Time filter

Source Type

Carrascosa A.,Autonomous University of Barcelona | Carrascosa A.,Committee for GH and Growth Factor Therapy of the Catalan Ministry of Health | Carrascosa A.,Hospital Universitario Vall dHebron | Audi L.,Autonomous University of Barcelona | And 12 more authors.
Hormone Research in Paediatrics | Year: 2011

Background/Aims: In prepubertal short children with idiopathic growth retardation, growth hormone (GH) peak after GH release stimuli classifies patients as growth hormone- deficient (GHD) or non-GHD. This study compared a 2-year growth response to GH therapy in 318 prepubertal short children. Methods: Patients were classified as: severe GHD (GH peaks <5 ng/ml after 2 stimuli; n = 54), mild GHD (GH peaks <10 ng/ml, but one or two between 5 and 10 ng/ml; n = 140), dissociated GH release (GH peak ≥10 ng/ml after 1 stimulus and <10 ng/ml after the other; n = 89), and normal GH release (GH peaks ≥10 ng/ml after 2 stimuli; n = 35). Results: Two-year height gain did not differ statistically among the 4 groups: 1.39 ± 0.51 SD, 16.4 ± 2.3 cm; 1.23 ± 0.56 SD, 15.8 ± 2.1 cm; 1.18 ± 0.53 SD, 15.3 ± 2.0 cm, and 1.14 ± 0.53 SD, 15.4 ± 2.0 cm, respectively, as was also the case for bone age gain: 2.5 ± 0.6, 2.4 ± 0.7, 2.6 ± 0.7 and 2.3 ± 0.5 years, respectively. Conclusions: Our results suggest that GH release stimuli are of little help for deciding on GH therapy in the clinical management of prepubertal short children with idiopathic growth retardation, while well-defined anthropometric and biochemical criteria may be useful. Copyright © 2010 S. Karger AG, Basel.

Loading Committee for GH and Growth Factor Therapy of the Catalan Ministry of Health collaborators
Loading Committee for GH and Growth Factor Therapy of the Catalan Ministry of Health collaborators