Colorado State University–Pueblo is a regional comprehensive public institution of higher learning located in Pueblo, Colorado, United States and considered to be the flagship university for the Pueblo region. CSU-Pueblo is a member of the Colorado State University System , along with the system's flagship and the state's land-grant university, Colorado State University in Fort Collins and Colorado State University-Global Campus, the nation’s first, independent, 100% online public university. Wikipedia.
Melnykov V.,North Dakota State University |
Melnykov I.,Colorado State University-Pueblo
Computational Statistics and Data Analysis | Year: 2012
An approach is proposed for initializing the expectationmaximization (EM) algorithm in multivariate Gaussian mixture models with an unknown number of components. As the EM algorithm is often sensitive to the choice of the initial parameter vector, efficient initialization is an important preliminary process for the future convergence of the algorithm to the best local maximum of the likelihood function. We propose a strategy initializing mean vectors by choosing points with higher concentrations of neighbors and using a truncated normal distribution for the preliminary estimation of dispersion matrices. The suggested approach is illustrated on examples and compared with several other initialization methods. © 2011 Elsevier B.V. All rights reserved. Source
Jackson M.,Colorado State University-Pueblo
Cold Spring Harbor Perspectives in Medicine | Year: 2014
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key aspect of tuberculosis (TB) basic and translational research. Although the interest in these compounds originally stemmed from their abundance, structural diversity, and antigenicity, continued research in this field has been driven by their important contribution to TB pathogenesis and their interest from the perspective of drug, vaccine, diagnostic, and biomarker development. This article summarizes what is known of the roles of lipids in the physiology and pathogenicity of Mtb and the exciting developments that have occurred in recent years in identifying new lead compounds targeting their biogenesis. © 2014 Cold Spring Harbor Laboratory Press; All rights reserved. Source
Jaksic N.I.,Colorado State University-Pueblo
Computers in Education Journal | Year: 2014
This work describes a set of new inexpensive 3D printers and their applications in experiential learning as part of engineering education encompassing two multidisciplinary undergraduate engineering programs: Mechatronics and Industrial Engineering. The work addresses applications of inexpensive 3D printers in support of many engineering and nonengineering courses and activities. Challenges of running a successful 3D-printer lab are addressed. A number of student projects are described. Based on the shear amount of 3D prints and their quality it can be concluded that the acceptance of this technology is high amongst undergraduate engineering students. Source
Varian-Ramos C.W.,Colorado State University-Pueblo |
Swaddle J.P.,College of William and Mary |
Cristol D.A.,College of William and Mary
PLoS ONE | Year: 2014
Mercury is a global pollutant that biomagnifies in food webs, placing wildlife at risk of reduced reproductive fitness and survival. Songbirds are the most diverse branch of the avian evolutionary tree; many are suffering persistent and serious population declines and we know that songbirds are frequently exposed to mercury pollution. Our objective was to determine the effects of environmentally relevant doses of mercury on reproductive success of songbirds exposed throughout their lives or only as adults. The two modes of exposure simulated philopatric species versus dispersive species, and are particularly relevant because of the heightened mercury-sensitivity of developing nervous systems. We performed a dosing study with dietary methylmercury in a model songbird species, the zebra finch (Taeniopygia guttata), at doses from 0.3 - 2.4 parts per million. Birds were exposed to mercury either as adults only or throughout their lives. All doses of mercury reduced reproductive success, with the lowest dose reducing the number of independent offspring produced in one year by 16% and the highest dose, representing approximately half the lethal dose for this species, causing a 50% reduction. While mercury did not affect clutch size or survivorship, it had the most consistent effect on the proportion of chicks that fledged from the nest, regardless of mode of exposure. Among birds exposed as adults, mercury caused a steep increase in the latency to re-nest after loss of a clutch. Birds exposed for their entire lifetimes, which were necessarily the offspring of dosed parents, had up to 50% lower reproductive success than adult-exposed birds at low doses of methylmercury, but increased reproductive success at high doses, suggesting selection for mercury tolerance at the highest level of exposure. Our results indicate that mercury levels in prey items at contaminated sites pose a significant threat to populations of songbirds through reduced reproductive success. © 2014 Varian-Ramos et al. Source
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 306.66K | Year: 2016
This project provides networking infrastructure upgrades to support research and education particularly in STEM disciplines, by implementing a research-level high-speed subnetwork DMZ for the local area network (LAN); adding a data transfer node; deploying the multidomain network measurement/monitoring toolkit known as perfSONAR to improve the ability to identity and isolate network problems and increase productivity; implementing the globus toolkit (software infrastructure for distributed computing, including large file storage and transfer); and installing fiber optic cable to the CSU-Pueblo observatory, providing increased bandwidth for telescope images and video. The research DMZ connects via a 10 Gbps wide area network (WAN) connection to the Front Range GigaPop (FRGP) network, which provides access to multiple research networks including Intra-FRGP, Western Regional Network, Internet2, and ESnet. Upgraded equipment is primarily at Colorado State University - Pueblo (CSU-P) in Pueblo, CO; some optical equipment is housed in Colorado Springs, Monument Hill, and Denver, CO.
The upgrade improves networking for CSU-P, allowing high-speed research to be centralized and supported with networking resources (relieving congestion on CSU-Ps existing LAN and WAN). Nine particular research projects benefit from this project. Broader community impacts include computer science courses incorporating details about this next-generation network, along with transporting, storing, preserving, manipulating, processing and analyzing big data; and the entire community participating remotely in imaging of astronomical events through CSU-Ps observatory telescope. Large datasets generated on campus are preserved regionally on the shared digital repository, and then made accessible and reusable for others.