Complutense University of Madrid

www.ucm.es
Madrid, Spain

The Complutense University of Madrid is a public research university located in Madrid, and one of the oldest universities in the world. The university enrolls over 86,000 students, and consistently ranks as the top university in Spain. It is located on a sprawling campus that occupies the entirety of the Ciudad Universitaria district of Madrid, with annexes in the district of Somosaguas in the neighboring city of Pozuelo de Alarcón.In the course of over seven centuries, the University of Madrid has provided invaluable contributions in the science, fine arts, and political leadership. Alumni include renowned philosophers , writers , scientists , historians , military leaders , foreign leaders , and Prime Minister of Spain for Queen Isabella II Luis González Bravo. In the year 1785, the University of Madrid became one of the first Universities in the world to grant a Doctorate degree to a female student. By Royal Decree of 1857, the University of Madrid was the only institution in Spain authorized to grant doctorates throughout the Spanish Empire.In recent years, the roster of alumni comprises winners of the Nobel Prize , Prince of Asturias Awards , Miguel de Cervantes Prize , as well as European Commissioners, Presidents of the EU Parliament, European Council Secretary General, ECB Executive Board members, NATO Secretary General, UNESCO Director General, IMF Managing Director, and Heads of State. According to the Spanish newspaper El Mundo, the university is widely regarded as the most prestigious academic institution in Spain. Wikipedia.

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The composite material comprises nitrate and chloride anion inorganic salts which may also comprise sulphates, carbonates and/or nitrites and organic and inorganic nanoparticles, such as graphene, and cations of the alkaline, earth-alkaline, earth, carbon and/or amphigenic chemical groups. Said formulations have chemical and physical characteristics, such as the heat capacity, thermal stability and thermal conductivity thereof which make them optimum for being used as an alternative to the commercially available binary mixture in concentrating solar power plants.


Patent
CSIC - Institute of Refrigeration and Complutense University of Madrid | Date: 2017-03-01

The invention relates to a novel implant based on titanium, consisting of a titanium coating formed over biomaterials, applicable in bone implantology. The nanotopographical characteristics of said implants inhibit bacterial adhesion and formation of bacterial biofilm on the surface, the implants simultaneously exhibiting suitable properties for the adhesion, extension, and proliferation of the bone-forming cells. The invention also relates to a method for producing the implant by means of oblique incidence techniques and to the use thereof in bone implantology..


The present invention relates to a prognosis method for determining the severity of autoimmune diseases, for example, rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus, characterized in that it comprises detecting certain genetic polymorphisms of the VIP gene including, among others, rs35643203, rs71575932 and/or rs7755568. The method of the invention is also useful for establishing a customized patient treatment. The invention also relates to the use of the genetic polymorphisms of the VIP gene described in the invention as biomarkers of said diseases, as well as to a kit comprising primers or probes for detecting said polymorphisms and to the use thereof for the same purpose.


Patent
Complutense University of Madrid | Date: 2017-02-01

DIOPTER FOR BLOCKING RADIATIONS WITH SHORT AND MEDIUM WAVELENGTHS FROM VISIBLE SPECTRUM THAT AFFECT HUMAN PHYSIOLOGY comprising the selective absorption of short wavelengths comprised between 380 nm and 500 nm between a maximum threshold and minimum threshold of absorption; and selective absorption of medium wavelengths comprised between 500 nm and 590 nm between a maximum threshold and minimum threshold of absorption; and wherein the selective absorption of short and medium wavelengths comprised between 380-590 nm does not completely block the passage of visible light within said range. Other embodiments include an LED display, a software product and an electronic device and ophthalmic, intraocular, or solar lenses.


Method and electronic device for detecting the level of light emission that a light source emits into a users ocular system; measuring the users level of aversion to the amount of light received in his/her ocular system through analysis of his/her eye reaction; and comparing the level of aversion to the amount of light received by his/her ocular system measured in step (b) to the level of aversion acceptable for that user and stored in a memory (102) of an electronic device (100).


