Pueblo West, CO, United States
Pueblo West, CO, United States

Colorado State University–Pueblo is a regional comprehensive public institution of higher learning located in Pueblo, Colorado, United States and considered to be the flagship university for the Pueblo region. CSU-Pueblo is a member of the Colorado State University System , along with the system's flagship and the state's land-grant university, Colorado State University in Fort Collins and Colorado State University-Global Campus, the nation’s first, independent, 100% online public university. Wikipedia.


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Siegel H.J.,Colorado State University | Siegel H.J.,Colorado State University-Pueblo | Khemka B.,Colorado State University | Friese R.,Colorado State University | And 6 more authors.
2014 7th International Conference on Contemporary Computing, IC3 2014 | Year: 2014

This corresponds to the material in the invited keynote presentation by H. J. Siegel, summarizing the research in [1], [2]. We address the problem of assigning dynamically-arriving tasks to machines in a heterogeneous computing environment. These machines execute a workload composed of different tasks, where the tasks have diverse computational requirements. Each task has a utility function associated with it that represents the value of completing that task, and this utility decreases the longer it takes a task to complete. The goal of our resource manager is to maximize the sum of the utilities earned by all tasks arriving in the system over a given interval of time, while satisfying an energy constraint. We describe example energy-aware resource management methods to accomplish this goal, and compare their performance. We also study the bi-objective problem of maximizing system utility and minimizing the system energy consumption. This analysis technique allows system administrators to investigate the trade-offs between these conflicting goals. © 2014 IEEE.


Fujieda M.,NICT | Gotoh T.,NICT | Ichikawa R.,NICT | Tabuchi R.,NICT | And 21 more authors.
2014 European Frequency and Time Forum, EFTF 2014 | Year: 2014

The T2K experiment uses GPS system to synchronize the timing between J-PARC (Tokai) and Super-Kamiokande (Kamioka). The GPS link was calibrated with 1-ns uncertainty by two mobile TWSTFT stations to improve the synchronization accuracy. © 2014 IEEE.


Sarper H.,Old Dominion University | Blanton C.,Idaho State University | Depalma J.,Colorado State University-Pueblo | Melnykov I.V.,Colorado State University-Pueblo | Gabaldon A.M.,Colorado State University-Pueblo
Life Sciences in Space Research | Year: 2014

This paper reports results on exposure to simulated weightlessness that leads to a rapid decrease in bone mineral density known as spaceflight osteopenia by evaluating the effectiveness of dietary supplementation with synbiotics to counteract the effects of skeletal unloading. Forty adult male rats were studied under four different conditions in a 2×2 factorial design with main effects of diet (synbiotic and control) and weight condition (unloaded and control). Hindlimb unloading was performed at all times for 14 days followed by 14 days of recovery (reambulation). The synbiotic diet contained probiotic strains Lactobacillus acidophilus and Lactococcus lactis lactis and prebiotic fructooligosaccharide. This paper also reports on the development of a desktop three-point bending device to measure the mechanical strength of bones from rats subjected to simulated weightlessness. The importance of quantifying bone resistance to breakage is critical when examining the effectiveness of interventions against osteopenia resulting from skeletal unloading, such as astronauts experience, disuse or disease. Mechanical strength indices provide information beyond measures of bone density and microarchitecture that enhance the overall assessment of a treatment's potency. In this study we used a newly constructed three-point bending device to measure the mechanical strength of femur and tibia bones from hindlimb-unloaded rats fed an experimental synbiotic diet enriched with probiotics and fermentable fiber. Two calculated outputs for each sample were Young's modulus of elasticity and fracture stress. Bone major elements (calcium, magnesium, and phosphorous) were quantified using ICP-MS analysis. Hindlimb unloading was associated with a significant loss of strength in the femur, and with significant reductions in major bone elements. The synbiotic diet did not protect against these unloading effects. Tibia strength and major elements were not reduced by hindlimb unloading, as was the case for femur, but tibia bone strength was negatively affected by the synbiotic diet. Thus, unexpectedly, the synbiotic diet was associated with null or detrimental effects on bone strength. © 2014 The Committee on Space Research (COSPAR).


Forister M.L.,University of Nevada, Reno | Cousens B.,Western Purple Martin Foundation | Harrison J.G.,University of Nevada, Reno | Anderson K.,Colorado State University-Pueblo | And 8 more authors.
Biology Letters | Year: 2016

The butterfly fauna of lowland Northern California has exhibited a marked decline in recent years that previous studies have attributed in part to altered climatic conditions and changes in land use. Here, we ask if a shift in insecticide use towards neonicotinoids is associated with butterfly declines at four sites in the region that have been monitored for four decades. A negative association between butterfly populations and increasing neonicotinoid application is detectable while controlling for land use and other factors, and appears to be more severe for smaller-bodied species. These results suggest that neonicotinoids could influence non-target insect populations occurring in proximity to application locations, and highlights the need for mechanistic work to complement long-term observational data. © 2016 The Author(s).


Herrmann S.J.,Colorado State University-Pueblo | Nimmo D.R.,Colorado State University-Pueblo | Carsella J.S.,Colorado State University-Pueblo | Herrmann-Hoesing L.M.,Washington State University | And 3 more authors.
Archives of Environmental Contamination and Toxicology | Year: 2016

Total mercury (THg) and selenium (Se) were analyzed by Inductively Coupled Plasma Mass Spectrometry in 11 internal and external tissues and stomach contents from 23 brown trout, Salmo trutta, of a 22.9-km reach of a high-gradient stream (upper Fountain Creek) in Colorado, USA, impacted by coal-fired power plants, shale deposits, and urbanization. Trout and water were sampled from four sites ranging from 2335 to 1818 m elevation. Lengths, weights, and ages of fish between pairs of the four sites were not significantly different. The dry weight (dw) to wet weight (ww) conversion factor for each tissue was calculated with egg-ovary highest at 0.379 and epaxial muscle fourth highest at 0.223. THg and Se in stomach contents indicated diet and not ambient water was the major source of Hg and Se bioaccumulated. Mean THg ww in kidney was 40.33 μg/kg, and epaxial muscle second highest at 36.76 μg/kg. None of the tissues exceeded the human critical threshold for Hg. However, all 23 trout had at least one tissue type that exceeded 0.02 mg/kg THg ww for birds, and four trout tissues exceeded 0.1 mg/kg THg ww for mammals, indicating that piscivorous mammals and birds should be monitored. Se concentrations in tissues varied depending on ww or dw listing. Mean Se dw in liver was higher than ovary at the uppermost site and the two lower sites. Liver tissue, in addition to egg-ovary, should be utilized as an indicator tissue for Se toxicity. © 2015 Springer Science+Business Media New York.


