Complejo Hospitalario Universitario Of Santiago Of Compostela Chus

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Complejo Hospitalario Universitario Of Santiago Of Compostela Chus

Spain

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Martinez-Urtaza J.,University of Santiago de Compostela | Blanco-Abad V.,University of Santiago de Compostela | Rodriguez-Castro A.,University of Santiago de Compostela | Ansede-Bermejo J.,University of Santiago de Compostela | And 3 more authors.
ISME Journal | Year: 2012

The life cycle of Vibrio parahaemolyticus has been conventionally associated with estuarine areas characterized by moderate salinity and warm seawater temperatures. Recent evidence suggests that the distribution and population dynamics of V. parahaemolyticus may be shaped by the existence of an oceanic transport of communities of this organism mediated by zooplankton. To evaluate this possibility, the presence of V. parahaemolyticus in the water column of offshore areas of Galicia was investigated by PCR monthly over an 18-month period. Analysis of zooplankton and seawater showed that the occurrence of V. parahaemolyticus in offshore areas was almost exclusively associated with zooplankton and was present in 80% of the samples. The influence of environmental factors assessed by generalized additive models revealed that the abundance and seasonality of V. parahaemolyticus in zooplankton was favoured by the concurrence of downwelling periods that promoted the zooplankton patchiness. These results confirm that offshore waters may be common habitats for V. parahaemolyticus, including strains with virulent traits. Additionally, genetically related populations were found in offshore zooplankton and in estuaries dispersed along 1500 km. This finding suggests that zooplankton may operate as a vehicle for oceanic dispersal of V. parahaemolyticus populations, connecting distant regions and habitats, and thereby producing impacts on the local community demography and the spread of Vibrio-related diseases. © 2012 International Society for Microbial Ecology All rights reserved.


Gayoso-Garcia S.,Complejo Hospitalario Universitario runa | Villa-Fernandez J.M.,Complejo Hospitalario Universitario runa | Castro-Castro J.,Complejo Hospitalario Universitario Of Ourense Chuo | Albertos-Castro J.M.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Revista Espanola de Cirugia Oral y Maxilofacial | Year: 2016

Pneumosinus dilatans (PD) is a rare condition in adults and truly exceptional in children. There are approximately 100 reported cases in adults, with fewer than 10 in adolescents aged 12-16, and none in children. It is described as a benign airfilled expansion of a paranasal sinus beyond the normal osseous boundaries. It could result in cosmetic and functional complications. The precise etiology of the condition remains unknown. The frontal sinus is the most commonly affected. It is reported the case of a 9-year-old female diagnosed with PD frontalis at 3 years of age. She underwent surgery for significant cosmetic alterations. The surgical plan included an intracranial approach through coronal incision with excellent cosmetic results. © 2014 SECOM


Taboada Suarez A.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus | Prieto A.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus | Couto I.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus | Brea B.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus | Gonzalez E.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Neurocirugia | Year: 2010

Basal cell carcinoma is the most frequent skin malignant neoplasm, although it doesn't usually compromise a vital risk. However, there are cases in which their local aggressiveness is very important, and it get deep structures. We present a 62 years old female operated several times because multifocal basal cell carcinoma on her scalp. She consulted with a wide local recidive affecting dura mater and superior sagittal sinus. We show the clinical case and the surgical treatment employed realized by Plastic and Neurosurgery Departments.


Lopez-Raton M.,University of Santiago de Compostela | Rodriguez-Alvarez M.X.,University of Vigo | Cadarso-Suarez C.,University of Santiago de Compostela | Gude-Sampedro F.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Journal of Statistical Software | Year: 2014

Continuous diagnostic tests are often used for discriminating between healthy and diseased populations. For the clinical application of such tests, it is useful to select a cutpoint or discrimination value c that deffnes positive and negative test results. In general, individuals with a diagnostic test value of c or higher are classiffed as diseased. Several search strategies have been proposed for choosing optimal cutpoints in diagnostic tests, depending on the underlying reason for this choice. This paper introduces an R package, known as OptimalCutpoints, for selecting optimal cutpoints in diagnostic tests. It incorporates criteria that take the costs of the different diagnostic decisions into account, as well as the prevalence of the target disease and several methods based on measures of diagnostic test accuracy. Moreover, it enables optimal levels to be calculated according to levels of given (categorical) covariates. While the numerical output includes the optimal cutpoint values and associated accuracy measures with their conffdence intervals, the graphical output includes the receiver operating characteristic (ROC) and predictive ROC curves. An illustration of the use of OptimalCutpoints is provided, using a real biomedical dataset. © 2014 American Statistical Association. All rights reserved.


