Pundir J.,Assisted Conception Unit |
Pundir V.,Conquest |
Omanwa K.,Assisted Reproduction and Gynaecology Center |
Khalaf Y.,Assisted Conception Unit |
El-Toukhy T.,Assisted Conception Unit
Reproductive BioMedicine Online | Year: 2014
This systematic review and meta-analysis investigated the use of routine hysteroscopy prior to starting the first IVF cycle on treatment outcome in asymptomatic women. Searches were conducted on MEDLINE, EMBASE, Cochrane Library, National Research Register and ISI Conference Proceedings. The main outcome measures were clinical pregnancy and live birth rates achieved in the index IVF cycle. One randomized and five non-randomized controlled studies including a total of 3179 participants were included comparing hysteroscopy with no intervention in the cycle preceding the first IVF cycle. There was a significantly higher clinical pregnancy rate (relative risk, RR, 1.44, 95% CI 1.08-1.92, P = 0.01) and LBR (RR 1.30, 95% CI 1.00-1.67, P = 0.05) in the subsequent IVF cycle in the hysteroscopy group. The number needed to treat after hysteroscopy to achieve one additional clinical pregnancy was 10 (95% CI 7-14) and live birth was 11 (95% CI 7-16). Hysteroscopy in asymptomatic woman prior to their first IVF cycle could improve treatment outcome when performed just before commencing the IVF cycle. Robust and high-quality randomized trials to confirm this finding are warranted. Currently, there is evidence that performing hysteroscopy (camera examination of the womb cavity) before starting IVF treatment could increase the chance of pregnancy in the subsequent IVF cycle in women who had one or more failed IVF cycles. However, recommendations regarding the efficacy of routine use of hysteroscopy prior to starting the first IVF treatment cycle are lacking. We reviewed systematically the trials related to the impact of hysteroscopy prior to starting the first IVF cycle on treatment outcomes of pregnancy rate and live birth rate in asymptomatic women. Literature searches were conducted in all major database and all randomized and non-randomized controlled trials were included in our study (up to March 2013). The main outcome measures were the clinical pregnancy rate and live birth rate. The secondary outcome measure was the procedure related complication rate. A total of 3179 women, of which 1277 had hysteroscopy and 1902 did not have a hysteroscopy prior to first IVF treatment, were included in six controlled studies. Hysteroscopy in asymptomatic woman prior to their first IVF cycle was found to be associated with improved chance of achieving a pregnancy and live birth when performed just before commencing the IVF cycle. The procedure was safe. Larger studies are still required to confirm our findings. © 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Ypsilantis E.,Conquest |
Tang T.Y.,University of Cambridge
Annals of Vascular Surgery | Year: 2010
Background: Chronic stump and phantom limb pain after amputation for critical ischemia significantly affect patients' quality of life and pose challenging clinical problems. Pre-emptive analgesia attempts to prevent chronic postoperative pain by minimizing painful stimuli before and during surgery. Methods: This systematic literature review aimed to evaluate the evidence supporting the use of pre-emptive analgesia in minimizing the risk of chronic stump and phantom pain after lower limb amputation for critical ischemia of peripheral vascular disease. Results: A total of 11 studies have been retrieved. Five different types of analgesic drugs were evaluated (local anesthetics, opiates, N-methyl-d-aspartate receptor antagonists, a2-agonist, and gamma-aminobutyric acid analogues), administered separately or in combinations, through the oral, intravenous, epidural, or regional (perineural) route. The beneficial effect of combined bupivacaine, diamorphine, and clonidine in reducing the risk of phantom limb pain was supported by only one study (level 3 evidence). Epidural and perineural infusions containing local anesthetic ± opiates are effective in treating acute perioperative pain, although not without potentially serious complications. Most studies were characterized by high drop-out rates because of disease-associated mortality. Conclusions: There is no robust evidence supporting the use of pre-emptive analgesia to minimize the risk of chronic pain after amputation for critical ischemia of peripheral vascular disease. The methods used are, however, effective in treating acute postoperative pain. © Annals of Vascular Surgery Inc.
Journal of perioperative practice | Year: 2012
The use of medical devices is an increasingly important element of a healthcare professional's role. It is crucial that users receive regular teaching and education to ensure that they are competent in the use of devices. This is particularly relevant in the increasingly litigious society in which we live. This article focuses upon the importance of a medical device education.