Leyva-Corona J.C.,Sonora Institute of Technology | Thomas M.G.,Colorado State University-Pueblo | Rincon G.,University of California at Davis | Medrano J.F.,University of California at Davis | And 5 more authors.
Revista Mexicana De Ciencias Pecuarias | Year: 2016

The objective of this study was to determine the physiological, endocrine and productive response in lactating dairy cows under several series of artificial cooling at the beginning of the summer (June to July, 2011). Fourteen multiparous Holstein cows were assigned in one of two treatments: Cooling (C) before milking (0700 and 1700 h) and additional cooling (AC) each 2 h (from 0700 to 1700h) in the holding pen of the milking parlor. Milk yield (MY), and serum levels of prolactin (PRL) and IGF1 were measured. Rectal temperature and respiratory rate were registered and included as physiological markers of heat stress. Ambient temperature and relative humidity were also collected and used to calculate temperature-humidity index (THI). Both markers of heat stress showed a significant interaction (P<0.001) between treatment and time/week, which were lower in AC treatment (-3.8 breaths per minute and -0.2 °C) during wk 6 and 7. Serum levels of PRL were higher under additional cooling (AC: 35.1 vs C: 29.4 ng/ml; P=0.004), while IGF1 serum levels showed variation only through the sampling weeks (P=0.014). The MY increased (P<0.05) in AC only during wk 6 (+3.1 kg/d) and 7 (+3.1 kg/d). It was concluded that additional cooling at the beginning of the summer reduced heat stress in dairy cows allowing a better productive performance at the end of the study because such effect relied on the variable time/week.


Ou L.,Peking University | Ou L.,College of William and Mary | Varian-Ramos C.W.,Colorado State University-Pueblo | Cristol D.A.,College of William and Mary
Environmental Toxicology and Chemistry | Year: 2015

Bird eggs are used widely as noninvasive bioindicators for environmental mercury availability. Previous studies, however, have found varying relationships between laying sequence and egg mercury concentrations. Some studies have reported that the mercury concentration was higher in first-laid eggs or declined across the laying sequence, whereas in other studies mercury concentration was not related to egg order. Approximately 300 eggs (61 clutches) were collected from captive zebra finches dosed throughout their reproductive lives with methylmercury (0.3 μg/g, 0.6μg/g, 1.2μg/g, or 2.4μg/g wet wt in diet); the total mercury concentration (mean ± standard deviation [SD] dry wt basis) of their eggs was 7.03±1.38μg/g, 14.15±2.52μg/g, 26.85±5.85μg/g, and 49.76±10.37μg/g, respectively (equivalent to fresh wt egg mercury concentrations of 1.24μg/g, 2.50μg/g, 4.74μg/g, and 8.79μg/g). The authors observed a significant decrease in the mercury concentration of successive eggs when compared with the first egg and notable variation between clutches within treatments. The mercury level of individual females within and among treatments did not alter this relationship. Based on the results, sampling of a single egg in each clutch from any position in the laying sequence is sufficient for purposes of population risk assessment, but it is not recommended as a proxy for individual female exposure or as an estimate of average mercury level within the clutch. © 2015 SETAC.


Ma J.,Colorado State University-Pueblo | Zeng D.,CAS Institute of Automation | Zeng D.,University of Arizona | Zhao H.,University of Wisconsin - Milwaukee
Journal of Database Management | Year: 2013

Spatio-temporal data mining is finding applications in many domains, such as public health, public safety, financial fraud detection, transportation, and product lifecycle management. Correlation analysis is an important spatio-temporal mining technique for unveiling spatial and temporal relationships among multiple event types. This paper presents a new measure for assessing and analyzing spatio-temporal cross-correlations. This measure extends Ripley's K(r), a widely used measure of spatial correlation, with an additional temporal dimension. Empirical studies using real-world data show that the new measure can lead to a more discriminating and flexible spatio-temporal data analysis framework. In contrast with its predecessor, this measure also allows the discovery of leading (and potentially causal) event types whose occurrences precede those of other event types. Findings from analyses employing this measure may bear important managerial implications. Copyright © 2013, IGI Global.


Zhang R.,Colorado State University-Pueblo | Cheng X.,Peking University | Yang L.,Colorado State University-Pueblo
2015 IEEE Global Communications Conference, GLOBECOM 2015 | Year: 2015

In this paper, we investigate the cooperation issue via spectrum sharing when employing the physical layer security concept into the Device-to-Device (D2D) communications underlaying cellular network. Different from previously related works, we consider a more general interference case that multiple D2D pairs can access the same resource block (RB) and one D2D pair is also permitted to access multiple RBs, and provide a novel cooperation mechanism in the investigated D2D communications underlaying cellular network. Furthermore, we formulate the provided cooperation mechanism among cellular communication links and D2D pairs as a coalitional game. Then, based on a newly defined Max-Coalition order in the constructed game, we further propose a merge-and-split based coalition formation algorithm for cellular communication links and D2D pairs to achieve efficient and effective cooperation, leading to both improved system secrecy rate and social welfare. Simulation results indicate the efficiency of the designed cooperation mechanism and the proposed merge-and-split based coalition formation algorithm. © 2015 IEEE.


Kuenstner J.T.,Charleston Area Medical Center | Chamberlin W.,Mountain View Regional Hospital | Collins M.T.,University of Wisconsin - Madison | Dow C.T.,5 Damon Street | And 9 more authors.
World Journal of Gastroenterology | Year: 2015

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans. © 2015 Baishideng Publishing Group Inc. All rights reserved.


Persson T.,University of Stockholm | Benson D.R.,University of Connecticut | Normand P.,CNRS Microbial Ecology | Heuvel B.V.,Colorado State University-Pueblo | And 17 more authors.
Journal of Bacteriology | Year: 2011

Members of the noncultured clade of Frankia enter into root nodule symbioses with actinorhizal species from the orders Cucurbitales and Rosales. We report the genome sequence of a member of this clade originally from Pakistan but obtained from root nodules of the American plant Datisca glomerata without isolation in culture. © 2011, American Society for Microbiology.


Persson T.,University of Stockholm | Battenberg K.,University of California at Davis | Demina I.V.,University of Stockholm | Vigil-Stenman T.,University of Stockholm | And 12 more authors.
PLoS ONE | Year: 2015

Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both α- and β-rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors. © 2015 Persson et al.


