Mequon, WI, United States

Concordia University at Wisconsin
Mequon, WI, United States

Concordia University Wisconsin is a private liberal arts college located in Mequon, Wisconsin. The school is an affiliate of the 10-member Concordia University System operated by the Lutheran Church–Missouri Synod .The university is a coeducational institution accredited by the NCA, with 78 undergraduate majors and minors, 17 graduate programs, eight accelerated adult education programs and three doctoral/professional programs, and accelerated evening and e-learning programs. Doctoral degrees are offered in pharmacy, physical therapy, and nursing practice. CUW also has 10 classroom centers providing community outreach with full adult education and post-graduate programs. CUW's School of Pharmacy is one of only two pharmacy schools in Wisconsin - the other being the University of Wisconsin-Madison.The university is organized into five schools or colleges: the School of Education, the School of Business and Legal Studies, the School of Human Services, the School of Arts and science, and the School of Adult and Continuing Education.The university's mission statement reads: "Concordia University Wisconsin is a Lutheran higher education community committed to helping students develop in mind, body, and spirit for service to Christ in the Church and the world."Concordia University Wisconsin is currently merging with Concordia University Ann Arbor due to CUAA's financial troubles. Concordia University Ann Arbor has since undergone significant renovations. Wikipedia.

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Hoffmann B.R.,Medical College of Wisconsin | El-Mansy M.F.,Marquette University | Sem D.S.,Marquette University | Sem D.S.,Concordia University at Wisconsin | Greene A.S.,Medical College of Wisconsin
Journal of Medicinal Chemistry | Year: 2012

Drugs exert desired and undesired effects based on their binding interactions with protein target(s) and off-target(s), providing evidence for drug efficacy and toxicity. Pioglitazone and rosiglitazone possess a common functional core, glitazone, which is considered a privileged scaffold upon which to build a drug selective for a given target-in this case, PPARγ. Herein, we report a retrospective analysis of two variants of the glitazone scaffold, pioglitazone and rosiglitazone, in an effort to identify off-target binding events in the rat heart to explain recently reported cardiovascular risk associated with these drugs. Our results suggest that glitazone has affinity for dehydrogenases, consistent with known binding preferences for related rhodanine cores. Both drugs bound ion channels and modulators, with implications in congestive heart failure, arrhythmia, and peripheral edema. Additional proteins involved in glucose homeostasis, synaptic transduction, and mitochondrial energy production were detected and potentially contribute to drug efficacy and cardiotoxicity. © 2012 American Chemical Society.

Traynor L.M.,Concordia University at Wisconsin | Thiessen C.N.,Gateway Family Health Clinic Ltd. | Traynor A.P.,Concordia University at Wisconsin
American Journal of Health-System Pharmacy | Year: 2011

Purpose. Published evidence on the pathophysiology, diagnosis, and treatment of fibromyalgia is reviewed, with an emphasis on recent clinical trials of various pharmacologic agents. Summary. Fibromyalgia affects an estimated 2% of the general U.S. population, and its incidence is sevenfold higher among women. The diagnostic characteristics of fibromyalgia are chronic widespread pain, thought to arise from abnormalities of ascending pain and descending inhibitory sensory pathways, and allodynia on palpation of specific tender points. Three medications available in the United States are labeled for treatment of fibromyalgiarelated symptoms: the serotonin- and norepinephrine-reuptake inhibitors duloxetine and milnacipran and the α 2-δ ligand pregabalin. Evidence from clinical trials indicates that all three drugs can have a significant impact on fibromyalgia-related pain; duloxetine and pregabalin have been demonstrated to reduce sleep disturbances and improve quality of life (the former also has been shown to improve mood), while milnacipran can offer significant benefits in reducing fatigue. A growing body of evidence suggests that the best treatment approach may involve the use of one or more agents whose mechanisms of action are aligned with patient-specific clusters of symptoms. Several other agents have been used for fibromyalgia, with mixed results, including tricyclic antidepressants, selective serotonin-reuptake inhibitors, opioids, and gabapentin. Given the limitations of the evidence from clinical trials to date, controlled trials directly comparing different agents are needed to better delineate adverse-event risks, cost considerations, and optimal management approaches. Conclusion. A broad range of drugs has been used to treat fibromyalgia. Symptoms, comorbidities, adverse effects, and patient preference are important considerations in drug selection. Copyright © 2011, American Society of Health-System Pharmacists, Inc. All rights reserved.