Gayoso-Garcia S.,Complejo Hospitalario Universitario runa | Villa-Fernandez J.M.,Complejo Hospitalario Universitario runa | Castro-Castro J.,Complejo Hospitalario Universitario Of Ourense Chuo | Albertos-Castro J.M.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Revista Espanola de Cirugia Oral y Maxilofacial | Year: 2015

Pneumosinus dilatans (PD) is a rare condition in adults and truly exceptional in children. There are approximately 100 reported cases in adults, with fewer than 10 in adolescents aged 12-16, and none in children. It is described as a benign airfilled expansion of a paranasal sinus beyond the normal osseous boundaries. It could result in cosmetic and functional complications. The precise etiology of the condition remains unknown. The frontal sinus is the most commonly affected. It is reported the case of a 9-year-old female diagnosed with PD frontalis at 3 years of age. She underwent surgery for significant cosmetic alterations. The surgical plan included an intracranial approach through coronal incision with excellent cosmetic results. © 2014 SECOM.


Cortes J.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Clinical nuclear medicine | Year: 2014

A 48-year-old-woman suffering from recurrent left hemipalsy was referred to the hospital. MRI showed hyperintense lesions in periventricular white matter. Cerebral angiography revealed stenosis in the bilateral internal carotid and hypertrophic collateral vessels at the brain base, compatible with moyamoya syndrome. A visual comparison between perfusion SPECT with and without acetazolamide is employed in evaluation of these patients. Nevertheless, this traditional evaluation has some drawbacks associated with the variability between the 2 SPECT images and the lack of anatomical information. We propose a quantitative method based on the realigment, normalization, substraction, and co-registration of the 2 perfusion SPECT with MRI.


PubMed | Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Type: Case Reports | Journal: Clinical nuclear medicine | Year: 2014

A 48-year-old-woman suffering from recurrent left hemipalsy was referred to the hospital. MRI showed hyperintense lesions in periventricular white matter. Cerebral angiography revealed stenosis in the bilateral internal carotid and hypertrophic collateral vessels at the brain base, compatible with moyamoya syndrome. A visual comparison between perfusion SPECT with and without acetazolamide is employed in evaluation of these patients. Nevertheless, this traditional evaluation has some drawbacks associated with the variability between the 2 SPECT images and the lack of anatomical information. We propose a quantitative method based on the realigment, normalization, substraction, and co-registration of the 2 perfusion SPECT with MRI.


PubMed | Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Type: | Journal: European journal of pharmacology | Year: 2015

Lysophosphatidic acid (LPA) is a phospholipid that is mainly produced by the hydrolysis of lysophosphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX). LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation, differentiation and motility. LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX-LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis. This review summarises the current literature of the ATX-LPA pathway in rheumatoid arthritis.


PubMed | Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Type: Journal Article | Journal: International psychogeriatrics | Year: 2012

The use of telemedicine for the care of mental health problems has developed significantly over the last decade thanks to the emergence of a number of stable telepsychiatry programs in many countries. Parallel to this development, this care modality has also targeted specific populations with higher difficulty in gaining access to mental health services such as the elderly. Telepsychogeriatrics is expected to have an increasing role in providing care to geographically isolated rural communities, with a particular focus on long-term care facilities, in light of the high prevalence of psychiatric disorders in these centers and the lack of available specialized care.A thorough search of the literature was conducted using Medline, Web of Science, and PsychINFO databases in order to gather available evidence on the applicability of telepsychiatry, specifically the use of videoconferencing for remote consultation, in the elderly population with mental disorders. A succinct description of the selected studies is given along with a general reflection on the state-of-the-art in the field of psychogeriatric clinical practice and research.Research on the use of telemedicine in this age group has taken into account their special characteristics, and has focused on demonstrating its applicability, the acceptance and satisfaction of elderly users and their healthcare providers, the possibility of carrying out cognitive and diagnostic assessments, and the efficiency of these programs.Despite limited experience, telepsychogeriatrics appears to be a viable option, well accepted by patients, including those having dementia. More systematized studies are needed in this new field based on larger sample sizes, including comparison with traditional consultations and assessment of the clinical outcomes.


PubMed | Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Type: Journal Article | Journal: PloS one | Year: 2012

The quest for therapeutic applications of obestatin involves, as a first step, the determination of its 3D solution structure and the relationship between this structure and the biological activity of obestatin. On this basis, we have employed a combination of circular dichroism (CD), nuclear magnetic resonance (NMR) spectroscopy, and modeling techniques to determine the solution structure of human obestatin (1). Other analogues, including human non-amidated obestatin (2) and the fragment peptides (6-23)-obestatin (3), (11-23)-obestatin (4), and (16-23)-obestatin (5) have also been scrutinized. These studies have been performed in a micellar environment to mimic the cell membrane (sodium dodecyl sulfate, SDS). Furthermore, structural-activity relationship studies have been performed by assessing the in vitro proliferative capabilities of these peptides in the human retinal pigmented epithelial cell line ARPE-19 (ERK1/2 and Akt phosphorylation, Ki67 expression, and cellular proliferation). Our findings emphasize the importance of both the primary structure (composition and size) and particular segments of the obestatin molecule that posses significant -helical characteristics. Additionally, details of a species-specific role for obestatin have also been hypothesized by comparing human and mouse obestatins (1 and 6, respectively) at both the structural and bioactivity levels.

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