Toba A.L.,Old Dominion University | Bedoya-Valencia L.,Colorado State University-Pueblo
62nd IIE Annual Conference and Expo 2012 | Year: 2012

Assembly Line Balancing Problems (ALBP) involve production planning in order to improve an existing assembly process or create a new one. The ultimate goal, in regard to high efficiency is to maximize the facility throughput, in function of time, capital investment, resource utilization, customer demands and material handling. In this paper, an approach for balancing a Concentrated Photovoltaic (CPV) solar panel assembly line is proposed, using Discrete Event Simulation (DES). It aims to develop a more efficient CPV solar panel assembly line, which will allow the manufacturing facility to meet the demand, while reducing congestion between workstations within the production process. Several possible scenarios are developed for the deterministic case. These scenarios are then used as benchmarks for their corresponding stochastic scenarios analyzed by a simulation model, considering changing demands and different production capacity. With this proposed approach, the decision maker will be able to select the best assembly line in order to satisfy customers' demand while using time and resources required efficiently.


Zhang R.,Colorado State University-Pueblo | Cheng X.,Peking University | Yang L.,Colorado State University-Pueblo
2016 IEEE International Conference on Communications, ICC 2016 | Year: 2016

In this paper, we investigate the physical layer security issue in Device-to-Device (D2D) communications underlaying cellular networks. In order to optimize the system secrecy rate of the cellular secure communication, we derive the optimal joint power control solutions of both the cellular communication links and D2D pairs in terms of the secrecy capacity. Furthermore, we propose a secrecy-based joint power and access control (JPAC) scheme with optimum D2D pair selection mechanism that can achieve an improved network secrecy performance with very low computational complexity. Simulation results validate the efficiency of the proposed secrecy-based JPAC scheme. © 2016 IEEE.


Schlegel T.T.,NASA | Kulecz W.B.,NASA | Feiveson A.H.,NASA | Greco E.C.,Arkansas Tech University | And 14 more authors.
BMC Cardiovascular Disorders | Year: 2010

Background: Resting conventional 12-lead ECG has low sensitivity for detection of coronary artery disease (CAD) and left ventricular hypertrophy (LVH) and low positive predictive value (PPV) for prediction of left ventricular systolic dysfunction (LVSD). We hypothesized that a ~5-min resting 12-lead advanced ECG test ("A-ECG") that combined results from both the advanced and conventional ECG could more accurately screen for these conditions than strictly conventional ECG.Methods: Results from nearly every conventional and advanced resting ECG parameter known from the literature to have diagnostic or predictive value were first retrospectively evaluated in 418 healthy controls and 290 patients with imaging-proven CAD, LVH and/or LVSD. Each ECG parameter was examined for potential inclusion within multi-parameter A-ECG scores derived from multivariate regression models that were designed to optimally screen for disease in general or LVSD in particular. The performance of the best retrospectively-validated A-ECG scores was then compared against that of optimized pooled criteria from the strictly conventional ECG in a test set of 315 additional individuals.Results: Compared to optimized pooled criteria from the strictly conventional ECG, a 7-parameter A-ECG score validated in the training set increased the sensitivity of resting ECG for identifying disease in the test set from 78% (72-84%) to 92% (88-96%) (P < 0.0001) while also increasing specificity from 85% (77-91%) to 94% (88-98%) (P < 0.05). In diseased patients, another 5-parameter A-ECG score increased the PPV of ECG for LVSD from 53% (41-65%) to 92% (78-98%) (P < 0.0001) without compromising related negative predictive value.Conclusion: Resting 12-lead A-ECG scoring is more accurate than strictly conventional ECG in screening for CAD, LVH and LVSD. © 2010 Schlegel et al; licensee BioMed Central Ltd.


Nedderman A.B.,Dallas Baptist University | Nedderman A.B.,Private Practice | Underwood L.A.,Regent University | Underwood L.A.,Behavioral Health | And 2 more authors.
Journal of Correctional Health Care | Year: 2010

Female offenders are showing a dramatic increase and presenting with several challenges to emotional stability. Current research literature notes the disadvantaged state of these women and psychological profiles reflecting depression, anxiety, trauma, shame, low self-worth, and substance abuse. The instillation of hope has been identified as a therapeutic factor and motivating energy that promotes goal development, reduction of negative emotions, and coping ability. This investigation assessed the impact of hope on female prisoners through the use of a psychoeducational group based on Christian spirituality. Data from the Herth Hope Index were analyzed using a series of t tests to measure group differences. Analysis of the data indicated positive change in the therapy group but did not support statistical significance for every factor analyzed, yet it does provide several implications for practice and future research. © The Author(s) 2010.


Zhang R.,Peking University | Zhang R.,Colorado State University-Pueblo | Ma M.,Peking University | Li D.,Peking University | Jiao B.,Peking University
IEEE International Conference on Communications | Year: 2015

In this paper, we focus on the downlink (DL) and uplink (UL) power control issue in a wireless full-duplex system consisting of a full-duplex base station with single antenna and mobile stations working in time-division duplex mode. First, we investigate the signal-to-interference ratios (SIRs) of DL and UL and obtain a formula reflecting their relationship. Then, by employing the Lagrange multiplier method, we derive an optimal joint power control solution to maximize the sum rate of DL and UL channels. Consequently, we propose an efficient switching scheme between the full-duplex mode and the opportunistic half-duplex mode that can be considered as a compensation mode in sum rate maximization. The proposed switching scheme is verified by numerical simulations. © 2015 IEEE.


Basar G.,Old Dominion University | Bedoya-Valencia L.,Colorado State University-Pueblo
IIE Annual Conference and Expo 2014 | Year: 2014

Colorado is generating its electricity mostly from coal, the most inexpensive electricity generation resource, and natural gas since the state has rich and vast reserves in a regulated electricity market. However, these resources are affecting environmental sustainability in a negative way. Due to the rich renewable energy profile of the state along with the recent state legislation which forces investor owned electricity utilities to produce at least 30% out of renewables by 2020, investors face the problem of how to make investments and how these investments affect the CO2 emissions. In this study, an electricity market model for the state of Colorado is developed in order to analyze the investment decision dynamics and effects on long-term CO2 emissions in the state.


PubMed | Colorado State University-Pueblo and Washington State University
Type: | Journal: SpringerPlus | Year: 2016

Fountain Creek in Colorado USA is a major tributary that confluences with the Arkansas River at Pueblo, Colorado, the result being the tributarys influence on Arkansas River water quality affecting down-stream users. In a previous study, we found that bryophytes (aquatic plants) accumulated selenium in Fountain Creek watershed and this finding prompted us to investigate the extent of the metalloid in the whole-body tissues of fish. One hundred 11 fish (six species) were collected and analyzed for Se by inductively-coupled plasma emission mass spectrometry. Analysis of all analytical data also showed mercury in all of the fish whole bodies and selected tissues. There was a general increase in selenium but a decrease in mercury in fish with downstream travel-distance. The highest whole-body selenium was in Pueblo, Colorado (3393g/kg, dry weight; 906g/kg, wet weight); the highest mercury in fish was in the Monument Creek tributary north of Colorado Springs, Colorado (71g/kg, dry weight; 19g/kg, wet weight). In four tissues of 11 female fish captured, selenium was highest in the livers at eight sites but highest in the ovaries at three sites. Mercury was highest in the epaxial muscle at all sites. Selenium availability could be due to the watershed lithology and land uses; however, mercury could be carried by atmospheric deposition from coal-fired power plants and historic mining activities. Selenium in fish tissues and water samples were compared to U.S. national water quality criteria.


