Columbia University in the City of New York, or simply Columbia University, is an American private Ivy League research university located in the Morningside Heights neighborhood of Upper Manhattan in New York City. It is the oldest institution of higher learning in the State of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the American Revolution. Today the university operates Columbia Global Centers overseas in Amman, Beijing, Istanbul, Paris, Mumbai, Rio de Janeiro, Santiago and Nairobi.The university was founded in 1754 as King's College by royal charter of George II of Great Britain. After the American Revolutionary War, King's College briefly became a state entity, and was renamed Columbia College in 1784. The University now operates under a 1787 charter that places the institution under a private board of trustees, and in 1896 it was further renamed Columbia University. That same year, the university's campus was moved from Madison Avenue to its current location in Morningside Heights, where it occupies more than six city blocks, or 32 acres .The university encompasses twenty schools and is affiliated with numerous institutions, including Teachers College , Barnard College, and the Union Theological Seminary, with joint undergraduate programs available through the Jewish Theological Seminary of America as well as the Juilliard School.Columbia annually administers the Pulitzer Prize. 101 Nobel Prize laureates have been affiliated with the university as students, faculty, or staff, the second most of any institution in the world. Columbia is one of the fourteen founding members of the Association of American Universities, and was the first school in the United States to grant the M.D. degree. Notable alumni and former students of the university and its predecessor, King's College, include five Founding Fathers of the United States; nine Justices of the United States Supreme Court; 43 Nobel Prize laureates; 20 living billionaires; 28 Academy Award winners; and 29 heads of state, including three United States Presidents. Wikipedia.
Columbia University | Date: 2016-12-02
The invention provides for methods for treating an inflammatory disease of the digestive system in a subject by administering a trefoil family molecule. The invention provides for methods for treating a digestive system cancer in a subject by administering a trefoil family molecule. The invention provides for methods for cell proliferation in a subject by administering a trefoil family molecule.
Columbia University | Date: 2016-12-02
A system includes an electrical device comprising a power supply and circuitry and a supplemental device integrated into the electrical device. The supplemental device includes a tracker chip to receive current location data of the electrical device. The supplemental device also includes a switch with one side connected to the power supply and another side connected to the circuitry of the electrical device. The supplemental device also includes a processor and a memory chip including a stored predetermined location of the electrical device. The predetermined location is input in an encrypted format into a secure encoding chip. The processor is configured to receive the current location data from the tracker chip, compare the current location data with the predetermination location, and turn off the switch to disconnect the power supply from the circuitry if the current location data does not correspond to the predetermined location.
Columbia University | Date: 2016-12-13
The invention is directed to a Ca2+ precipitable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipitable tags and cassettes.
Columbia University | Date: 2017-02-22
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as -hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
Columbia University | Date: 2017-03-01
The present invention concerns a flexible stapling device (1). More particularly, this invention concerns a flexible endovascular stapling device (1) for an intravascular procedure such as patent foramen ovate closure, which is designed to avoid open heart surgery by permitting the closure of the defect utilizing a stapling means (26) which is positioned by using a flexible shaft/guidewire system.
Columbia University | Date: 2016-12-27
Columbia University | Date: 2017-01-03
An introducer configured with a first curve having a first angle that traverses space of an atrial appendage, a central atrium, caudad to the coronary sinus, and a second curve that has an angle sufficient to align the introducer with an intrinsic curvature of the coronary sinus of a subject.
Columbia University | Date: 2016-10-07
The invention discloses a methodology for the culture of bladder cell lines and organoids from human bladder, both non-cancerous as well as cancer tissue.
Northeastern University and Columbia University | Date: 2017-07-12
The invention provides high coercivity magnetic materials based on FeNi alloys having an L10 phase structure, and methods for making the materials.
Hillman E.M.C.,Columbia University
Annual Review of Neuroscience | Year: 2014
Functional magnetic resonance imaging (fMRI) provides a unique view of the working human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blood flow and blood oxygenation, which are coupled to underlying neuronal activity by a process termed neurovascular coupling. Over the past 10 years, a range of cellular mechanisms, including astrocytes, pericytes, and interneurons, have been proposed to play a role in functional neurovascular coupling. However, the field remains conflicted over the relative importance of each process, while key spatiotemporal features of BOLD response remain unexplained. Here, we review current candidate neurovascular coupling mechanisms and propose that previously overlooked involvement of the vascular endothelium may provide a more complete picture of how blood flow is controlled in the brain. We also explore the possibility and consequences of conditions in which neurovascular coupling may be altered, including during postnatal development, pathological states, and aging, noting relevance to both stimulus-evoked and resting-state fMRI studies. © Copyright ©2014 by Annual Reviews. All rights reserved.