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Lopez-Raton M.,University of Santiago de Compostela | Rodriguez-Alvarez M.X.,University of Vigo | Cadarso-Suarez C.,University of Santiago de Compostela | Gude-Sampedro F.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Journal of Statistical Software | Year: 2014

Continuous diagnostic tests are often used for discriminating between healthy and diseased populations. For the clinical application of such tests, it is useful to select a cutpoint or discrimination value c that deffnes positive and negative test results. In general, individuals with a diagnostic test value of c or higher are classiffed as diseased. Several search strategies have been proposed for choosing optimal cutpoints in diagnostic tests, depending on the underlying reason for this choice. This paper introduces an R package, known as OptimalCutpoints, for selecting optimal cutpoints in diagnostic tests. It incorporates criteria that take the costs of the different diagnostic decisions into account, as well as the prevalence of the target disease and several methods based on measures of diagnostic test accuracy. Moreover, it enables optimal levels to be calculated according to levels of given (categorical) covariates. While the numerical output includes the optimal cutpoint values and associated accuracy measures with their conffdence intervals, the graphical output includes the receiver operating characteristic (ROC) and predictive ROC curves. An illustration of the use of OptimalCutpoints is provided, using a real biomedical dataset. © 2014 American Statistical Association. All rights reserved. Source


Martinez-Urtaza J.,University of Santiago de Compostela | Blanco-Abad V.,University of Santiago de Compostela | Rodriguez-Castro A.,University of Santiago de Compostela | Ansede-Bermejo J.,University of Santiago de Compostela | And 3 more authors.
ISME Journal | Year: 2012

The life cycle of Vibrio parahaemolyticus has been conventionally associated with estuarine areas characterized by moderate salinity and warm seawater temperatures. Recent evidence suggests that the distribution and population dynamics of V. parahaemolyticus may be shaped by the existence of an oceanic transport of communities of this organism mediated by zooplankton. To evaluate this possibility, the presence of V. parahaemolyticus in the water column of offshore areas of Galicia was investigated by PCR monthly over an 18-month period. Analysis of zooplankton and seawater showed that the occurrence of V. parahaemolyticus in offshore areas was almost exclusively associated with zooplankton and was present in 80% of the samples. The influence of environmental factors assessed by generalized additive models revealed that the abundance and seasonality of V. parahaemolyticus in zooplankton was favoured by the concurrence of downwelling periods that promoted the zooplankton patchiness. These results confirm that offshore waters may be common habitats for V. parahaemolyticus, including strains with virulent traits. Additionally, genetically related populations were found in offshore zooplankton and in estuaries dispersed along 1500 km. This finding suggests that zooplankton may operate as a vehicle for oceanic dispersal of V. parahaemolyticus populations, connecting distant regions and habitats, and thereby producing impacts on the local community demography and the spread of Vibrio-related diseases. © 2012 International Society for Microbial Ecology All rights reserved. Source


Gayoso-Garcia S.,Complejo Hospitalario Universitario runa | Villa-Fernandez J.M.,Complejo Hospitalario Universitario runa | Castro-Castro J.,Complejo Hospitalario Universitario Of Ourense Chuo | Albertos-Castro J.M.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Revista Espanola de Cirugia Oral y Maxilofacial | Year: 2015

Pneumosinus dilatans (PD) is a rare condition in adults and truly exceptional in children. There are approximately 100 reported cases in adults, with fewer than 10 in adolescents aged 12-16, and none in children. It is described as a benign airfilled expansion of a paranasal sinus beyond the normal osseous boundaries. It could result in cosmetic and functional complications. The precise etiology of the condition remains unknown. The frontal sinus is the most commonly affected. It is reported the case of a 9-year-old female diagnosed with PD frontalis at 3 years of age. She underwent surgery for significant cosmetic alterations. The surgical plan included an intracranial approach through coronal incision with excellent cosmetic results. © 2014 SECOM. Source


Cortes J.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus
Clinical nuclear medicine | Year: 2014

A 48-year-old-woman suffering from recurrent left hemipalsy was referred to the hospital. MRI showed hyperintense lesions in periventricular white matter. Cerebral angiography revealed stenosis in the bilateral internal carotid and hypertrophic collateral vessels at the brain base, compatible with moyamoya syndrome. A visual comparison between perfusion SPECT with and without acetazolamide is employed in evaluation of these patients. Nevertheless, this traditional evaluation has some drawbacks associated with the variability between the 2 SPECT images and the lack of anatomical information. We propose a quantitative method based on the realigment, normalization, substraction, and co-registration of the 2 perfusion SPECT with MRI. Source


Alen B.O.,Complejo Hospitalario Universitario Of Santiago Of Compostela Chus | Alen B.O.,CIBER ISCIII | Alen B.O.,University of Santiago de Compostela | Nieto L.,CSIC - Biological Research Center | And 25 more authors.
PLoS ONE | Year: 2012

The quest for therapeutic applications of obestatin involves, as a first step, the determination of its 3D solution structure and the relationship between this structure and the biological activity of obestatin. On this basis, we have employed a combination of circular dichroism (CD), nuclear magnetic resonance (NMR) spectroscopy, and modeling techniques to determine the solution structure of human obestatin (1). Other analogues, including human non-amidated obestatin (2) and the fragment peptides (6-23)-obestatin (3), (11-23)-obestatin (4), and (16-23)-obestatin (5) have also been scrutinized. These studies have been performed in a micellar environment to mimic the cell membrane (sodium dodecyl sulfate, SDS). Furthermore, structural-activity relationship studies have been performed by assessing the in vitro proliferative capabilities of these peptides in the human retinal pigmented epithelial cell line ARPE-19 (ERK1/2 and Akt phosphorylation, Ki67 expression, and cellular proliferation). Our findings emphasize the importance of both the primary structure (composition and size) and particular segments of the obestatin molecule that posses significant α-helical characteristics. Additionally, details of a species-specific role for obestatin have also been hypothesized by comparing human and mouse obestatins (1 and 6, respectively) at both the structural and bioactivity levels. © 2012 Alén et al. Source

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