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Dhaka, Bangladesh

Khondker L.,Bangabandhu Sheikh Mujib Medical University | Khan M.S.I.,Combined Military hospital CMH
Journal of Pakistan Association of Dermatologists | Year: 2014

Objective: To find out the clinical profile of cutaneous drug reactions in a tertiary level hospital. Methods: In this cross-sectional study, carried out for a period from January 2011 to December 2011, data were collected from the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Patients suffering from adverse drug reactions were the study population and within the period of data collection, twenty patients were selected. Results: Out of total twenty patients, 9 (45%) had fixed drug eruptions, 4 (20%) urticaria, 3 (15%) Stevens-Johnson syndrome, 2 (10%) morbilliform rashes and 2 (10%) had erythema multiforme. The most common clinical presentation was hyperpigmented macule/patch in 5 (25%) cases, followed by urticarial plaque 4 (20%), erosive lesion 3 (15%) and loss of skin in sheets <10% body surface area 3 (15%) and morbilliform rashes and target lesions in 2(10%) each. 6 (30%) patients developed mucosal involvement only and majority of them 8 (40%) had oral involvement. The most common type of offending drug causing the drug reactions were sulfur containing drugs in 8 (40%) cases, followed by NSAIDs in 6 (30%), quinolones 3 (15%), metronidazole and anticonvulsants in a few. Conclusion: The common types of cutaneous drug eruptions are fixed drug eruptions, urticaria, Stevens-Johnson syndrome, morbilliform rashes and erythema multiforme. Source

Khondker L.,Bangabandhu Sheikh Mujib Medical University | Islam Khan M.S.,Combined Military hospital CMH
Journal of Pakistan Association of Dermatologists | Year: 2015

Objective To compare the adverse effects of low-dose oral prednisolone and oral mini pulse dexamethasone in patients of vitiligo. Methods A clinical trial was carried out from January 2013 to December 2013. Total sixty patients of vitiligo were enrolled and 30 of group A patients were treated with low dose oral prednisolone (0.3 mg/kg body weight) daily and 30 of group B patients were treated with oral dexamethasone pulse therapy (10 mg per week) for 16 weeks. Results During 12 week follow-up, increased body weight, headache, dyspepsia and fatigue were more frequent in group A as compared to group B. Similarly, in group A other side effects noted were acne (33.3%), mooning of face (26.6%), striae (26.6%), hypertrichosis 13.2%, purpura (6.7%) and among the female patients, menstrual abnormality (71.4%) whereas in group B, no patient developed these problems from baseline to follow-up period (p<0.05). Conclusion Low dose oral prednisolone was found to be associated with more adverse effects than oral dexamethasone pulse therapy in treating vitiligo. Source

Jamal S.,Armed Forces Institute of Pathology AFIP | Atique M.,Combined Military hospital CMH | Khadim M.T.,PNS Shifa
Journal of the Pakistan Medical Association | Year: 2014

Objective: To assess the pattern of malignancies from tumour registry data and to find any changing pattern by comparing corresponding data from earlier periods. Methods: The descriptive study was carried out at the Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan. All malignant tumours from 2002-2011 were analysed for age groups, gender distribution, and type of tumour with relation to the site. Tumours of paediatric age group were also assessed separately. Comparison with national and international studies and the data of previous decades - 1977-1988 and 1992-2001 was done to find any changing pattern. SPSS 15 was used for statistical analysis. Results: A total of 32718 malignant tumours were analysed. Of them, males were 19191 and 13527 were females (M:F ratio: 1.4:1). Majority of the patients were between 50-70 years of age. In males, urinary bladder tumours 2153 (11.2%), followed by combined lymphoma/leukaemia 2020 (10.5%) and prostate 1825 (9.5%) were top three malignancies, whereas in females breast 4178 (30.9%) was the commonest. Comparison of different decades showed that in males in the first monograph lymphoma was the commonest, then it was prostatic carcinoma in the second monograph, and now tumours of urinary bladder were on top position. In females, carcinoma cervix, which was at number 5 and 9 in the two earlier monographs was not found in the list of current 10 common tumours. Conclusion: The study showed some interesting features, particularly in male malignancies and those related to urinary bladder tumours. The persistent increasing frequency of breast carcinoma in females is also alarming, and requires extensive efforts of awareness, screening and early detection programmes. Source

Alam M.N.,Bangabandhu Sheikh Mujib Medical University | Wahab M.A.,Bangabandhu Sheikh Mujib Medical University | Khondker L.,Bangabandhu Sheikh Mujib Medical University | Khan M.S.I.,Combined Military hospital CMH
Journal of Pakistan Association of Dermatologists | Year: 2014

Objective: To compare the efficacy and safety of topical calcipotriol ointment (0.005%) and betamethasone dipropionate (0.05%) cream, given alone and in combination, in treatment of localized vitiligo. Methods :It was a clinical trial conducted from January 2012 to August 2012. Patients of localized vitiligo attending outpatient department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Dhaka were the study population. In group A, 20 patients applied betamethasone dipropionate cream 0.05% in the morning and topical calcipotriene ointment (0.005%) in the evening, in group B, 20 patients applied betamethasone dipropionate cream 0.05% twice daily; In group C, 20 patients used calcipotriene ointment 0.005%. Results :in The vitiligo score in group A, B and C reduced from 26, 25 and 23, respectively to 3, 8 and 6 (p<0.05). The side effects experienced by patients at 5th follow-up were: in group A erythema (15%), dryness (15%), scaling (5%) and pruritus (5%); in group B, erythema (15%), scaling (5%), dryness (5%) and pruritus (5%); and in group C, erythema (10%) [p=0.005]. Conclusion : Both the drugs, calcipotriol and betamethasone dipropionate when used individually as monotherapy, were found to be equally effective in the treatment of vitiligo, but the combination of the two was found to be superior in efficacy. Regarding safety level, calcipotriene and betamethasone dipropionate when used individually, were found to be safer in the treatment of vitiligo, than the combination of the two. Source

Mansoor J.,Combined Military hospital CMH | Umair B.,Combined Military hospital CMH
Journal of the College of Physicians and Surgeons Pakistan | Year: 2013

Primary pancreatic tuberculosis is an extremely rare entity, even in tuberculosis endemic areas. A 22-year-old male presented with features of obstructive jaundice. Ultrasonography and computed tomography scan showed mass in the pancreatic head for which he underwent a pancreatoduodenectomy. Histological examination of the specimen showed caseating granulomas. Antituberculous medicines were started and he remained well 18 months after surgery. Pancreatic tuberculosis is rare and is frequently confused with pancreatic cancer on clinical presentation as well as on imaging studies. A high index of suspicion is vital to avoid surgeries in this medically treatable, often misdiagnosed condition. © 2013 College of Physicians and Surgeons Pakistan. Source

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