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Hajji L.,University of Almeria | Saraiba-Bello C.,University of Almeria | Romerosa A.,University of Almeria | Segovia-Torrente G.,University of Almeria | And 4 more authors.
Inorganic Chemistry | Year: 2011

The new water-soluble ruthenium(II) mononuclear complexes [RuCp(X)(PTA)(L)] (X = 8-thio-theophyllinate (TTH- ), L = PTA (1), L = PPh 3 (7)); (X = 8-methylthio-theophyllinate (8-MTT-), L = PTA (2), L = PPh 3 (8)), (X = 8-benzylthio-theophyllinate (8-BzTT-), L = PTA (3), L = PPh 3 (9)) and binuclear complexes [{RuCp(PTA)(L)} 2-μ-(Y-κN7,N,7)] (Y = bis(S-8-thiotheophyllinate)methane (MBTT2-), L = PTA (4), L = PPh 3 (10)), (Y = 1,2-bis(S-8-thiotheophyllina-te)ethane (EBTT2-), L=PTA (5), L=PPh 3 (11)), (Y=1,3-bis(S-8-thiotheophyllinate)propane (PBTT2-); L=PTA (6), L=PPh 3 (12)) have been synthesized and characterized by NMR, IR spectroscopy and elemental analysis. The single crystal X-ray structure of [RuCp(8-MTT-κS)(PTA) 2](2) was also obtained. The antiproliferative activity of the complexes on c/splatin-sensitive T2 and c/splatin-resistant SKOV3 cell lines has been evaluated. © 2011 American Chemical Society. Source


Oliveri V.,University of Catania | Oliveri V.,Consorzio Interuniversitario Of Ricerca In Chimica Dei Metalli Nei Sistemi Biologici | Bellia F.,CNR Institute of Biostructure and Bioimaging | Pietropaolo A.,University of Catanzaro | Vecchio G.,University of Catania
Chemistry - A European Journal | Year: 2015

Mounting evidence suggests an important role of cyclodextrins in providing protection in neurodegenerative disorders. Metal dyshomeostasis is reported to be a pathogenic factor in neurodegeneration because it could be responsible for damage involving oxidative stress and protein aggregation. As such, metal ions represent an effective target. To improve the metal-binding ability of cyclodextrin, we synthesized three new 8-hydroxyquinoline-cyclodextrin conjugates with difunctionalized cyclodextrins. In particular, the 3-difunctionalized regioisomer represents the first example of cyclodextrin with two pendants at the secondary rim, resulting in a promising compound. The derivatives have significant antioxidant capacity and the powerful activity in inhibiting self-induced amyloid-β aggregation seems to be led by synergistic effects of both cyclodextrin and hydroxyquinoline. Moreover, the derivatives are also able to complex metal ions and to inhibit metal-induced protein aggregation. Therefore, these compounds could have potential as therapeutic agents in diseases related to protein aggregation and metal dyshomeostasis. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Turnaturi R.,University of Catania | Oliveri V.,University of Catania | Oliveri V.,Consorzio Interuniversitario Of Ricerca In Chimica Dei Metalli Nei Sistemi Biologici | Vecchio G.,University of Catania
Polyhedron | Year: 2016

Metal dyshomeostasis and oxidative stress have been linked to numerous diseases such as Alzheimer's and Parkinson's diseases, cancer and so forth. Herein, we report the synthesis, chelating and antioxidant ability of two novel derivatives of biotin endowed with an 8-hydroxyquinoline moiety. This family of chelators under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis. The biotin-8-hydroxyquinoline conjugates and their metal complexes with manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) were characterized by several techniques such as NMR, ESI-MS and UV-Vis. Moreover, the capacity of these ligands and complexes to act as antioxidants was evaluated. The collected information may provide new insights and suggest further strategies for the development of 8-hydroxyquinoline derivatives for the control of metal dyshomeostasis and oxidative stress. © 2016 Elsevier Ltd. All rights reserved. Source


Sgarlata C.,University of Catania | Oliveri V.,University of Catania | Oliveri V.,Consorzio Interuniversitario Of Ricerca In Chimica Dei Metalli Nei Sistemi Biologici | Spencer J.,University of Sussex
European Journal of Inorganic Chemistry | Year: 2015

Chelating agents offer a versatile and effective means of removing toxic metal ions from the human body. Mounting evidence suggests that exposure to nickel and cobalt causes a number of adverse nasal/pulmonary health effects, skin hazards and allergies. In this context, the development of chelators that are able to bind nickel and cobalt with high stability constants is clearly crucial. Herein, the interaction of cobalt(II) and nickel(II) with a 8-hydroxyquinoline-cyclodextrin conjugate was investigated in aqueous solution at neutral pH. This family of chelator under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis. Stability constants for the cobalt(II) and nickel(II) complexes were determined by competition experiments. The data indicate the formation of stable complexes, which were characterized by spectroscopic techniques. The collected information may provide new insights and suggest further strategies for the development of hydroxyquinoline derivatives for the control of cobalt and nickel toxicity. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source


Casella G.,University of Palermo | Casella G.,Consorzio Interuniversitario Of Ricerca In Chimica Dei Metalli Nei Sistemi Biologici | Ferrante F.,University of Palermo | Saielli G.,CNR Institute on Membrane Technology
Polyhedron | Year: 2016

We have tested several DFT protocols, at the non-relativistic and relativistic ZORA (scalar and spin-orbit) levels, for the calculation of the 113Cd chemical shifts, δ(113Cd), for a number of cadmium complexes accounting for both different local coordination environments on the metal center, involving N, O and S ligands, and different geometrical arrangements. Moreover, suitable models as reference compounds for δ(113Cd) evaluation have been set up in order to propose a complete computational approach to calculate δ(113Cd) for cadmium complexes. Inclusion of relativistic corrections did not lead to any sensible improvement in the quality of results and, in this context, non-relativistic method, namely: B3LYP/Sadlej(Cd); 6-31g(d,p) (light atoms), showed to be the best approach to calculate δ(113Cd) for the classes of compounds investigated. © 2016 Elsevier Ltd. All rights reserved. Source

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