PubMed | Colorado State University-Pueblo, College of William and Mary and Peking University
Type: Journal Article | Journal: Environmental toxicology and chemistry | Year: 2015

Bird eggs are used widely as noninvasive bioindicators for environmental mercury availability. Previous studies, however, have found varying relationships between laying sequence and egg mercury concentrations. Some studies have reported that the mercury concentration was higher in first-laid eggs or declined across the laying sequence, whereas in other studies mercury concentration was not related to egg order. Approximately 300 eggs (61 clutches) were collected from captive zebra finches dosed throughout their reproductive lives with methylmercury (0.3 g/g, 0.6g/g, 1.2g/g, or 2.4g/g wet wt in diet); the total mercury concentration (mean standard deviation [SD] dry wt basis) of their eggs was 7.031.38g/g, 14.152.52g/g, 26.855.85g/g, and 49.7610.37g/g, respectively (equivalent to fresh wt egg mercury concentrations of 1.24g/g, 2.50g/g, 4.74g/g, and 8.79g/g). The authors observed a significant decrease in the mercury concentration of successive eggs when compared with the first egg and notable variation between clutches within treatments. The mercury level of individual females within and among treatments did not alter this relationship. Based on the results, sampling of a single egg in each clutch from any position in the laying sequence is sufficient for purposes of population risk assessment, but it is not recommended as a proxy for individual female exposure or as an estimate of average mercury level within the clutch.


PubMed | Colorado State University-Pueblo
Type: Journal Article | Journal: Radiation research | Year: 2015

Human exposure to ionizing radiation is highly associated with adverse health effects, including reduced hematopoietic cell function and increased risk of carcinogenesis. The hematopoietic deficits manifest across blood cell types and persist for years after radiation exposure, suggesting a long-lived and multi-potent cellular reservoir for radiation-induced effects. As such, research has focused on identifying both the immediate and latent hematopoietic stem cell responses to radiation exposure. Radiation-associated effects on hematopoietic function and malignancy development have generally been attributed to the direct induction of mutations resulting from radiation-induced DNA damage. Other studies have illuminated the role of cellular programs that both limit and enhance radiation-induced tissue phenotypes and carcinogenesis. In this review, distinct but collaborative cellular responses to genotoxic insults are highlighted, with an emphasis on how these programmed responses impact hematopoietic cellular fitness and competition. These radiation-induced cellular programs include apoptosis, senescence and impaired self-renewal within the hematopoietic stem cell (HSC) pool. In the context of sporadic DNA damage to a cell, these cellular responses act in concert to restore tissue function and prevent selection for adaptive oncogenic mutations. But in the contexts of whole-tissue exposure or whole-body exposure to genotoxins, such as radiotherapy or chemotherapy, we propose that these programs can contribute to long-lasting tissue impairment and increased carcinogenesis.


PubMed | National Polytechnic Institute of Mexico, University of Stockholm, Colorado State University-Pueblo, Genoscope and 2 more.
Type: Journal Article | Journal: PloS one | Year: 2015

Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be divided into three clusters, and this division also corresponds to host specificity groups. The strains of cluster II which form symbioses with actinorhizal Rosales and Cucurbitales, thus displaying a broad host range, show suprisingly low genetic diversity and to date can not be cultured. The genome of the first representative of this cluster, Candidatus Frankia datiscae Dg1 (Dg1), a microsymbiont of Datisca glomerata, was recently sequenced. A phylogenetic analysis of 50 different housekeeping genes of Dg1 and three published Frankia genomes showed that cluster II is basal among the symbiotic Frankia clusters. Detailed analysis showed that nodules of D. glomerata, independent of the origin of the inoculum, contain several closely related cluster II Frankia operational taxonomic units. Actinorhizal plants and legumes both belong to the nitrogen-fixing plant clade, and bacterial signaling in both groups involves the common symbiotic pathway also used by arbuscular mycorrhizal fungi. However, so far, no molecules resembling rhizobial Nod factors could be isolated from Frankia cultures. Alone among Frankia genomes available to date, the genome of Dg1 contains the canonical nod genes nodA, nodB and nodC known from rhizobia, and these genes are arranged in two operons which are expressed in D. glomerata nodules. Furthermore, Frankia Dg1 nodC was able to partially complement a Rhizobium leguminosarum A34 nodC::Tn5 mutant. Phylogenetic analysis showed that Dg1 Nod proteins are positioned at the root of both - and -rhizobial NodABC proteins. NodA-like acyl transferases were found across the phylum Actinobacteria, but among Proteobacteria only in nodulators. Taken together, our evidence indicates an Actinobacterial origin of rhizobial Nod factors.


PubMed | Colorado State University-Pueblo and Washington State University
Type: Journal Article | Journal: Archives of environmental contamination and toxicology | Year: 2016

Total mercury (THg) and selenium (Se) were analyzed by Inductively Coupled Plasma Mass Spectrometry in 11 internal and external tissues and stomach contents from 23 brown trout, Salmo trutta, of a 22.9-km reach of a high-gradient stream (upper Fountain Creek) in Colorado, USA, impacted by coal-fired power plants, shale deposits, and urbanization. Trout and water were sampled from four sites ranging from 2335 to 1818m elevation. Lengths, weights, and ages of fish between pairs of the four sites were not significantly different. The dry weight (dw) to wet weight (ww) conversion factor for each tissue was calculated with egg-ovary highest at 0.379 and epaxial muscle fourth highest at 0.223. THg and Se in stomach contents indicated diet and not ambient water was the major source of Hg and Se bioaccumulated. Mean THg ww in kidney was 40.33g/kg, and epaxial muscle second highest at 36.76g/kg. None of the tissues exceeded the human critical threshold for Hg. However, all 23 trout had at least one tissue type that exceeded 0.02mg/kg THg ww for birds, and four trout tissues exceeded 0.1mg/kg THg ww for mammals, indicating that piscivorous mammals and birds should be monitored. Se concentrations in tissues varied depending on ww or dw listing. Mean Se dw in liver was higher than ovary at the uppermost site and the two lower sites. Liver tissue, in addition to egg-ovary, should be utilized as an indicator tissue for Se toxicity.


