University of Dundee, Medivir Ab, Consejo Superior De Investigaciones Cientificas, Swiss Tropical, Public Health Institute and SYNGENE INTERNATIONAL Ltd PLC | Date: 2015-06-09
The invention provides compounds of the formula: wherein L^(1 )and L^(2 )are independently selected from O and S; R^(1 )is C_(3)-C_(6 )straight or branched alkyl, C_(3)-C_(7)cycloalkyl, C_(5)-C_(7)cycloalkenyl, adamantly, phenyl or saturated heterocyclyl, any of which being optionally substituted; R^(2 )is H, methyl or ethyl; R^(5 )is NRxCORy, NRxRy, CH_(2)COCH_(3), CH_(2)CN, or a 5- or 6-membered heteroaryl group which is optionally substituted; X, Y and Z are independently N or CH; Rx is independently H or C_(1)-C_(4)alkyl; Ry is independently H, CrC4alkyl, phenyl or benzyl, either of which is optionally substituted; n is 0-3; salts, hydrates and N-oxides, wherein the optional substituents are further defined in the claims. The compounds have utility in the prophylaxis or treatment of trypanosomal diseases, such as T. cruzi (Chagas disease).
Consejo Superior De Investigaciones Cientificas and Ecole Polytechnique - Palaiseau | Date: 2015-03-27
An acquisition device (20) comprising a wall and a transducer (23) constituted by a body (24, 324) on which electrodes (25) are fastened spaced apart from one another. An electrical impedance (R) of the transducer is variable as a function of deformation of the transducer. When looking in a direction perpendicular to a surface (36) of the wall, at least two electrodes (25) of said plurality of electrodes are spaced apart from each other. The transducer is incorporated under the surface (36) of the wall.
Rovira i Virgili University, Consejo Superior De Investigaciones Cientificas, University of Vigo, University of Marburg and Medcomtech S.A. | Date: 2017-03-29
A silicon particle comprising a silicon body, a functionalized silica surface surrounding the silicon body, and a targeting moiety specifically targeting tumor cells, and, optionally, an enzymatically metabolizable compound,is useful in the treatment of cancer by producing cell death after particle internalization.
Consejo Superior De Investigaciones Cientificas, Fundacio Clinic Per A La Recerca Biomedica and University of Barcelona | Date: 2017-06-21
The invention relates to the use of mitochondrial DNA as a quantitative biomarker for the sub-classification of patients suffering from Parkinson disease in the subgroups of familial or idiopathic Parkinson. The invention also relates to a method and to a kit for the sub-classification of patients suffering from Parkinson disease using said biomarker.
Consejo Superior De Investigaciones Cientificas and Simon Fraser University | Date: 2017-06-21
The present invention relates to a power source based on a capillary-based microfluidic redox flow cell made from cellulose and carbon materials which are completely safe and non-toxic, yet inexpensive. The power will be generated by electrochemical reactions facilitated by flowing redox species through porous electrodes. These organic substances will be stored in the capillary-based microfluidic redox flow cell and recover their initial structure upon the addition of any liquid, such as wastewater, seawater, urine, that can even be the same sample to be analyzed. The mass transport within the power source will entirely rely on capillary flow through the different porous materials. Hence, the power source will not require a pump to operate. Once the capillary-based microfluidic redox flow cell is completely wet and the species oxidized/reduced, the power source can be disposed with no environmental impact, as it does not contain any metals or harmful substances.
Consejo Superior De Investigaciones Cientificas | Date: 2016-10-12
The present invention relates to a composition that comprises the peptide QBP1 for use in the inhibition of memory consolidation, after a trauma, more preferably in Post-Traumatic Stress Disorder or related diseases.
Consejo Superior De Investigaciones Cientificas | Date: 2016-06-15
Derivatives of 2-phenyl-7,7a-dihydro-3aH-pyrano[3,4-d]oxazole-6(4H)-one of formula I where the meanings for the substituents are those listed in the description. These compounds are useful as inhibitors of HIF-2 and SOX-2.
Consejo Superior De Investigaciones Cientificas and Centro Tecnologico Vidres S.L. | Date: 2016-10-05
The present invention relates to an albite and/or anorthite glass ceramic material, which exhibits a sensation of thermal warmth and its production process. Furthermore, the present invention relates to the use of this glass-ceramic material for the manufacturing of industrial, structural and ornamental ceramic products.
Consejo Superior De Investigaciones Cientificas | Date: 2016-08-31
This invention discloses a method for preparing a thermochemical energy storage material comprising CaO or Ca(OH)_(2). The material also comprises a matrix of hard cementitious material containing silica and calcium silicates that result from the reaction of a binder, such as Na_(2)Si_(3)O_(7), with the external part of the CaO particles originally embedded in the binder. The cementitious material is characterized by the secondary products of a reaction of the calcium silicates with CO_(2) at high temperature followed by a calcination step of all formed carbonates. The resulting material displays superior mechanical and chemical properties after many reversible cycles of hydration with H_(2)O_((v)) and dehydration of Ca(OH)_(2) and can be used for thermochemical energy storage systems.
Consejo Superior De Investigaciones Cientificas | Date: 2016-11-30
The invention provides an optoelectronic device comprising a porous material and a material with perovskite crystal structure in contact with the porous material. The porous material is further characterised in that the pores present a well defined average size, in the range of 1-100nm, and characterised in that it is an ordered network which shows a periodicity in one, two or three spatial directions. The perovskite material is infiltrated within the porous material, resulting in a mesostructured and ordered perovskite material. This spatially confined perovskite shows a luminescent emission whose range of wavelengths can be modified changing the pore size of the mesostructure. This invention solves the problem of tuning the emission of perovskite materials without varying their composition. The invention can be used as both light emitting and photovoltaic devices.