzymes, increased the levels of GSH and SOD, reversed the changes in ECG and prevented the decrease in heart weight in DOX-treated group. The results suggest that H. hircinum has the potential to prevent the cardiotoxic effects induced by DOX. © 2013 Taylor &Francis.


Serrilli A.M.,Consorzio Interuniversitario per Lo Studio Dei Metaboliti Secondari | Serrilli A.M.,University of Rome La Sapienza | Sanfilippo V.,University of Rome La Sapienza | Ballero M.,Consorzio Interuniversitario per Lo Studio Dei Metaboliti Secondari | And 9 more authors.
Natural Product Research | Year: 2010

Secondary metabolite isolation and analysis of Plumbago europaea L. (Plumbaginaceae) is the aim of this work, which is included in a project of our groups on spontaneous and endemic Sardinian species. Plumbago europaea is the only specie of the genera that grows wild in Italy. Metabolites from leaves and roots of this specie were compared. Moreover, at present, literature on the phytochemical characterisation of P. europaea is poor. Plumbagin was isolated in both of the samples analysed, confirming its nature in the Plumbaginaceae family as chemotaxonomic marker of the Plumbaginae tribe. In this work, hydroplumbagin-4-O-glucoside and myricetin-3-O-rhamnoside are isolated for the first time in the genus. © 2010 Taylor & Francis.


Serrilli A.M.,Consorzio Interuniversitario per Lo Studio Dei Metaboliti Secondari | Serrilli A.M.,University of Rome La Sapienza | Graziosi V.,Consorzio Interuniversitario per Lo Studio Dei Metaboliti Secondari | Graziosi V.,University of Rome La Sapienza | And 12 more authors.
Natural Product Research | Year: 2010

The flavonoid fraction of the aerial parts of Genista cadasonensis Valsecchi (Leguminosae), an endemic plant from Sardinia, was examined and compared with the flavonoid pattern already known in the Genista genus. This comparison evidenced the endemic nature of this species, showing the presence of a rare flavonoid, the 6-hydroxy-genistein. The antioxidant activity of dichloromethanic, ethanolic and acetonic total extracts of aerial parts was evaluated. © 2010 Taylor & Francis.


PubMed | Consorzio Interuniversitario per lo Studio dei Metaboliti Secondari
Type: Journal Article | Journal: Natural product research | Year: 2010

Secondary metabolite isolation and analysis of Plumbago europaea L. (Plumbaginaceae) is the aim of this work, which is included in a project of our groups on spontaneous and endemic Sardinian species. Plumbago europaea is the only specie of the genera that grows wild in Italy. Metabolites from leaves and roots of this specie were compared. Moreover, at present, literature on the phytochemical characterisation of P. europaea is poor. Plumbagin was isolated in both of the samples analysed, confirming its nature in the Plumbaginaceae family as chemotaxonomic marker of the Plumbaginae tribe. In this work, hydroplumbagin-4-O-glucoside and myricetin-3-O-rhamnoside are isolated for the first time in the genus.

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