PubMed | Colorado State University-Pueblo, Bielefeld University, University of Stockholm, Justus Liebig University and University of California at Davis
Type: Journal Article | Journal: BMC genomics | Year: 2016

The ability to establish root nodule symbioses is restricted to four different plant orders. Soil actinobacteria of the genus Frankia can establish a symbiotic relationship with a diverse group of plants within eight different families from three different orders, the Cucurbitales, Fagales and Rosales. Phylogenetically, Frankia strains can be divided into four clusters, three of which (I, II, III) contain symbiotic strains. Members of Cluster II nodulate the broadest range of host plants with species from four families from two different orders, growing on six continents. Two Cluster II genomes were sequenced thus far, both from Asia.In this paper we present the first Frankia cluster II genome from North America (California), Dg2, which represents a metagenome of two major and one minor strains. A phylogenetic analysis of the core genomes of 16 Frankia strains shows that Cluster II the ancestral group in the genus, also ancestral to the non-symbiotic Cluster IV. Dg2 contains the canonical nod genes nodABC for the production of lipochitooligosaccharide Nod factors, but also two copies of the sulfotransferase gene nodH. In rhizobial systems, sulfation of Nod factors affects their host specificity and their stability.A comparison with the nod gene region of the previously sequenced Dg1 genome from a Cluster II strain from Pakistan shows that the common ancestor of both strains should have contained nodABC and nodH. Phylogenetically, Dg2 NodH proteins are sister to rhizobial NodH proteins. A glnA-based phylogenetic analysis of all Cluster II strains sampled thus far supports the hypothesis that Cluster II Frankia strains came to North America with Datisca glomerata following the Madrean-Tethyan pattern.


News Article | February 23, 2017
Site: www.prweb.com

The Community for Accredited Online Schools, a leading resource provider for higher education information, has ranked the best colleges with online programs in the state of Colorado. Among the schools that were ranked, 16 four-year colleges made the list, with University of Denver, Colorado State University Fort Collins, University of Colorado Boulder, University of Northern Colorado and University of Colorado Denver coming in as the top five schools. The state’s top 13 two-year schools were also ranked, with Trinidad State Junior College, Pueblo Community College, Aims Community College, Otero Junior College and Colorado Northwestern Community College taking the top five spots. “Colorado’s schools are becoming increasingly attuned to the needs of nontraditional students,” said Doug Jones, CEO and founder of AccreditedSchoolsOnline.org. “The accredited schools on our list accommodate all kinds of schedules with their online programs so that busy students can finish their degrees and receive a top-quality learning experience.” Schools on the “Best” list must meet specific base requirements to be included: each must be institutionally accredited, public or private not-for-profit. Each college was also scored based on more than a dozen additional data points, including student to teacher ratios, graduation rates and financial aid availability. For more details on where each school falls in the rankings and the data and methodology used to determine the lists, visit: Colorado’s Best Online Four-Year Schools for 2017 include the following: Adams State University Colorado Christian University Colorado Mesa University Colorado State University-Fort Collins Colorado State University-Global Campus Colorado State University-Pueblo Johnson & Wales University-Denver Metropolitan State University of Denver Nazarene Bible College Regis University University of Colorado Boulder University of Colorado Colorado Springs University of Colorado Denver University of Denver University of Northern Colorado Western State Colorado University Colorado’s Best Online Two-Year Schools for 2017 include the following: Aims Community College Arapahoe Community College Colorado Northwestern Community College Community College of Aurora Community College of Denver Front Range Community College Lamar Community College Morgan Community College Northeastern Junior College Otero Junior College Pikes Peak Community College Pueblo Community College Trinidad State Junior College About Us: AccreditedSchoolsOnline.org was founded in 2011 to provide students and parents with quality data and information about pursuing an affordable, quality education that has been certified by an accrediting agency. Our community resource materials and tools span topics such as college accreditation, financial aid, opportunities available to veterans, people with disabilities, as well as online learning resources. We feature higher education institutions that have developed online learning programs that include highly trained faculty, new technology and resources, and online support services to help students achieve educational success.


Jelenkovic A.,University of Helsinki | Jelenkovic A.,University of the Basque Country | Yokoyama Y.,Osaka City University | Sund R.,University of Helsinki | And 148 more authors.
Twin Research and Human Genetics | Year: 2015

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes. © The Author(s) 2015.


Long S.,Missouri University of Science and Technology | Carlo H.J.,University of Puerto Rico at Mayaguez | Grasman S.E.,Missouri University of Science and Technology | Gosavi A.,Missouri University of Science and Technology | And 2 more authors.
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2011

This paper details the use of retrospective assessment by a multi-institutional partnership to measure the level of student and faculty engagement in the course development process. This partnership includes two universities in the U.S., one in Puerto Rico, and one in Spain and is in the final year of an NSF funded project to integrate sustainability into supply chain management and facility logistics curriculum across institutional boundaries and international time zones. Lessons learned from the assessment are used to identify progress toward learning and pedagogical development goals as well as suggest measures for overcoming engagement barriers. © 2011 American Society for Engineering Education.


Long Y.,Colorado State University-Pueblo | Nah F.F.-H.,Missouri University of Science and Technology | Eschenbrenner B.,University of Nebraska at Kearney | Schoonover T.,University of Nebraska at Omaha
Industrial Management and Data Systems | Year: 2013

Purpose - The purpose of this paper is to propose a computer-supported collaborative learning (CSCL) research framework. Design/methodology/approach - The framework was developed from a review and synthesis of the literature. More specifically, gaps in the literature were identified and a general framework for future CSCL research was proposed. Findings - This paper proposes a research framework that identifies a fit profile between learning objectives, learning tasks, and technology in CSCL. The fit profile, in turn, is expected to influence users' learning processes and outcomes. Research limitations/ implications - This framework can serve as a foundation for future research in CSCL. More specifically, research should give consideration to the collaborative learning objective and task, which will vary in degrees of complexity and cognitive demands. Also, researchers will want to evaluate the level of sophistication of the CSCL technology, as well as its appropriateness for a given objective and task, which ultimately influences the learning process and outcomes. Practical implications - Considerations and guidelines for development of CSCL applications are provided. Originality/value - CSCL is an important research area that has attracted the attention of researchers from various disciplines (e.g. information systems, educational psychology). However, the findings are varied and sometimes conflict with each other. By emphasizing a fit profile between learning objectives, learning tasks, and technology, this paper proposes a theory-based research framework to address the inconsistencies observed in the literature. © Emerald Group Publishing Limited.