Von Der Heyde R.,Concordia University at Wisconsin
Journal of Hand Therapy | Year: 2015

Research pertaining to the rehabilitation of children with flexor tendon injuries is less prevalent than that in the adult population, and most authors agree that immobilization protocols comprise a safe and efficacious choice. This article presents suggested protocols and correlated literature regarding the outcomes of immobilization, early passive motion, and early active motion in the pediatric population. Confounding factors which influence rehabilitative choices, both personal and environmental, are also presented. © 2015 Hanley & Belfus, an imprint of Elsevier Inc. All rights reserved.

Lemley K.J.,Marquette University | Lemley K.J.,Concordia University at Wisconsin | Drewek B.,Marquette University | Hunter S.K.,Marquette University | Hoeger Bement M.K.,Marquette University
Medicine and Science in Sports and Exercise | Year: 2014

INTRODUCTION: This study assessed the effect of isometric contractions that varied in intensity and duration on pain perception in adults older than 60 yr. METHODS: Pain perception was measured in 24 men and women (mean ± SD age = 72.2 ± 6.2 yr) using a pressure pain device applied to the right index finger before and after isometric contractions of the left elbow flexor muscles of the following doses: 1) three brief maximal voluntary contractions (MVC), 2) 25% MVC held for 2 min, and 3) 25% MVC held to task failure. RESULTS: Older adults reported increased pain thresholds (58 s vs 49 s, P < 0.001) and decreased pain ratings (2.8 vs 3.4, P < 0.001) after exercise, and these changes were similar across all three tasks (P = 0.94 and P = 0.55, respectively). Sex differences were identified with older women reporting greater pain sensitivity (lower pain thresholds [P = 0.01] and higher pain ratings [P = 0.004]) and larger reductions in pain ratings than men (23% vs 9%, P = 0.003) after isometric contractions. CONCLUSIONS: Older adults experienced similar reductions in pain after several different intensities and durations of isometric contractions. Both older men and women experienced increases in pain threshold, but only older women experienced reductions in pain ratings. Copyright © 2013 by the American College of Sports Medicine.

Lemley K.J.,Marquette University | Lemley K.J.,Concordia University at Wisconsin | Hunter S.K.,Marquette University | Bement M.K.H.,Marquette University
Medicine and Science in Sports and Exercise | Year: 2015

Introduction: Conditioned pain modulation (CPM) is the concept that pain inhibits pain and has potential rehabilitation implications for exercise prescription. The purpose of this study was to determine whether changes in pressure pain perception after a thermal conditioning stimulus (i.e., CPM) was attenuated with aging and whether CPM predicted pain relief after exercise (exercise-induced hypoalgesia (EIH)) in healthy young and older adults. Methods: Twenty young (21.9 ± 3.3 yr, 10 men) and 19 older (72.0 ± 4.5 yr, 10 men) adults participated in three sessions: one familiarization and two experimental (EIH and CPM) sessions. Pressure pain perception was assessed using a weighted Lucite edge placed on the right index finger for 1 min. EIH was determined by measuring pressure pain perception before and after prolonged submaximal isometric contraction of the elbow flexors. CPM was assessed by measuring pressure pain perception at the finger while the foot was immersed in neutral water versus painful ice water. Results: Young, but not older, adults reported a decrease in pressure pain at the finger while their foot was immersed in the ice water bath compared with the neutral bath (i.e., CPM, trial-age: P = 0.001). Pressure pain ratings decreased after exercise (P = 0.03) that was perceived as painful (peak arm pain, 7.0 ± 3.3) for both young and older adults. Regression analysis showed that after controlling for age and baseline pain, CPM predicted EIH (model adjusted R2 = 0.23, P = 0.007). Conclusions: CPM was attenuated in older adults, as measured with a noxious pressure stimulus after a thermal conditioning stimulus, and adults with greater CPM were more likely to report greater EIH. Copyright © 2014 by the American College of Sports Medicine.

