Conseil General des Alpes Maritimes

Nice, France

Conseil General des Alpes Maritimes

Nice, France
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Wagner-Mahler K.,Nice University Hospital Center | Kurzenne J.-Y.,Nice University Hospital Center | Delattre I.,Conseil General Des Alpes Maritimes | Berard E.,Nice University Hospital Center | And 11 more authors.
International Journal of Andrology | Year: 2011

To assess the incidence and risk factors of cryptorchidism in Nice area. A 3-year prospective study was conducted at two maternity wards involving neonatal screening of boys born ≥34weeks of amenorrhoea. Methodology was strict with examination at birth, 3 and 12months by the same paediatrician. Two strictly matched controls were included for each case. Information on child and parents (medical history, pregnancy, lifestyle) was recorded using medical chart and self-administered questionnaires. A total of 102 of 6246 boys were born with cryptorchidism (prevalence 1.6%, 95 included). Half of them were still cryptorchid at three and 12months with, however, 10% of secondary re-ascent (recurrent cryptorchidism) at 12months, justifying long-term follow-up. Cryptorchidism at birth was associated with instrumental delivery, inguinal hernia and urogenital malformations, particularly micropenis and paternal history of cryptorchidism. Our results suggest that maternal exposure to anti-rust or phthalates could be a risk factor, whereas eating fruits daily seemed somewhat protective. Prevalence of cryptorchidism in our area is on the lower bracket compared with other countries, and is associated with both familial and environmental risk factors. © 2011 The Authors. International Journal of Andrology © 2011 European Academy of Andrology.

Lorente N.,Institute National Of La Sante Et Of La Recherche Medicale U912 Sesstim | Lorente N.,Aix - Marseille University | Preau M.,Institute National Of La Sante Et Of La Recherche Medicale U912 Sesstim | Preau M.,University of Lyon | And 15 more authors.
PLoS ONE | Year: 2013

Background:Little is known about the public health benefits of community-based, non-medicalized rapid HIV testing offers (CBOffer) specifically targeting men who have sex with men (MSM), compared with the standard medicalized HIV testing offer (SMOffer) in France. This study aimed to verify whether such a CBOffer, implemented in voluntary counselling and testing centres, could improve access to less recently HIV-tested MSM who present a risk behaviour profile similar to or higher than MSM tested with the SMOffer.Method:This multisite study enrolled MSM attending voluntary counselling and testing centres' during opening hours in the SMOffer. CBOffer enrolees voluntarily came to the centres outside of opening hours, following a communication campaign in gay venues. A self-administered questionnaire was used to investigate HIV testing history and sexual behaviours including inconsistent condom use and risk reduction behaviours (in particular, a score of "intentional avoidance" for various at-risk situations was calculated). A mixed logistic regression identified factors associated with access to the CBOffer.Results:Among the 330 participants, 64% attended the CBOffer. Percentages of inconsistent condom use in both offers were similar (51% CBOffer, 50% SMOffer). In multivariate analyses, those attending the CBOffer had only one or no test in the previous two years, had a lower intentional avoidance score, and met more casual partners in saunas and backrooms than SMOffer enrolees.Conclusion:This specific rapid CBOffer attracted MSM less recently HIV-tested, who presented similar inconsistent condom use rates to SMOffer enrolees but who exposed themselves more to HIV-associated risks. Increasing entry points for HIV testing using community and non-medicalized tests is a priority to reach MSM who are still excluded. © 2013 Lorente et al.

Brucker-Davis F.,Nice University Hospital Center | Wagner-Mahler K.,Nice University Hospital Center | Bornebusch L.,CHG Grasse | Delattre I.,Conseil General des Alpes Maritimes | And 8 more authors.
Chemosphere | Year: 2010

In utero and lactational exposure to endocrine disruptors is thought to be potentially harmful on fetal and infant development. Data of exposure in France is scarce.This is a prospective study with (1) collection of 84 cord bloods (CB) and 69 milks from 86 mothers delivering healthy boys (gestational age ≥34. weeks) at two maternity wards in Southern France, between 2002 and 2005 and (2) screening for 15 xenobiotics with anti-androgenic and/or estrogenic effects: DDE, 7 PCBs, dibutylphthalate and its metabolite mBP, HCB, lindane, linuron, procymidone and vinclozoline. Correlations were made with delivery and neonatal outcomes.All CB and milks were contaminated by one or more xenobiotics (mainly PCBs, DDE, HCB, and phthalates) with good correlation between CB and milk concentrations. Compared to other geographical areas, exposure was usually in the lower bracket. Milk [PCB180] was associated with lower birth weight. Infant head circumference correlated negatively with [HCB] and positively with [mBP] in CB. There was a similar but not significant trend for birth weight and length. [DDE] in milk was higher in older mothers and in women born in Africa.In utero and lactational exposure is ubiquitous in our area. Contamination of milk with HCB, mBP, and PCB 180 showed weak correlations with infant growth. This snapshot of exposure in an area with no major industry will serve for further monitoring. © 2010 Elsevier Ltd.

Pulcini C.,Nice University Hospital Center | Pulcini C.,University of Nice Sophia Antipolis | Pulcini C.,Montpellier University | Naqvi A.,Nice University Hospital Center | And 5 more authors.
Medecine et Maladies Infectieuses | Year: 2010

Objective: The study's objective was to assess General Practitioners' (GPs) perceptions of their antibiotic prescribing practice and of bacterial resistance. Design: We surveyed a random sample of 102 GPs out of the 1242 working in the Alpes-Maritimes area (France). Results: The response rate was 69%. More than 80% of the GPs felt confident when prescribing an antibiotic. The two main factors thought to influence their antibiotic prescriptions were their previous experience (97%) and guidelines (81%), advice from a colleague was quoted by only 13% of the GPs. Antibiotic resistance was perceived as a national problem by 91% of the respondents, but only 65% rated the problem as important in their own daily practice. Widespread and inappropriate antibiotic use, prescription of broad spectrum antibiotics or too low antibiotic doses were rated as important causes of resistance, but excessive duration of antibiotic treatment or poor hand hygiene practices were cited less often. The three measures perceived to be helpful or very helpful to improve antibiotic prescribing by more than 80% of the GPs were training sessions, availability of guidelines and of resistance data. Conclusions: These perceptions must be taken into account to maximize adherence of GPs to the measures intended to limit bacterial resistance. © 2010 Elsevier Masson SAS.

Beltrami M.E.,Center for Technology Transfer | Blanco S.,University of León | Scheidecker N.,Conseil General des Alpes Maritimes | Ciutti F.,Center for Technology Transfer | And 4 more authors.
Diatom Research | Year: 2010

A new benthic diatom species, Gomphonema vidalii sp. nov., is described with light (LM) and scanning electron microscopy (SEM) observations. It was found in three Mediterranean watercourses: Farfa (Central Italy), Bévéra (France and Italy) and Paillon streams (SouthEastern France). Valves have a clavate shape and striae are slightly radial, the central ones being shorter than the others; one stigma is present in the central area. G. vidalii belongs to the group of Gomphonema species with doubly-punctate striae, a feature which is considered by some authors typical of the genus Gomphoneis. Distinct to Gomphonema vidalii is the presence of stigmoid areolae in the central area, different in structure from stigmata and stigmoids which can be found in some Gomphonema and Gomphoneis species.

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