Lindqvist H.,Colorado State University-Pueblo | Lindqvist H.,Finnish Meteorological Institute | O'Dell C.W.,Colorado State University-Pueblo | Basu S.,National Oceanic and Atmospheric Administration | And 17 more authors.
Atmospheric Chemistry and Physics | Year: 2015

The seasonal cycle accounts for a dominant mode of total column CO2 (XCO2) annual variability and is connected to CO2 uptake and release; it thus represents an important quantity to test the accuracy of the measurements from space. We quantitatively evaluate the XCO2 seasonal cycle of the Greenhouse Gases Observing Satellite (GOSAT) observations from the Atmospheric CO2 Observations from Space (ACOS) retrieval system and compare average regional seasonal cycle features to those directly measured by the Total Carbon Column Observing Network (TCCON). We analyse the mean seasonal cycle amplitude, dates of maximum and minimum XCO2, as well as the regional growth rates in XCO2 through the fitted trend over several years. We find that GOSAT/ACOS captures the seasonal cycle amplitude within 1.0 ppm accuracy compared to TCCON, except in Europe, where the difference exceeds 1.0 ppm at two sites, and the amplitude captured by GOSAT/ACOS is generally shallower compared to TCCON. This bias over Europe is not as large for the other GOSAT retrieval algorithms (NIES v02.21, RemoTeC v2.35, UoL v5.1, and NIES PPDF-S v.02.11), although they have significant biases at other sites. We find that the ACOS bias correction partially explains the shallow amplitude over Europe. The impact of the co-location method and aerosol changes in the ACOS algorithm were also tested and found to be few tenths of a ppm and mostly non-systematic. We find generally good agreement in the date of minimum XCO2 between ACOS and TCCON, but ACOS generally infers a date of maximum XCO2 2-3 weeks later than TCCON. We further analyse the latitudinal dependence of the seasonal cycle amplitude throughout the Northern Hemisphere and compare the dependence to that predicted by current optimized models that assimilate in situ measurements of CO2. In the zonal averages, models are consistent with the GOSAT amplitude to within 1.4 ppm, depending on the model and latitude. We also show that the seasonal cycle of XCO2 depends on longitude especially at the mid-latitudes: the amplitude of GOSAT XCO2 doubles from western USA to East Asia at 45-50° N, which is only partially shown by the models. In general, we find that model-to-model differences can be larger than GOSAT-to-model differences. These results suggest that GOSAT/ACOS retrievals of the XCO2 seasonal cycle may be sufficiently accurate to evaluate land surface models in regions with significant discrepancies between the models. © Author(s) 2015.


Long S.,Missouri University of Science and Technology | Gosavi A.,Missouri University of Science and Technology | Grasman S.,Missouri University of Science and Technology | Carlo H.,University of Puerto Rico at Mayaguez | And 2 more authors.
61st Annual IIE Conference and Expo Proceedings | Year: 2011

Engineering managers need in-depth knowledge and commitment to concepts of sustainability to create infrastructures and processes capable of meeting the needs of 21st century business. Many efforts are underway to introduce necessary skill sets into engineering management and industrial engineering curriculum, but how deeply are these concepts being internalized by the students and faculty involved? This paper details the use of student and faculty assessment by a multi-institutional partnership in the implementation of sustainability-focused engineering management curriculum. This partnership includes two universities in the U.S., one in Puerto Rico, and one in Spain and is in the final year of an NSF funded project to integrate global sustainability into supply chain management and facility logistics curriculum. Lessons learned from the assessment are used to identify progress toward learning and pedagogical development goals, as well as suggest measures for overcoming engagement barriers.


News Article | October 29, 2016
Site: www.prweb.com

AffordableCollegesOnline.org, a leading online higher education information and resource provider, is highlighting 25 schools as the Best Online Colleges in Colorado for 2016-2017. Comparing more than a dozen unique cost and quality measures, the following two-year and four-year schools received top marks respectively: Lamar Community College, Colorado Northwestern Community College, Trinidad State Junior College, Northeastern Junior College and Morgan Community College; Colorado Christian University, University of Northern Colorado, University of Colorado – Colorado Springs, Adams State University and Metropolitan State University of Denver. "In 2014 alone, non-residents made up nearly half of all four-year college applicants in Colorado. That shows a growing opportunity for distance and online learning programs in the state,” said Dan Schuessler, CEO and Founder of AffordableCollegesOnline.org. "We’re highlighting colleges who are going above and beyond to create quality, affordable online programs to accommodate the growing number of students looking to Colorado for higher education resources.” Schools are required to meet specific baseline requirements to make the AffordableCollegesOnline.org lists. An institution must hold regional accreditation and be a public or private not-for-profit college or university to qualify. Tuition rates must also fall under specific minimums: two-year schools must offer an in-state tuition rate below $5,000 per year and four-year schools must offer an in-state tuition rate below $25,000 per year. All schools on the Best Online Colleges in Colorado ranking are listed below. For more details on where each ranks and the data and methodology used to determine each school’s score visit the following page: The Best Online Colleges in Colorado (Two-Year) for 2016-2017: The Best Online Colleges in Colorado (Four-Year) for 2016-2017: Colorado Christian University University of Northern Colorado University of Colorado, Colorado Springs Adams State University Metropolitan State University of Denver University of Colorado Denver Colorado State University - Fort Collins Western State Colorado University Nazarene Bible College Colorado Mesa University Colorado State University - Global Campus Colorado State University - Pueblo AffordableCollegesOnline.org began in 2011 to provide quality data and information about pursuing an affordable higher education. Our free community resource materials and tools span topics such as financial aid and college savings, opportunities for veterans and people with disabilities, and online learning resources. We feature higher education institutions that have developed online learning environments that include highly trained faculty, new technology and resources, and online support services to help students achieve educational and career success. We have been featured by nearly 1,100 postsecondary institutions and nearly 120 government organizations.


Yang T.-H.,Colorado State University-Pueblo | Choi H.-C.P.,California State University, Fullerton
International Journal of Supply Chain Management | Year: 2013

The authors present a benchmarking study on efficiencies or performance of various global manufacturers in the steel manufacturing supply chain using the analysis of DEA models. We select appropriate variables including costs of goods sold as an input variable for purchasing performance measure and net sales as an output for distribution performance measure to be used in our DEA analysis. Our analysis results from the selected five international steel manufacturers would help supply chain managers in steel manufacturing industry to evaluate and compare other large steel manufacturers for making possible strategic alliance decisions with publically available data. The contribution of this paper is to add a benchmarking analysis of global steel manufacturers with supply chain related variables for various DEA models with insights for their use of assets and expenses in evaluating their supply chain efficiency and performance. © ExcelingTech Pub. UK.


