New York City, NY, United States

Columbia University

www.columbia.edu
New York City, NY, United States

Columbia University in the City of New York, or simply Columbia University, is an American private Ivy League research university located in the Morningside Heights neighborhood of Upper Manhattan in New York City. It is the oldest institution of higher learning in the State of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the American Revolution. Today the university operates Columbia Global Centers overseas in Amman, Beijing, Istanbul, Paris, Mumbai, Rio de Janeiro, Santiago and Nairobi.The university was founded in 1754 as King's College by royal charter of George II of Great Britain. After the American Revolutionary War, King's College briefly became a state entity, and was renamed Columbia College in 1784. The University now operates under a 1787 charter that places the institution under a private board of trustees, and in 1896 it was further renamed Columbia University. That same year, the university's campus was moved from Madison Avenue to its current location in Morningside Heights, where it occupies more than six city blocks, or 32 acres .The university encompasses twenty schools and is affiliated with numerous institutions, including Teachers College , Barnard College, and the Union Theological Seminary, with joint undergraduate programs available through the Jewish Theological Seminary of America as well as the Juilliard School.Columbia annually administers the Pulitzer Prize. 101 Nobel Prize laureates have been affiliated with the university as students, faculty, or staff, the second most of any institution in the world. Columbia is one of the fourteen founding members of the Association of American Universities, and was the first school in the United States to grant the M.D. degree. Notable alumni and former students of the university and its predecessor, King's College, include five Founding Fathers of the United States; nine Justices of the United States Supreme Court; 43 Nobel Prize laureates; 20 living billionaires; 28 Academy Award winners; and 29 heads of state, including three United States Presidents. Wikipedia.

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Patent
Columbia University | Date: 2017-03-01

Active wearable body brace embodiments provide selectable conformation control of the interface between the trunk of a human subject and the brace, which conformation may be varied over time and responsively to feedback and an updateable prescription. Further active wearable body brace embodiments provide selectable movement control of the interface between the trunk of a human subject and the brace with up to six degrees of freedom between elements to allow a controller to implement operations such as muscle challenges, active support, and passive-like support where actuators mimic springs. Further embodiments may also provide detection functions such as quantifying muscle weakness. The features of these embodiments may be combined in various ways to provide still further embodiments.


Patent
Columbia University | Date: 2017-01-18

The present invention provides a compound having the structure (I) or a pharmaceutically acceptable salt or ester thereof.


Systems for machine-based rehabilitation of movement disorders including gait therapy applications can apply controlled forces to the pelvis and/or other body parts including knee and ankle joints. Cable-driven systems for gait therapy applications can apply controlled forces to, in respective embodiments, the pelvis and the pelvis, knee and ankle joints. In further embodiments, systems for gait therapy can be treadmill-based or walker-based. In embodiments, a controlled downforce is applied to the hip with augmentation including supportive forces. In further embodiments, the technology is activated through cables that provide support and limb-flexing moments with low inertia and friction resistance. In further embodiments, assistance is configured for gait therapy in children. In still further embodiments, methods of rehabilitation and assist-as-needed (AAN) control of the gait therapy systems facilitate a patients ability to coordinate movement, control balance, achieve strength, and other beneficial outcomes.


Patent
Columbia University | Date: 2017-03-01

A three-dimensional cancer culture model is provided suitable for chemotherapeutic testing and metastasis mechanism study.


Patent
Columbia University | Date: 2017-05-03

An apparatus for controlled perforation and aspiration of the inner ear.


Patent
The United States As Represented By The Secretary, Columbia University, Center For The Aids Programme Of Research In South Africa, University of Witwatersrand and National Health Laboratory Service | Date: 2017-01-04

The present invention relates anti-HIV therapies and prophylaxis. Specifically, the invention relates to broadly neutralizing antibodies against HIV-1, nucleic acids encoding these antibodies, vectors comprising the nucleic acids and cells and pharmaceutical compositions Comprising said vectors and/or antibodies. The present invention also relates to use of the antibodies and/or vectors for the treatment and/or prevention of HIV-1 infection in a subject. Furthermore, the invention also relates to a kit containing the antibodies of the invention.


Disclosed herein are methods involving the targeting of 5HT biosynthesis in gut insulin-negative cells to convert them into insulin-positive cells. Also disclosed are methods for treating a disease or disorder in a mammal, preferably a human, associated with impaired pancreatic endocrine function, by administering a therapeutically effective amount of an enumerated active agent that reduces the expression, biosynthesis, signaling or biological activity of serotonin or increases its degradation, wherein administering comprises delivering the agent to Gut Ins- cells in the mammal. Other embodiments of the method are directed to therapy wherein an agent that significantly reduces FOXO1 expression, biosynthesis, signaling or biological activity or increases its degradation is administered in addition to the agent that reduces serotonin, or alternatively an agent that reduces FOXO1 expression is targeted to serotonin-positive gut enteroendocrine cells.


Patent
Columbia University | Date: 2017-01-24

A method for selecting and isolating aptamers that target M-Ig proteins with a microdevice including at least a first selection chamber is provided. The method includes preparing a first sample of M-Ig proteins from a serum; placing the M-Ig proteins in the first selection chamber; introducing a first group of oligomers including at least an M-Ig targeting oligomer into the first selection chamber, whereby the M-Ig targeting oligomer binds to the first sample of M-Ig proteins. The method further includes removing unbound oligomers of the first sample from the first selection chamber to isolate the M-Ig targeting oligomer.


Patent
Columbia University | Date: 2017-01-18

A customized allograft that is bendable and suitable for allografting of an articular joint, including the thumb.


Patent
Columbia University | Date: 2017-01-18

Disclosed here are antimicrobial compositions comprising mixtures of essential oils, botanical extracts and synthetic antimicrobial agents which do not rely solely upon alcohol to produce their antimicrobial effects. The antimicrobial compositions can further comprise alkanediols. The compositions described herein can be used in low concentrations, for example, after diluting with water or a disinfectant/antiseptic solution.

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