Patent
Instituto Madrileno Of Estudio Avanzados Nanocienca Imdea Nanocencia and Complutense University of Madrid | Date: 2017-06-14

The present invention relates to an optoelectronic and/or photoelectrochemical device comprising at least one organic-inorganic perovskite as sensitizer and at least one compound of formula (I)


Patent
Complutense University of Madrid | Date: 2015-04-13

The composite material comprises nitrate and chloride anion inorganic salts which may also comprise sulphates, carbonates and/or nitrites and organic and inorganic nanoparticles, such as graphene, and cations of the alkaline, earth-alkaline, earth, carbon and/or amphigenic chemical groups. Said formulations have chemical and physical characteristics, such as the heat capacity, thermal stability and thermal conductivity thereof which make them optimum for being used as an alternative to the commercially available binary mixture in concentrating solar power plants.


Gonzalez-Vera J.A.,Complutense University of Madrid
Chemical Society Reviews | Year: 2012

Protein phosphorylation is the most frequent post-translational modification used to regulate protein activity. Protein kinases, the enzymes that catalyze the phosphoryl transfer, are implicated in practically every aspect of normal as well as abnormal cell functions. Consequently, sensitive, selective, high-throughput and widely applicable methods for monitoring protein kinase activity will provide valuable tools to screen inhibitor candidates for therapeutics and chemical biology, and to unravel the diverse signaling cascades in which these enzymes are pivotal. Peptide-based chemosensors that rely on fluorescence changes upon phosphorylation are highly desirable, because these systems allow a continuous readout offering an excellent spatial and temporal resolution to observe in real time the kinase activity. This tutorial review briefly summarizes the different fluorescent continuous peptide-based strategies that are being commonly employed to sense protein phosphorylation, introduces a few novel and attractive emerging assays, discusses their advantages and limitations, and highlights possible future directions. © 2012 The Royal Society of Chemistry.


MacIa E.,Complutense University of Madrid
Reports on Progress in Physics | Year: 2012

In this work we consider the role of aperiodic order - order without periodicity - in the design of different optical devices in one, two and three dimensions. To this end, we will first study devices based on aperiodic multilayered structures. In many instances the recourse to Fibonacci, Thue-Morse or fractal arrangements of layers results in improved optical properties compared with their periodic counterparts. On this basis, the possibility of constructing optical devices based on a modular design of the multilayered structure, where periodic and quasiperiodic subunits are properly mixed, is analyzed, illustrating how this additional degree of freedom enhances the optical performance in some specific applications. This line of thought can be naturally extended to aperiodic arrangements of optical elements, such as nanospheres or dielectric rods in the plane, as well as to three-dimensional photonic quasicrystals based on polymer materials. In this way, plentiful possibilities for new tailored materials naturally appear, generally following suitable optimization algorithms. Then, we present a detailed discussion on the physical properties supporting the preferential use of aperiodic devices in a number of optical applications, opening new avenues for technological innovation. Finally we suggest some related emerging topics that deserve some attention in the years to come. © 2012 IOP Publishing Ltd.


Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: SC1-PM-09-2016 | Award Amount: 6.75M | Year: 2017

The main goal of HIVACAR proposal is to change the current paradigm of HIV treatment by obtaining a functional cure for HIV (i.e., control of viral load to levels below the threshold of 50 copies/ml and maintenance of high CD4\ T-cell count after discontinuation of antiretroviral therapy) thanks to effectively targeting residual virus replication and viral reservoirs. In order to do so, the planned novel strategy is to successfully combine immune-based therapies, including therapeutic vaccines and broadly neutralizing antibodies with latency reversing agents, in a proof-of-concept phase IIa clinical trial. HIVACAR project will lead to a reduction of the actual costs related to HIV treatment and management and of the social public health as well as an improvement in the patients quality of life. HIVACAR project has been conceived under the framework of responsible research and innovation, so patients and other stakeholders will have a key role from the inception of the project until obtaining the results. Patients will be perfectly aware of how this therapy has been conceived and the real impact and change in their actual quality of life, as well as how the clinical trial has been designed and the consequences of participating in it. In addition, patients (and the general population) will tailor the project and its results dissemination and communication. This patient engagement will not be limited to the clinical trial but also to the rest of the activities of the project, so patients and the general society will be aware of how the research is developed and can include the patients point of view in the research activities. In addition, the socio-economic and psycho-social impact of the new treatment will be also analysed so overwhelming data on the benefits and impact of the new treatment will be obtained and shown to all the stakeholders.

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