Voss K.E.,Concordia University at Wisconsin
Christian Bioethics | Year: 2015

This essay will focus on an evaluation of authoritative documents of the Lutheran Church-Missouri Synod (LCMS) as they are applied to the moral status of the human embryo, reproduction, in vitro fertilization, and prenatal genetic testing. A research project compared religious beliefs and reproductive counseling practices of Roman Catholic priests, pastors from the LCMS, and rabbis affiliated with the Conservative branch of Judaism. A significant part of that study involved a 112-item survey that was mailed to a randomly selected sample of 1,300 congregational clergy drawn from those three groups. Survey results from the Lutheran pastors will also be reported and assessed. The results of the literature review and empirical study demonstrate that Lutheran clergy need to take the duty to be competent in their calling seriously by seeking appropriate clergy-specific education in reproductive counseling. © The Author 2015.

Pickart M.A.,Concordia University at Wisconsin | Klee E.W.,Rochester College
Translational Research | Year: 2014

During the past few decades, zebrafish (Danio rerio) have been a workhorse for developmental biology and genetics. Concurrently, zebrafish have proved highly accessible and effective for translational research by providing a vertebrate animal model useful for gene discovery, disease modeling, chemical genetic screening, and other medically relevant studies. Key resources such as an annotated and complete genome sequence, and diverse tools for genetic manipulation continue to spur broad use of zebrafish. Thus, the purpose of this introductory review is to provide a window into the unique characteristics and diverse uses of zebrafish and to highlight in particular the increasing relevance of zebrafish as a translational animal model. This is accomplished by reviewing broad considerations of anatomic and physiological conservation, approaches for disease modeling and creation, general laboratory methods, genetic tools, genome conservation, and diverse opportunities for functional validation. Additional commentary throughout the review also guides the reader to the 4 new reviews found elsewhere in this special issue that showcase the many unique ways the zebrafish is improving understanding of renal regeneration, mitochondrial disease, dyslipidemia, and aging, for example. With many other possible approaches and a rapidly increasing number of medically relevant reports, zebrafish approaches enhance significantly the tools available for translational research and are actively improving the understanding of human disease. © 2014 Mosby, Inc. All rights reserved.

Chauhan A.S.,Concordia University at Wisconsin
Annals of the New York Academy of Sciences | Year: 2015

In spite of its wide and beneficial pharmacological potential, resveratrol lags behind other compounds because of its comparatively less impressive pharmacokinetic profile. Resveratrol has very low oral bioavailability and, from a formulation perspective, it has low solubility in water, which leads to its poor absorption upon oral administration. Apart from low aqueous solubility, resveratrol has poor metabolic stability and instability at high pH, and is photosensitive. The pharmacokinetic and formulation-related limitations of resveratrol can be controlled by entrapping the small resveratrol molecule inside highly water-soluble poly(amidoamine) dendrimer nanostructures, which provide spherical architecture and polyvalency at the nanoscale level, thus leading to novel features. Dendrimer architecture is used to entrap resveratrol for enhancement of its solubility and stability in aqueous solution; they can be engineered to control pharmacokinetics and targeting for oral, mucosal, transdermal, or parenteral administration. Dendrimers have the potential to work as excipients with multifunctional capability by enhancing solubility, dissolution, stability, permeability, multiple drug/cosmetic entrapment, controlled delivery, bioavailability, and efficacy of drugs. © 2015 New York Academy of Sciences.

Marquette University and Concordia University at Wisconsin | Date: 2016-05-23

Disclosed are substituted (4-hydroxylphenyl)cycloalkane compounds and there use as selective agonists of the estrogen receptor beta isoform (ER). The disclosed compounds may be formulated as pharmaceutical compositions and administered to treat diseases associated with ER activity, such as proliferative diseases and disorders and/or psychiatric diseases or disorders.

Novak C.B.,University of Toronto | von der Heyde R.L.,Concordia University at Wisconsin
Hand Clinics | Year: 2013

Following upper extremity peripheral nerve injury and surgery, rehabilitation is essential to optimize sensorimotor function and outcome. This review presents the evidence and related literature regarding a few key topics related to rehabilitation following peripheral nerve injury and surgery. © 2013 Elsevier Inc.

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