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Zyoud S.H.,Universiti Sains Malaysia | Al-Jabi S.W.,Community Pharmacy | Sweileh W.M.,An Najah National University | Awang R.,Universiti Sains Malaysia
Harm Reduction Journal

Background: Tobacco smoking is the main health-care problem in the world. Evaluation of scientific output in the field of tobacco use has been poorly explored in Middle Eastern Arab (MEA) countries to date, and there are few internationally published reports on research activity in tobacco use. The main objectives of this study were to analyse the research output originating from 13 MEA countries on tobacco fields and to examine the authorship pattern and the citations retrieved from the Scopus database.Methods: Data from 1 January 2003 through 31 December 2012 were searched for documents with specific words regarding the tobacco field as 'keywords' in the title in any 1 of the 13 MEA countries. Research productivity was evaluated based on a methodology developed and used in other bibliometric studies.Results: Five hundred documents were retrieved from 320 peer-reviewed journals. The greatest amount of research activity was from Egypt (25.4%), followed by the Kingdom of Saudi Arabia (KSA) (23.2%), Lebanon (16.3%), and Jordan (14.8%). The total number of citations for the 560 documents, at the time of data analysis (27 August 2013), was 5,585, with a mean ± SD of 9.95 ± 22.64 and a median (interquartile range) of 3(1-10). The h-index of the retrieved documents was 34. This study identified 232 (41.4%) documents from 53 countries in MEA-foreign country collaborations. By region, MEA collaborated most often with countries in the Americas (29.6%), followed by countries in the same MEA region (13.4%), especially KSA and Egypt.Conclusions: The present data reveal a promising rise and a good start for research productivity in the tobacco field in the Arab world. Research output is low in some countries, which can be improved by investing in more international and national collaborative research projects in the field of tobacco. © 2014 Zyoud et al.; licensee BioMed Central Ltd. Source

OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, adverse events, dosing, and administration of intranasal fentanyl spray in the treatment of breakthrough cancer pain (BTCP) in adults. DATA SOURCES: Relevant published data were identified using PubMed from inception to April 2012 using the search terms fentanyl nasal spray, intranasal fentanyl, intranasal fentanyl cancer pain, and fentanyl pectin cancer pain. Only articles evaluating the use of intranasal fentanyl spray for cancer pain were selected. STUDY SELECTION AND DATA EXTRACTION: All articles evaluating the pharmaco-kinetics of intranasal fentanyl or the clinical efficacy of intranasal fentanyl spray for the treatment of BTCP were considered; references of selected articles were manually reviewed to identify further articles. The manufacturer of intranasal fentanyl spray was also contacted to obtain information. DATA SYNTHESIS: Intranasal fentanyl spray gained Food and Drug Administration approval for the treatment of BTCP in adults with cancer receiving stable background opioid therapy for chronic pain. In doses ranging from 100 to 800 μg/ spray, intranasal fentanyl spray was found to be more effective than placebo and more effective than oral morphine or oral fentanyl formulations in reducing pain for up to 15-45 minutes; onset of analgesia was also improved with intranasal fentanyl spray. The most commonly observed adverse events included nausea, vomiting, vertigo, and dizziness. CONCLUSIONS: For the treatment of BTCP, intranasal fentanyl spray offers improved onset of analgesia compared to other oral therapies; this improved onset of analgesia may closely mimic the typical time course of a BTCP episode. Nasal administration may overcome problems such as nausea, vomiting, or xerostomia that may complicate oral administration of analgesics. Potential disadvantages include uncertainty in treating more than 4 BTCP episodes per 24 hours and a higher cost compared to generically available oral opioid analgesics. Source

Zyoud S.H.,Universiti Sains Malaysia | Al-Jabi S.W.,Community Pharmacy | Sweileh W.M.,An Najah National University
Tobacco Induced Diseases