BMJ case reports | Year: 2012
Blunt ocular trauma from a child's plastic foam-covered toy baseball bat caused traumatic optic neuropathy and choroidal rupture in a 9-year-old child. The examination revealed a visual acuity of 6/60, a relative afferent pupillary defect, optic nerve swelling, commotio retinae and retinal haemorrhages. There was no orbital fracture or intraorbital haematoma on CT scanning. Optical coherence tomography showed macular oedema and disruption of the retinal pigment epithelium and Bruch's membrane. The child was admitted for intravenous methylprednisolone and discharged on topical steroid treatment. At 1 month follow-up, visual acuity had improved to 6/12. Optic nerve swelling had resolved and the fundus had two crescent-shaped choroidal rupture scars. Choroidal rupture and optic neuropathy can be secondary to indirect trauma, and even when the mechanism of injury is with a piece of equipment designated as suitable for children, serious ocular injury can occur.
Sinha P.,Conquest |
Journal of Obstetrics and Gynaecology | Year: 2012
In the last decade, diagnosis of caesarean scar (CS) pregnancy and abnormal placental invasion has gone up significantly. It appears that the history of previous caesarean section is the predisposing factor common to both conditions. Until now, these are treated as a separate entity and therefore managed differently. Recent available evidence suggests that these are not a separate entity but rather a continuum of the same condition. If the caesarean scar pregnancy is managed expectantly in the 1st trimester, most likely it evolves into placenta accreta. This leads invariably to peripartum hysterectomy for postpartum haemorrhage (PPH) and severe maternal morbidity. Early diagnosis and intervention may give a favourable outcome. © 2012 Informa UK, Ltd.
Conquest | Date: 2013-04-29
Aspects of the present invention are generally directed to a biopsy device configured to engage target tissue within a patient and to remove a sample of the target tissue from the patient. The biopsy device comprises an elongate catheter configured to be inserted into a patient. A coring component is disposed at the distal end of the catheter to sample the target tissue.
Conquest | Date: 2016-04-25
Conquest | Date: 2016-08-08
Dietary and nutritional supplements; Dietary and nutritional supplements for endurance sports; Dietary and nutritional supplements used for weight loss.
News Article | July 11, 2015
BITS Pilani, one of India’s top tech universities’ Center for Entrepreneurial Leadership (CEL), organised mentorship program Conquest in Mumbai this week. The program, which aims to mentor 50 startups from second- and third-tier cities in India, provides mentorship on fundraising, revenue model refining, customer acquisition, hiring and grooming talent, up-scaling, marketing, and technology. The organisers received 1,500 registrations. According to Conquest marketing manager Devanshi Kotak, the teams were assessed on their idea and business plan. Conquest has organised similar mentorship programs in Delhi, Bangalore, Chennai, and Hyderabad. Meet the startups that made it to the Mumbai leg: Llynkr: Llynkr is a communication tool for preschools and parents. The startup’s ERP system ensures that parents get alerts on leaves in school and events such as fancy dress days. Janta Choupal: Janta Choupal is an app that connects users with their elected representative to improve social governance of the area. The startup aims to connect people with not just a local representative but also corporators, chief ministers, members of parliament, and members of legislative assembly. It also helps elected representatives have a common platform to interact with their actual voters. Frapp: Frapp is a deals and discounts app for verified students, who constitute a large chunk of India’s population and are the customers of the future for brands. According to the company, brands face a lot of problems in finding initial engagement with youngsters. Shop Elect: Shop Elect is an ecommerce site for industrial products that converts the traditional business of electrical distribution into a professionally-managed, technology-driven ecommerce organization. Interview Mocha: It is a pre-employment skill testing solution provider for multiple profiles. The combinations of questions are made after conducting market research for the job profile in question. Art and Found: Art and Found is an online platform for artists to showcase, share, and sell their work. The artists’ community in India is disorganised and underpaid. Most of them don’t have a means to make their art accessible to art buyers. Tech Innovance: Tech Innovance is a home automation company that allows you to remotely control your programmable thermostat, lights, security systems, garage doors, sprinklers, TVs, home audio systems, DVRs, and kitchen appliances from anywhere in the world. Hero: Hero is an aggregator of all online marketplaces. It brings the point of sale to consumers through its app and also Whatsapp and FaceBook messenger. Wockito: Wockito is an app for users to exchange contact details. Helmatron: It manufactures smart helmets for tracking bikes, curbing vehicle thefts, and drunk driving. The helmet analyses the alcohol content in the driver’s breath and directs the vehicle through a wireless signal to start or stop accordingly. The encryption technology used in the helmet will greatly help in reducing bike thefts. Longman Suntech Energy: It sells green power from onsite rooftop solar power plants at tariffs lower than the grid tariff.