Complejo Hospitalario Universitario Albacete

Spain

Complejo Hospitalario Universitario Albacete

Spain
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Torres Lozano P.,Complejo Hospitalario Universitario Albacete | Gallach Sanchis D.,Complejo Hospitalario Universitario Albacete | Gallach Sanchis D.,University of Castilla - La Mancha | Pardo Coello M.M.,University of Castilla - La Mancha
Revista Espanola de Cirugia Ortopedica y Traumatologia | Year: 2012

A case is presented of a 69 year old male patient with a history of wrist fracture from over 50 years ago with pain refractory to analgesics and with joint destruction of the wrist in conventional radiology. We have conducted a review of extrapulmonary tuberculous osteoarthritis discussing the diagnosis and treatment of this unusual presentation of the disease. © 2011 SECOT.


Garcia-Cano J.,University of Castilla - La Mancha | Ambroise G.,University Paris - Sud | Pascual-Serra R.,University of Castilla - La Mancha | Carrion M.C.,Organica y Bioquimica | And 10 more authors.
Oncotarget | Year: 2015

Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new therapeutic strategies to cisplatin resistance, we evaluated, in a model of lung cancer (H1299 and H460 cell lines), the nature of the pathways leading to cell death. We observed that H1299 displayed a natural resistance to cisplatin due to an inability to trigger an apoptotic response that correlates with the induction of autophagy. However, pharmacological and genetic approaches showed how autophagy was a mechanism associated to cell death rather than to resistance. Indeed, pro-autophagic stimuli such as mTOR or Akt inhibition mediate cell death in both cell lines to a similar extent. We next evaluated the response to a novel platinum compound, monoplatin, able to promote cell death in an exclusive autophagy-dependent manner. In this case, no differences were observed between both cell lines. Furthermore, in response to monoplatin, two molecular hallmarks of cisplatin response (p53 and MAPKs) were not implicated, indicating the ability of this pro-autophagic compound to overcome cisplatin resistance. In summary, our data highlight how induction of autophagy could be used in cisplatin resistant tumours and an alternative treatment for p53 mutated patient in a synthetic lethally approach.


Mercedes L.M.,Complejo Hospitalario Universitario Albacete | Francisco L.M.,Complejo Hospitalario Universitario Albacete | Sotoca Fernandez Jorge V.,Complejo Hospitalario Universitario Albacete
Archivos de Medicina | Year: 2011

Introduction: the retinoschisis is a splitting of the neurosensory retina in to two layers. There are three types of retinoschisis, degenerative peripheral retinoschisis starts at 20 years and is usually asymptomatic and rarely requires treatment. Case report: we present a male patient who is 28 years old, we find an inferior retinoschisis in both eyes near the macular area without affection of this area. The patient was stable and he did not need any intervention. Discussion: the treatment of this disease is controversial, in this case we observed without any intervention because the patient was asymptomatic, had a good visual acuity without evidence of progression and also the location in the posterior pole could complicate any surgery. © Under License of Creative Commons Attribution 3.0 License.


Belinchon A.,Complejo Hospitalario Universitario Albacete | Perez- Garrigues H.,Hospital Universitario La Paz | Tenias J.M.,Hospital la Mancha Centro | Lopez A.,University of Castilla - La Mancha
Laryngoscope | Year: 2011

Objectives: To investigate the level of hearing loss and the configuration of the mean audiometric curve over the course of Menière's disease, correcting the data according to patient age. Study Design: A retrospective study of 3,963 hearing tests. Methods: Descriptive, longitudinal study of pure-tone audiometries of 237 patients at a tertiary hospital who had been diagnosed with definitive Menière's disease according to the American Academy of Otorhinolaryngology criteria. All audiometric results were age-corrected, and patients were followed for 1 to 31 years. In patients who had undergone surgery, only the data collected before the operation were assessed. Results: In patients with unilateral disease, the mean hearing loss was characteristically low frequency, even in very advanced stages of the disease. Hearing loss was accentuated at 5 and 15 years from onset. In bilateral cases, hearing loss was slightly more severe and the average loss produced a flatter audiometric curve than in unilateral cases. Conclusions: In Menière's disease, audiometry results corrected for patient age show an inherent upward-sloping configuration of the mean audiometric curve at all time points during the disease. The hearing pattern differs between unilateral and bilateral disease. The audiometric curve configuration may be an indicator of future bilateral disease. © 2011 The American Laryngological, Rhinological, and Otological Society, Inc., Rhinological, and Otological Society, Inc.


Belinchon A.,Complejo Hospitalario Universitario Albacete | Perez-Garrigues H.,Hospital Universitario La Paz | Tenias J.M.,Hospital la Mancha Centro
Audiology and Neurotology | Year: 2012

Objective: To investigate the sequence and correlation of symptoms of Ménière's disease (MD) depending on their order of manifestation. Methods: Descriptive, longitudinal study of the symptoms in 237 tertiary hospital patients who had been diagnosed with definite MD according to the criteria of the American Academy of Otolaryngology. Patients were followed for 1-31 years. Results: Disease began with the three classic symptoms in only 40% of the patients. We recorded the mean, median and maximum time needed to complete the symptoms as well as the time elapsed in some patients from disease onset in one ear to bilateral involvement. Conclusions: We reckon that this study may be of great help in ruling out a diagnosis of MD when the patient presents with only one or two symptoms of the triad. Furthermore, regarding the planning of treatment, the time interval between unilateral and bilateral involvement (5-7 years) is very important since bilateral involvement has great repercussions on treatment, especially surgical treatment. © 2011 S. Karger AG, Basel.