Gosavi A.,Missouri University of Science and Technology | Fraser J.M.,Colorado State University-Pueblo
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2011

Buzzwords or buzz phrases have been used in the content of numerous industrial engineering courses for several years now. Buzzwords have a finite life, which can last from five to ten years or even more. Many buzzwords that are popular today were not in existence a decade or two ago, while buzzwords that were popular about twenty years back are not in use anymore. Some buzzwords that are currently popular are lean, supply chain management, cellular manufacturing, and quick response manufacturing. Some buzzwords that were popular in the 1980s but are less popular now include total quality management, flexible manufacturing, and group technology. While some educators wholeheartedly embrace the buzzword of the day, some refuse to use them, insisting on sticking to the basics of the science. Many adopt a middle path which means using them but only occasionally. The use of buzzwords in teaching raises numerous questions. Are buzzwords unique to our profession, i.e., industrial engineering? Does a new buzzword in industrial engineering fundamentally alter the content of what we teach or should teach in our courses? In this paper, we will first attempt to answer questions such as the ones posed above. We believe that answering such questions and studying these issues can significantly benefit our community. Coming up with these answers may also help an instructor uncertain of whether the use of buzzwords is appropriate in teaching. We will make every attempt to develop an objective understanding of the numerous issues surrounding this topic. In particular, we will characterize the roots and origins of several buzzwords that are being used or have been used in industrial engineering. Thereafter, we will study whether their use has impacted industrial engineering education. We will also examine some commonly used websites to determine how important the knowledge of buzzwords is for potential employers of industrial engineering graduates. Finally, we will attempt to determine whether buzzwords confuse students or help them gain a clear vision of industrial engineering. Based on our analysis, we will formulate our own recommendations for use of buzzwords in industrial engineering curriculum. While we have used the word "buzzword" we realize that this word has emotive overtones, and we continue to search for a replacement. © 2011 American Society for Engineering Education.


Hawker M.J.,Colorado State University | Olver C.S.,Colorado State University-Pueblo | Fisher E.R.,Colorado State University
Biointerphases | Year: 2016

Three-dimensional synthetic constructs with complex geometries have immense potential for use in a multitude of blood-contacting applications. Understanding coagulation phenomena is arguably the most critical aspect for applications involving synthetic biomaterials; however, real-time evaluation of the clot formation while interfacing with these materials is difficult to achieve in a reproducible and robust manner. Here, work representing first steps toward addressing this deficit is presented, wherein modified consumables for a clinical instrument (a Thromboelastograph®) have been fabricated. Thromboelastography (TEG) measures viscoelastic properties throughout clot formation and therefore provides clinically relevant coagulation measurements in real time (i.e., kinetics and strength of clot formation). Through our modification, TEG consumables can readily accommodate three-dimensional materials (e.g., those for regenerative tissue applications). The authors performed proof-of-concept experiments using polymer scaffolds with a range of surface properties and demonstrated that variations in surface properties resulted in differences in blood plasma coagulation dynamics. For example, the maximum rate of thrombus generation ranged from 22.2±2.2 (dyn/cm2)/s for fluorocarbon coated scaffolds to 8.7±1.0 (dyn/cm2)/s for nitrogencontaining scaffolds. Through this work, the ability to make real-time coagulation activity measurements during constant coagulation factor interface with biomedically relevant materials is demonstrated. © 2016 American Vacuum Society.


Kwon H.-B.,Colorado State University-Pueblo | Lee J.,Rowan University
Expert Systems with Applications | Year: 2015

The purpose of this paper is to explore an innovative performance model for a two-stage sequential production process by combining data envelopment analysis (DEA) and back propagation neural network (BPNN). Recent literature shows a growing interest on performance modeling of two-stage production process using DEA. But, most previous studies on the scope of two-stage modeling are still limited to the efficiency measurement and also have neglected the progressive direction of predictive value and capacity. As an optimization technique, two-stage DEA model lacks predictive capacity. Despite an adaptive prediction model being a practical necessity, this area has rarely been addressed in the previous studies. This paper demonstrates an integrative approach to constructive performance modeling of a two-stage sequential production process by exploring predictive capacity of BPNN in conjunction with DEA. The effectiveness of our jointly integrated performance model through this study is empirically supported by its practical application to the financial banking operations across large U.S. banks. © 2015 Elsevier Ltd. All rights reserved.


Apa A.D.,Colorado Parks and WildlifeCO | Wiechman L.A.,Colorado State University-Pueblo
Zoo Biology | Year: 2015

Gunnison sage-grouse (Centrocercus minimus) are distributed across southwestern Colorado and southeastern Utah, United States. Their distribution has decreased over the past century and the species has been listed as threatened by the U.S. Fish and Wildlife Service. Reduced genetic diversity, small population size, and isolation may affect Gunnison sage-grouse population persistence. Population augmentation can be used to counteract or mitigate these issues, but traditional translocation efforts have yielded mixed, and mostly unsuccessful, results. Captive-rearing is a viable, although much debated, conservation approach to bolster wild conservation-reliant species. Although there have been captive-rearing efforts with greater sage-grouse (C. urophasianus), to date, no information exists about captive-rearing methods for Gunnison sage-grouse. Therefore, we investigated techniques for egg collection, artificial incubation, hatch, and captive-rearing of chicks, juveniles, subadults, and adults for Gunnison sage-grouse. In 2009 we established a captive flock that produced viable eggs. From 2009-2011, we collected and artificially incubated 206 Gunnison sage-grouse eggs from 23 wild and 14 captive females. Our hatchability was 90%. Wild-produced eggs were heavier than captive-produced eggs and lost mass similarly during incubation. We produced 148 chicks in captivity and fed them a variety of food sources (e.g. invertebrates to commercial chow). Bacterial infections were the primary cause of chick mortality, but we successfully reduced the overall mortality rate during the course of our study. Conservationists and managers should consider the utility in developing a captive-rearing program or creating a captive population as part of a proactive conservation effort for the conservation-reliant Gunnison sage-grouse. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.


Shepherd M.,University of Colorado at Colorado Springs | Mejias R.,Colorado State University-Pueblo | Klein G.,University of Colorado at Colorado Springs
Proceedings of the Annual Hawaii International Conference on System Sciences | Year: 2014

This is the second part of a longitudinal study that examines how employee Internet abuse may be reduced by non-technical deterrence methods, specifically via IT acceptable use policies (AUP). Both studies used actual usage and audit logs (not self-reporting measures) to monitor the web activity of employees. In the earlier study, a mild AUP reminder to company employees resulted in a 12 percent decrease in non-work Internet usage. The current study utilized a more severe AUP communication and resulted in a 33 percent decrease in non-work Internet usage. For both studies, the AUP reminder resulted in an immediate decrease in non-work Internet usage. Results indicate that while non-work traffic under both treatments returned over time, the longevity effect of the severe AUP message was greater than the mild AUP message and non-work traffic did not return to its previous pre-treatment level by the end of the study. © 2014 IEEE.


