Napier, New Zealand
Napier, New Zealand

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Patent
Comvita New Zealand Ltd. | Date: 2016-07-22

Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.


Steinhorn G.,Comvita New Zealand Ltd | Sims I.M.,Industrial Research Ltd. | Carnachan S.M.,Industrial Research Ltd. | Carr A.J.,Massey University | Schlothauer R.,Comvita New Zealand Ltd
Food Chemistry | Year: 2011

Fractionation of manuka, kanuka and clover honeys indicated the >10 kDa fraction contained small amounts of type II arabinogalactans (AGs), which are often present as arabinogalactan proteins (AGPs). AGPs were isolated from the >10 kDa fraction of kanuka honey using β-glucosyl Yariv reagent and their composition and structure analysed. Constituent sugar, glycosyl linkage and NMR spectroscopy analysis of the purified AGP fraction revealed a predominance of neutral sugars, mainly galactose and arabinose, linked in a highly-branched structure typical of type II AGs. The molecular weight of the major component of the purified AGPs was ∼110 kDa, as determined by size-exclusion chromatography-multi-angle laser light scattering (SEC-MALLS). The Yariv supernatant fraction contained less total sugar, especially galactose, and more protein than purified AGPs. Linkage analysis indicated this fraction also contained an AG-type polymer in addition to various other polysaccharides and SEC-MALLS indicated the molecular weight of the major component was ∼32 kDa. © 2011 Elsevier Ltd. All rights reserved.


Ferguson L.R.,University of Auckland | Schlothauer R.C.,Comvita New Zealand Ltd
Molecular Nutrition and Food Research | Year: 2012

Nutritional genomics reflects gene/nutrient interactions, utilising high-throughput genomic tools in nutrition research. The field also considers the contribution of individual genotypes to wellness and the risk of chronic disease (nutrigenetics), and how such genetic predisposition may be modified by appropriate diets. For example, high consumption of brassicaceous vegetables, including broccoli, has regularly associated with low cancer risk. Bioactive chemicals in broccoli include glucosinolates, plant pigments including kaempferol, quercetin, lutein and carotenoids, various vitamins, minerals and amino acids. Cancer prevention is hypothesised to act through various mechanisms including modulation of xenobiotic metabolising enzymes, NF-E2 p45-related factor-2 (Nrf2)-mediated stress-response mechanisms, and protection against genomic instability. Broccoli and broccoli extracts also regulate the progression of cancer through anti-inflammatory effects, effects on signal transduction, epigenetic effects and modulation of the colonic microflora. Human intervention studies with broccoli and related foods, using standard biomarker methodologies, reveal part of a complex picture. Nutrigenomic approaches, especially transcriptomics, enable simultaneous study of various signalling pathways and networks. Phenotypic, genetic and/or metabolic stratification may identify individuals most likely to respond positively to foods or diets. Jointly, these technologies can provide proof of human efficacy, and may be essential to ensure effective market transfer and uptake of broccoli and related foods. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Patent
COMVITA NEW ZEALAND Ltd | Date: 2011-08-29

Compositions are described with an unexpectedly greater yeast growth inhibitory effect than the individual components alone. The compositions include a mixture of honey, a honey analogue or a honey fraction along with lactoferrin protein. The combination has a synergistic effect in inhibiting yeast growth.


Methods and apparatus are described for the measurement of honey plant origin characteristics via fluorescence.


Patent
COMVITA NEW ZEALAND Ltd | Date: 2011-05-05

Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.


Patent
Comvita New Zealand Ltd | Date: 2011-04-07

A honey based composition is described. The composition includes a mixture of honey, a short chain fatty alcohol and a fatty ester or wax. The composition has applications for use in wound dressings and in one embodiment may be a gel. The composition has a higher than expected storage stability, remaining stable for many weeks when held at elevated temperatures and retains all of the other desirable characteristics including anti-microbial activity.


Patent
Comvita New Zealand Ltd. | Date: 2013-11-12

Immunostimulatory compositions and methods of use are described to either enhance or diminish the immune stimulation effects of a honey or honey isolate by recognition of the presence of type II arabinogalactan compounds and utilising this knowledge to tailor the concentration of such compounds thereby adjusting the immune stimulation effects.


Patent
Comvita New Zealand Ltd | Date: 2015-11-16

A honey based composition is described. The composition includes a mixture of honey, a short chain fatty alcohol and a fatty ester or wax. The composition has applications for use in wound dressings and in one embodiment may be a gel. The composition has a higher than expected storage stability, remaining stable for many weeks when held at elevated temperatures and retains all of the other desirable characteristics including anti-microbial activity.


Trademark
Comvita New Zealand Ltd | Date: 2010-01-26

Shampoo and conditioners; cosmetics, skin cleaning and skin moisturizing preparations, namely, skin cleansers, skin clarifiers, skin lotions, skin moisturizer, skin moisturizer masks; soaps; essential oils for personal use; dentifrices, mouthwashes, lip balms; shampoo and conditioners, cosmetics, skin cleaning and skin moisturizing preparations, namely, skin cleansers, skin clarifiers, skin lotions, skin moisturizer, skin moisturizer masks, soaps, essential oils for personal use, dentifrices, mouthwashes, and lip balms, all containing honey and/or bee products, namely, processed bee pollen, propolis, honey, royal jelly and bee venom. Vitamin and mineral supplements and preparations thereof, namely, powdered nutritional supplement drink mix, tablet, capsule, lozenge, candy, syrup; dietetic substances adapted for medical use with ingredients of processed bee pollen, propolis, honey, royal jelly and/or bee venom, namely, digestives, tablets, capsules, lozenges, syrups, drinks and drink mixes for use as dietary supplements; medicated dentifrices and mouthwashes, throat sprays and lozenges, pharmaceutical preparations, namely, mineral based, marine based namely, seaweed, crustacea, fish oil, fish paste, small invertebrates, shellfish and/or algae based, natural protein based, natural dairy based and botanical based preparations for relief of the symptoms of common cold and influenza; preparations for treating colds and flu in tablet, liquid or syrup form; medicated lip balms, propolis, herbal tinctures, skin care, namely, medicated skin care preparations, woundcare, namely, pharmaceutical and sanitary preparations for wounds; bandages, for dressings, medical plasters and materials for dressing wounds; bandages for wounds incorporating topical preparations containing honey and lip balm ointments, namely, medicinal propolis tinctures, medicated skin care preparation ointments and pharmaceutical preparations for wounds in ointment form; propolis for medicinal or therapeutic purposes. Bee propolis for human consumption, honey, royal jelly for food purposes; non-medicated lozenges; sauce.

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