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Aymerich M.,University of Santiago de Compostela | Nieto D.,University of Santiago de Compostela | alvarez E.,Complexo Hospitalario Universitario Of Santiago Of Compostela Chus Sergas | Flores-Arias M.T.,University of Santiago de Compostela
Materials | Year: 2017

A laser based technique for microstructuring titanium and tantalum substrates using the Talbot effect and an array of microlenses is presented. By using this hybrid technique; we are able to generate different patterns and geometries on the top surfaces of the biomaterials. The Talbot effect allows us to rapidly make microstructuring, solving the common problems of using microlenses for multipatterning; where the material expelled during the ablation of biomaterials damages the microlens. The Talbot effect permits us to increase the working distance and reduce the period of the patterns. We also demonstrate that the geometries and patterns act as anchor points for cells; affecting the cell adhesion to the metallic substrates and guiding how they spread over the material. © 2017 by the authors.


Monteagudo B.,Hospital Arquitecto Marcide Area Sanitaria Of Ferrol Sergas | Labandeira J.,Hospital Arquitecto Marcide Area Sanitaria Of Ferrol Sergas | Leon-Muinos E.,Complexo Hospitalario Universitario Of Santiago Of Compostela Chus Sergas | Romaris R.,Complexo Hospitalario Universitario Of Santiago Of Compostela Chus Sergas | And 4 more authors.
Medicina Cutanea Ibero-Latino-Americana | Year: 2013

We performed a prospective study of 1,000 neonates investigated in the first 72 hours of life in the Health Area of Ferrol (northwest of Spain), in order to assess the prevalence of hyperpigmentation of the genital area, the influence of different maternal and neonatal parameters, day of neonatal exploration and type of delivery. Overall frequency of hyperpigmentation was 15.3%. We found a higher prevalence of this dermatosis in non-Caucasian infants (p = 0.000) of male sex (p = 0.000), with Mongolian spot (p = 0.000), vaginal delivery (p = 0.030), maternal age below 30 years (p = 0.006) and at least two previous pregnancies (p = 0.015).


Aymerich M.,University of Santiago de Compostela | Gomez-Varela A.I.,University of Santiago de Compostela | Alvarez E.,Complexo Hospitalario Universitario Of Santiago Of Compostela Chus Sergas | Flores-Arias M.T.,University of Santiago de Compostela
Materials | Year: 2016

A study of PDMS (polydimethylsiloxane) sol-gel-coated channels fabricated using soft lithography and a laser direct writing technique is presented. PDMS is a biocompatible material that presents a high versatility to reproduce several structures. It is widely employed in the fabrication of preclinical devices due to its advantages but it presents a rapid chemical deterioration to organic solvents. The use of sol-gel layers to cover the PDMS overcomes this problem since it provides the robustness of glass for the structures made with PDMS, decreasing its deterioration and changing the biocompatibility of the surface. In this work, PDMS channels are coated with three different kinds of sol-gel compositions (60MTES/40TEOS, 70MTES/30TISP and 80MTES/20TISP). The endothelial cell adhesion to the different coated devices is evaluated in order to determine the most suitable sol-gel preparation conditions to enhance cellular adhesion. © 2016 by the authors.

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