Carrion B.,NanoDrugs SL | Perez-Martinez F.C.,NanoDrugs SL | Monteagudo S.,NanoDrugs SL | Perez-Carrion M.D.,NanoDrugs SL | And 4 more authors.
Peritoneal Dialysis International | Year: 2011

Objective: Continuous exposure of the peritoneal membrane to high glucose dialysis solutions can produce functional alterations in this membrane. We studied the toxic effects of high glucose (50 mmol/L and 83 mmol/L) and its reversal by atorvastatin (0.5 - 5 μmol/L) on cultures of rat peritoneal mesothelial cells (PMCs). Methods: Rat PMCs were harvested from the peritonea of male Sprague-Dawley rats and grown in M199 medium supplemented with 10% fetal bovine serum. The effects of high glucose (50 mmol/L and 83 mmol/L) on levels of reactive oxygen species (ROS), on caspase 3 activity, and on phospho-p38 mitogen-activated protein kinase (MAPK) in the cultures were evaluated. Results: Exposure to high glucose (for 4, 8, and 24 hours) increased intracellular levels of ROS and phospho-p38 MAPK (indices of cellular toxicity). Atorvastatin blocked these toxic effects of high glucose, being more effective against 50 mmol/L glucose (protective effects were observed above 0.5 μmol/L) than against 83 mmol/L (protective effects were observed above 2.5 μmol/L). Atorvastatin was also able to prevent glucose-induced increase in caspase 3 activity. Conclusions: The present study shows that high glucose may promote oxidative stress and may activate apoptotic pathways in rat PMCs. These toxic effects could be reversed byatorvastatin. © 2011 International Society for Peritoneal Dialysis.


PubMed | Complejo Hospitalario Universitario Albacete
Type: Journal Article | Journal: The Laryngoscope | Year: 2011

To investigate the level of hearing loss and the configuration of the mean audiometric curve over the course of Menires disease, correcting the data according to patient age.A retrospective study of 3,963 hearing tests.Descriptive, longitudinal study of pure-tone audiometries of 237 patients at a tertiary hospital who had been diagnosed with definitive Menires disease according to the American Academy of Otorhinolaryngology criteria. All audiometric results were age-corrected, and patients were followed for 1 to 31 years. In patients who had undergone surgery, only the data collected before the operation were assessed.In patients with unilateral disease, the mean hearing loss was characteristically low frequency, even in very advanced stages of the disease. Hearing loss was accentuated at 5 and 15 years from onset. In bilateral cases, hearing loss was slightly more severe and the average loss produced a flatter audiometric curve than in unilateral cases.In Menires disease, audiometry results corrected for patient age show an inherent upward-sloping configuration of the mean audiometric curve at all time points during the disease. The hearing pattern differs between unilateral and bilateral disease. The audiometric curve configuration may be an indicator of future bilateral disease.


PubMed | Complejo Hospitalario Universitario Albacete
Type: Case Reports | Journal: Revista espanola de cirugia ortopedica y traumatologia | Year: 2013

A case is presented of a 69 year old male patient with a history of wrist fracture from over 50 years ago with pain refractory to analgesics and with joint destruction of the wrist in conventional radiology. We have conducted a review of extrapulmonary tuberculous osteoarthritis discussing the diagnosis and treatment of this unusual presentation of the disease.


PubMed | Inorganica y Bioquimica, Organica y Bioquimica, University Paris - Sud, University of Castilla - La Mancha and 2 more.
Type: Journal Article | Journal: Oncotarget | Year: 2015

Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new therapeutic strategies to cisplatin resistance, we evaluated, in a model of lung cancer (H1299 and H460 cell lines), the nature of the pathways leading to cell death. We observed that H1299 displayed a natural resistance to cisplatin due to an inability to trigger an apoptotic response that correlates with the induction of autophagy. However, pharmacological and genetic approaches showed how autophagy was a mechanism associated to cell death rather than to resistance. Indeed, pro-autophagic stimuli such as mTOR or Akt inhibition mediate cell death in both cell lines to a similar extent. We next evaluated the response to a novel platinum compound, monoplatin, able to promote cell death in an exclusive autophagy-dependent manner. In this case, no differences were observed between both cell lines. Furthermore, in response to monoplatin, two molecular hallmarks of cisplatin response (p53 and MAPKs) were not implicated, indicating the ability of this pro-autophagic compound to overcome cisplatin resistance. In summary, our data highlight how induction of autophagy could be used in cisplatin resistant tumours and an alternative treatment for p53 mutated patient in a synthetic lethally approach.


PubMed | Complejo Hospitalario Universitario Albacete
Type: Journal Article | Journal: Audiology & neuro-otology | Year: 2012

To investigate the sequence and correlation of symptoms of Mnires disease (MD) depending on their order of manifestation.Descriptive, longitudinal study of the symptoms in 237 tertiary hospital patients who had been diagnosed with definite MD according to the criteria of the American Academy of Otolaryngology. Patients were followed for 1-31 years.Disease began with the three classic symptoms in only 40% of the patients. We recorded the mean, median and maximum time needed to complete the symptoms as well as the time elapsed in some patients from disease onset in one ear to bilateral involvement.We reckon that this study may be of great help in ruling out a diagnosis of MD when the patient presents with only one or two symptoms of the triad. Furthermore, regarding the planning of treatment, the time interval between unilateral and bilateral involvement (5-7 years) is very important since bilateral involvement has great repercussions on treatment, especially surgical treatment.

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