Amara S.,Laboratory of Colorectal Cancer Research UR03ES04 |
Amara S.,Tunis el Manar University |
Chaar I.,Laboratory of Colorectal Cancer Research UR03ES04 |
Chaar I.,Tunis el Manar University |
And 9 more authors.
Journal of Immunoassay and Immunochemistry | Year: 2015
The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from normal mucosa to primary tumor (p < 0.05). CRC patients have higher frequency of A allele (52.01%) than controls (26.8%) (P = 0.0001). Thus, SDF-1 polymorphism is a risk factor of colorectal cancer susceptibility in our population, the polymorph genotype of SDF-1 maybe associated with clinical manifestations in CRC patients in Tunisia. © 2015 Taylor & Francis Group, LLC.