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Belinchon A.,Complejo Hospitalario Universitario Albacete | Perez- Garrigues H.,Hospital Universitario La Paz | Tenias J.M.,Research Support Unit | Lopez A.,University of Castilla - La Mancha
Laryngoscope | Year: 2011

Objectives: To investigate the level of hearing loss and the configuration of the mean audiometric curve over the course of Menière's disease, correcting the data according to patient age. Study Design: A retrospective study of 3,963 hearing tests. Methods: Descriptive, longitudinal study of pure-tone audiometries of 237 patients at a tertiary hospital who had been diagnosed with definitive Menière's disease according to the American Academy of Otorhinolaryngology criteria. All audiometric results were age-corrected, and patients were followed for 1 to 31 years. In patients who had undergone surgery, only the data collected before the operation were assessed. Results: In patients with unilateral disease, the mean hearing loss was characteristically low frequency, even in very advanced stages of the disease. Hearing loss was accentuated at 5 and 15 years from onset. In bilateral cases, hearing loss was slightly more severe and the average loss produced a flatter audiometric curve than in unilateral cases. Conclusions: In Menière's disease, audiometry results corrected for patient age show an inherent upward-sloping configuration of the mean audiometric curve at all time points during the disease. The hearing pattern differs between unilateral and bilateral disease. The audiometric curve configuration may be an indicator of future bilateral disease. © 2011 The American Laryngological, Rhinological, and Otological Society, Inc., Rhinological, and Otological Society, Inc.

Arenas M.,Rovira i Virgili University | Gascon M.,Rovira i Virgili University | Rovirosa T.,Institute Clinic Of Malalties Hematologiques I Oncologiques Icmho | Hernandez V.,Hospital Universitari Sant Joan Of Reus | And 4 more authors.
Reports of Practical Oncology and Radiotherapy | Year: 2015

Aim: To evaluate the effect of lymphadenectomy and/or radiotherapy on recurrence and survival patterns in endometrial carcinoma (EC) in a radiotherapy reference centre population. Material and Methods: A retrospective population-based review was conducted on 261 patients with stages I-III EC. Univariate and multivariate analyses were carried out. Both recurrence and survival were analysed according to patient age, FIGO stage, tumour size, myometrial invasion, tumour grade, lymphadenectomy, external beam irradiation (EBI), and brachytherapy (BT). Results: Median age: 64.8 years. Median follow-up: 151 months. The following treatments were administered: surgery, 97.32%; lymph-node dissection, 54.4%; radiotherapy, 162 patients (62%) (EBI and BT: 64.1%, BT alone: 30.2%, EBI alone: 5.6%).Twenty-six patients (9.96%) suffered loco-regional recurrence, whilst 27 (10.34%) suffered distant failure. The 5-year overall survival (OS) for all stages was 80.1%. The 5-year disease free survival (DFS) was 92.1% for all patients. The 10-year DFS was 89.9%.The independent significant prognostic factors for a good outcome identified through the multivariate analysis were: age <75 years (p=. 0.001); tumour size ≤2. cm (p=. 0.003); myometrial invasion ≤50% (p=. 0.011); lymphadenectomy (p=. 0.02); EBI (p=. 0.001); and BT (p=. 0.031).Toxicity occurred in 114 of the 162 patients who received radiotherapy (70.5%). The toxicity was mainly acute, and late in only 28.3% (n=. 45) of cases. The majority experienced G1-2 toxicity, and only 3% of patients experienced G3 late toxicity (5/162). Conclusions: Our results suggest that age <75 years, tumour size ≤2. cm, myometrial invasion ≤50%, lymphadenectomy, EBI, and BT, are predictors of a good outcome in EC. © 2014 Greater Poland Cancer Centre.

Carrion B.,NanoDrugs S.L. | Perez-Martinez F.C.,NanoDrugs S.L. | Monteagudo S.,NanoDrugs S.L. | Perez-Carrion M.D.,NanoDrugs S.L. | And 4 more authors.
Peritoneal Dialysis International | Year: 2011

Objective: Continuous exposure of the peritoneal membrane to high glucose dialysis solutions can produce functional alterations in this membrane. We studied the toxic effects of high glucose (50 mmol/L and 83 mmol/L) and its reversal by atorvastatin (0.5 - 5 μmol/L) on cultures of rat peritoneal mesothelial cells (PMCs). Methods: Rat PMCs were harvested from the peritonea of male Sprague-Dawley rats and grown in M199 medium supplemented with 10% fetal bovine serum. The effects of high glucose (50 mmol/L and 83 mmol/L) on levels of reactive oxygen species (ROS), on caspase 3 activity, and on phospho-p38 mitogen-activated protein kinase (MAPK) in the cultures were evaluated. Results: Exposure to high glucose (for 4, 8, and 24 hours) increased intracellular levels of ROS and phospho-p38 MAPK (indices of cellular toxicity). Atorvastatin blocked these toxic effects of high glucose, being more effective against 50 mmol/L glucose (protective effects were observed above 0.5 μmol/L) than against 83 mmol/L (protective effects were observed above 2.5 μmol/L). Atorvastatin was also able to prevent glucose-induced increase in caspase 3 activity. Conclusions: The present study shows that high glucose may promote oxidative stress and may activate apoptotic pathways in rat PMCs. These toxic effects could be reversed byatorvastatin. © 2011 International Society for Peritoneal Dialysis.

Arenas M.,Rovira i Virgili University | Sabater S.,Complejo Hospitalario Universitario Albacete | Jimenez P.L.,University of Las Palmas de Gran Canaria | Rovirosa A.,Hospital Universitari Clinic Of Barcelona | And 4 more authors.
Reports of Practical Oncology and Radiotherapy | Year: 2016

Immunomodulatory effects of low-dose radiotherapy (LD-RT) have been used for the treatment of several benign diseases, including arthrodegenerative and inflammatory pathologies. Graves' disease is an autoimmune disease and radiotherapy (RT) is a therapeutic option for ocular complications. The dose recommended in the clinical practice is 20 Gy (2 Gy/day). We hypothesized that lower doses (<10 Gy total dose, <1 Gy/day) could results in higher efficacy if we achieved anti-inflammatory and immunomodulatory effects of LD-RT.We review current evidence on the effects of RT in the treatment of Graves' disease and the possible use of LD-RT treatment strategy. © 2016 Greater Poland Cancer Centre.

Torres Lozano P.,Complejo Hospitalario Universitario Albacete | Gallach Sanchis D.,Complejo Hospitalario Universitario Albacete | Gallach Sanchis D.,University of Castilla - La Mancha | Pardo Coello M.M.,University of Castilla - La Mancha
Revista Espanola de Cirugia Ortopedica y Traumatologia | Year: 2012

A case is presented of a 69 year old male patient with a history of wrist fracture from over 50 years ago with pain refractory to analgesics and with joint destruction of the wrist in conventional radiology. We have conducted a review of extrapulmonary tuberculous osteoarthritis discussing the diagnosis and treatment of this unusual presentation of the disease. © 2011 SECOT.

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