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McCarthy A.D.,Catedra de Bioquimica Patologica | McCarthy A.D.,National University of La Plata | Curciarello R.,Catedra de Bioquimica Patologica | Castiglione N.,Catedra de Bioquimica Patologica | And 12 more authors.
Acta Diabetologica | Year: 2010

In all, 1,702 unselected pregnant women from the city of La Plata were tested for gestational diabetes mellitus (GDM) and evaluated to determine GDM prevalence and risk factors. In women with GDM, we evaluated compliance with guidelines for GDM management, and perinatal complications attributable to GDM. GDM prevalence was 5.8%, and its risk factors were pre-gestational obesity, previous hyperglycaemia, age > 30 years, previous GDM (and its surrogate markers). In primi-gravida (PG) subjects, GDM was equally prevalent in the presence (4.2%) or absence (4.0%) of risk factors. In multi-gravida (MG) women, although risk factors doubled the prevalence of GDM (8.6%), in the absence of risk factors GDM prevalence was similar to that of PG women (3.9%). Half of all women with GDM received inadequate post-diagnosis obstetric control, and this induced a fourfold increase in infant perinatal complications. In conclusion, all nonhyperglycaemic 24-28-week pregnant women should be tested for GDM, although particular attention must be paid to MG women with risk factors. © Springer-Verlag 2010.


Tognetti J.A.,Comision de Investigaciones Cientificas de la Provincia de Buenos Aires CIC | Tognetti J.A.,University of Buenos Aires | Pontis H.G.,Fundacion para Investigaciones Biologicas Aplicadas | Martinez-Noel G.M.A.,Fundacion para Investigaciones Biologicas Aplicadas | Martinez-Noel G.M.A.,CONICET
Plant Signaling and Behavior | Year: 2013

The role of sucrose as a signaling molecule in plants was originally proposed several decades ago. However, recognition of sucrose as a true signal has been largely debated and only recently this role has been fully accepted. The best-studied cases of sucrose signaling involve metabolic processes, such as the induction of fructan or anthocyanin synthesis, but a large volume of scattered information suggests that sucrose signals may control a vast array of developmental processes along the whole life cycle of the plant. Also, wide gaps exist in our current understanding of the intracellular steps that mediate sucrose action. Sucrose concentration in plant tissues tends to be directly related to light intensity, and inversely related to temperature, and accordingly, exogenous sucrose supply often mimics the effect of high light and cold. However, many exceptions to this rule seem to occur due to interactions with other signaling pathways. In conclusion, the sucrose role as a signal molecule in plants is starting to be unveiled and much research is still needed to have a complete map of its significance in plant function. © 2013 Landes Bioscience.


Conti J.P.,Comision de Investigaciones Cientificas de la Provincia de Buenos Aires CIC | Ceriani M.C.,CONICET | Juliarena M.A.,CONICET | Esteban E.N.,National University of Central Buenos Aires
Informacion Tecnologica | Year: 2012

Proteins and peptides present in fresh whey and after fermentation to be transformed in a fluid base appropriate to prepare functional beverages were studied. With the SDS-PAGE technique (sodium dodecyl sulfate polyacrylamide gel electrophoresis) it was observed total digestion of high molecular weight proteins such as lactoferrin and serum albumin. Immunoglobulin heavy chains suffered a partial digestion and the light chains were not affected. The major proteins β-lactoglobulin and α-lactalbumin did not experience any change. The peptide analysis of the cool whey and base fluid showed a profound change in the post-fermentation profile, with a distribution of 1.000 to 6.000 Dalton. The range of pre-fermentation peptides was 1.500 to 18.000 Dalton. The fermentation process caused a decrease in pH to 3.5 and increased the thermal stability of proteins. The results suggest that whey transformed by this method is a suitable fluid base for designing functional beverages.


Arganaraz J.P.,Comision de Investigaciones Cientificas de la Provincia de Buenos Aires CIC | Arganaraz J.P.,National University of Central Buenos Aires | Arganaraz J.P.,National University of Cordoba | Entraigas I.,National University of Central Buenos Aires
Ecological Informatics | Year: 2014

Understanding the relationship between landscape pattern and environmental processes requires quantification of landscape pattern at multiple scales. This will make it possible to relate broad-scale patterns to fine-scale processes and vice versa. In this study, we used class level landscape metrics calculated at multiple scales to fit scaling functions that were used to downscale metrics at higher resolutions. The main objectives were to assess the performance of different type of functions (i.e. power, logarithmic, etc.) to downscale metrics at the subpixel level and to analyze the variability of the accuracy of subpixel estimates among patch classes for each landscape metric. We used thirteen frequently used landscape metrics, computed on a land use/land cover map derived from Landsat imagery through visual interpretation and supervised classification using Support Vector Machines. The performance of scaling functions was assessed with the Accuracy Improvement percentage (AI). In general, the power function fitted better for most landscape metrics and classes; however, in several cases, more than one type of function showed similar R2 values. Accuracy of subpixel estimates was very variable among landscape metrics and also among patch classes within a metric. The amount of variation was such that no generalization about the predictability of a landscape metric calculated at the class level was possible. Indeed, predictability seemed to be more of a characteristic of the class than a characteristic of the landscape metric. Additionally, the goodness of fit of the scaling functions was not a good indicator of the functions' ability to downscale landscape metrics accurately, indicating that different scaling functions should be analyzed when downscaling landscape metrics at higher resolutions is required. © 2014 Elsevier B.V.


Tano de la Hoz M.F.,Comision de Investigaciones Cientificas de la Provincia de Buenos Aires CIC | Tano de la Hoz M.F.,CONICET | Flamini M.A.,National University of La Plata | Diaz A.O.,CONICET
Acta Zoologica | Year: 2014

The general objective of this study focused on the duodenal histological and histochemical analysis of fetuses and adults of plains viscacha (Lagostomus maximus) from the Buenos Aires province (Argentina). Histological techniques, histochemical procedures for localizing and characterizing glycoproteins (GPs) and lectin histochemical techniques for the identification of specific sugar residues were used. The duodenal structure of all age groups here considered was typical of mammals. We identified a proliferation phase and an epithelial morphogenesis in mid-gestational fetuses, an intermediate period of cell differentiation in at-term fetuses and a posterior stage of physiological maturation in adults. According to histochemistry, the diverse GPs elaborated and secreted into the duodenum show a high degree of histochemical complexity related to the multiple functions of mucus in the digestive tract. The GPs in the duodenum of L. maximus and their glycosylation patterns varied according to the animal's age and the developmental state of the organ. © 2012 The Royal Swedish Academy of Sciences.

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