Background: Waterpipe tobacco smoking has spread worldwide. However, the evaluation of scientific output in the field of waterpipe tobacco smoking has not been studied yet. The main objectives of this study were to analyze worldwide research output in the waterpipe tobacco smoking field, and to examine the authorship pattern and the citations retrieved from the Scopus database for over a decade. Methods. Data from January 1, 2003 through December 31, 2012 were searched for documents with specific words regarding waterpipe tobacco smoking as "keywords" in the title. Scientific output was evaluated based on a methodology developed and used in other bibliometric studies: (a) total and trends of contributions in waterpipe tobacco smoking research between 2003 and 2012; (b) authorship patterns and research productivity; (c) collaboration patterns; (d) the citations received by the publications; and (e) areas of interest of the published papers. Results: Worldwide there were 334 publications that met the criteria during the study period. The largest number of publications in waterpipe tobacco smoking were from the United States of America (USA) (33.5%), followed by Lebanon (15.3%), and France (10.5%). The total number of citations at the time of data analysis (October 18, 2013) was 4,352, with an average of 13 citations per document and a median (interquartile range) of 4.0 (1.0-16.0). The h-index of the retrieved documents was 34. The highest h-index by country was 27 for the USA, followed by 20 for Syrian Arab Republic and Lebanon. Conclusions: The present data reveal a promising rise and a good start for research activity in the field of waterpipe tobacco smoking. More effort is needed to bridge the gap in waterpipe smoking-based research and to promote better evaluation of waterpipe smoking, risks, health effects, or control services worldwide. © 2014 Zyoud et al.; licensee BioMed Central Ltd. Source

Background: Middle East respiratory syndrome coronavirus (MERS-CoV) is a virus that causes severe viral pneumonia in humans, known to have a high mortality rate and a similarity in clinical symptoms with severe acute respiratory syndrome coronavirus. It was first isolated in Kingdom of Saudi Arabia (KSA) in 2012 and after that, MERS-CoV exhibited outbreaks in several regions of the world. This study aimed to assess the characteristics of publications involving MERS-CoV at global level by using a bibliometric analysis. Methods: Scopus database was searched on March 4, 2016 for MERS-CoV publications published between 2012 and 2015. It was performed on the same day in order to avoid the possible bias came from update on the database because the metrics are changing over time. All publication types were considered; however publications as errata were excluded. Analysis parameters include year of publication, publication type, patterns of international collaboration, research institutions, journals, impact factor, h-index, language, and times cited. Results: A total of 883 MERS-CoV research publications were published across the world. The MERS-CoV-associated publications were originated from 92 countries/territories, indicating the international spread of MERS-CoV research. The USA was the largest contributor, with 319 articles published over 4 years, followed by KSA (113 articles). The total number of citations for these publications has already achieved 8,015, with an average of 9.01 citations per each publication. The h-index for MERS-CoV-associated publications was 48. The USA also have the highest h-index (32), followed by KSA (26) and UK (22). Netherland produced the greatest proportion of publications with international research collaboration (72.7 %) followed by the UK (71 %) and Germany (69.1 %) out of the total number of publications for each country. Conclusions: There is a rapid increase in research activities related to MERS-CoV from 2012 to 2015. This study demonstrates that the MERS-CoV related literature has grown to be more extensive and global over the past 4 years. The bulk of publications in the field of MERS-CoV research are published by high-income countries such as the USA. Furthermore, the USA, the UK and KSA may have higher quality of articles according to the value of h-index. © 2016 The Author(s). Source

Tachfouti N.,Community Pharmacy
Journal for healthcare quality : official publication of the National Association for Healthcare Quality

In Morocco, injuries account for 11% of total burden of disease. Better organization of emergency care can improve the outcome of trauma patients. In Morocco, these services have been reorganized recently, but were never evaluated. The objective was to assess actual structure and processes of emergency trauma care in a Moroccan region. This comparative qualitative study was carried out in the region of Fez. The process and structure of contacting emergency care and prehospital emergency care were compared with the French 2002 standards. Emergency care at the University Teaching Hospital (UTH) was compared with World Health Organization 2005 Essential Trauma Care guidelines. Predefined care items were categorized as conforming to the standards or not. An emergency call center with a dedicated dial-up number has been established in the region since January 2007. Compared with the standards, this center was not protected by any legislation and was run by interns only. The center was underutilized during triage to help transportation of severe trauma patients. At the prehospital care level, only 3 out of 15 ambulances were equipped with resuscitation equipment and were used rarely. Only one of the ambulance staff out of three was trained in required skills. At the UTH, emergency care equipment and staff was nearly adequate. This study identified several opportunities for improvement in organizing trauma care in Fez particularly at emergency call center and ambulance service. A quality assurance program would be useful to further identifying improvements in this system. © 2010 National Association for Healthcare Quality. Source

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