Elsaleiby A.A.-S.,Colorado State University-Pueblo | Bedoya-Valencia L.,Colorado State University-Pueblo | Fors N.,Alexandria University
IIE Annual Conference and Expo 2010 Proceedings | Year: 2010

The aim of this paper is to introduce a strategic-operational Mixed Integer Linear Programming (MILP) model that analyzes the effect of the budgeted inventory holding cost and setup cost on the supply chain-facility location decisions. The objective function minimizes the total transportation cost among different distribution channels, the inventory holding cost, the setup cost at the warehouse, and the fixed cost of opening and operating each facility. The model was tested on problems of different sizes (small, medium, and large). Computational results and analysis for the different problems are presented.


Yuan D.,Colorado State University-Pueblo | DePalma J.L.,Colorado State University-Pueblo | Jaksic N.I.,Colorado State University-Pueblo | Fraser J.M.,Colorado State University-Pueblo
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2011

A learning community has been established for first-year students in the Department of Engineering at Colorado State University - Pueblo. Two engineering courses were linked by shared homework assignments, a robotics lab and periodical faculty meetings. A survey was developed and administered before and after the robotics lab to evaluate students' satisfaction and the knowledge gained. The results show an improvement in students' satisfaction of the overall experience. The effect of the learning community on students' learning and retention was also assessed. The positive effect of the established learning community was confirmed through higher passing rates and improved retention. © 2011 American Society for Engineering Education.


Melnykov V.,North Dakota State University | Melnykov I.,Colorado State University-Pueblo
Computational Statistics and Data Analysis | Year: 2012

An approach is proposed for initializing the expectationmaximization (EM) algorithm in multivariate Gaussian mixture models with an unknown number of components. As the EM algorithm is often sensitive to the choice of the initial parameter vector, efficient initialization is an important preliminary process for the future convergence of the algorithm to the best local maximum of the likelihood function. We propose a strategy initializing mean vectors by choosing points with higher concentrations of neighbors and using a truncated normal distribution for the preliminary estimation of dispersion matrices. The suggested approach is illustrated on examples and compared with several other initialization methods. © 2011 Elsevier B.V. All rights reserved.


Jaksic N.I.,Colorado State University-Pueblo
ASEE Annual Conference and Exposition, Conference Proceedings | Year: 2011

Developing an ability to innovate in an undergraduate engineering program has been addressed through the theory of inventive problem solving (TRIZ). In particular, an exercise using S-force analysis is developed for a computer-integrated manufacturing course. The exercise deals with an electro-mechanical pneumatic system - a desktop punch press suitable for use in a laboratory environment. First, a preliminary flawed design is analyzed to identify physical contradiction. An S-field analysis is performed so that a new design having the physical contradiction resolved can be proposed and implemented.


Nashed Z.,University of Central Florida | Raykov I.,Colorado State University-Pueblo
AIP Conference Proceedings | Year: 2012

This paper presents applications of Fitzparick functions to optimization problems. The main purpose of the present work is to introduce applications of the Fitzpatrick functions, involving their specific properties as the maximal monotonicity, or the proper, convex and lower semi-continuity, for solving optimization problems. © 2012 American Institute of Physics.


Nicolas-Rocca T.S.,San Jose State University | Schooley B.,University of South Carolina | Joo S.-J.,Colorado State University-Pueblo
Communications of the Association for Information Systems | Year: 2014

E-health systems are of ten designed without considering user -centered design principles. Past research on the topic of patient-centered e-health (PCEH) has lacked focus on the design and development of a PCEH artifact and the process for its development. In this study, information systems design theory (ISDT) is applied to design, develop, and evaluate an e-health system based on PCEH principles. The goal of the artifact in this study is to improve patient understanding of diagnoses, procedures, medications, and post-discharge instructions and empower patients with the information needed pre- and post-discharge to make informed healthcare decisions. The artifact justif ication, meta-requirements, meta-design, development, and evaluation are presented in multiple iterations- beginning with a simple picture book, and ending with a Web-based, mobile, multimedia system. Findings indicate that a PCEH approach can be useful for achieving multiple design goals. The artifact illustrates achievement of an important organizational quality improvement goal for the case study organization involved, a key physician goal to improve patient-physician engagement, and an important patient goal-to improve understanding about patientspecif ic diagnoses and health conditions prior to discharge from a hospital visit and initiation of home health care. © 2014 by the Association for Information Systems.


Reinig B.A.,San Diego State University | Mejias R.J.,Colorado State University-Pueblo
International Journal of e-Collaboration | Year: 2014

Participation equality is often a key process construct in research models that examine the effects of group support systems (GSS) technology and e-collaboration. GSS are generally thought to reduce the dispersion of participation among team members and thus make participation more equally distributed. However, research conclusions in the literature regarding participation equality are not always consistent with this finding. Researchers have used a variety of approaches to operationalize participation equality including unit-based measures, such as the standard deviation, and dimensionless measures such as the Gini coefficient and the coefficient of variation. Researchers have also varied in their measurement of participation units with some counting phenomena such as comments, words, or remarks. The authors report on an exploratory study that demonstrates conditions in which research conclusions regarding the participation equality construct are dependent on both the participation unit analyzed and whether a unit-based or dimensionless measure is used to compute participation equality. The authors conclude with recommendations for researchers investigating participation equality and practitioners that seek to measure and track participation equality in their collaborative work practices. Copyright © 2014, IGI Global.


Riley Dellaripa E.M.,Colorado State University-Pueblo | Maloney E.D.,Colorado State University-Pueblo
Journal of the Meteorological Society of Japan | Year: 2016

Observations spanning 2004–2012 from two Research Moored Array for African–Asian–Australian Monsoon Analysis and Prediction (RAMA) buoys along the equator in the Indian Ocean are used in conjunction with Tropical Rainfall Measuring Mission (TRMM) to assess the relative importance of surface latent heat fluxes to intraseasonal convection. This work is motivated by previous observational and modeling studies that have suggested the importance of wind-induced surface fluxes to the dynamics of the Madden–Julian Oscillation (MJO). Intraseasonal variability is isolated in two ways: 1) 20–100-day bandpass filtering and 2) using the global real time multivariate MJO index. Linear regression shows latent heat flux anomalies to be between 4% and 8% of precipitation anomalies when the two variables are compared using similar Wm−2 energy units. From a moist static energy budget viewpoint, these results confirm the potential of wind-induced latent heat fluxes to aid destabilization of MJO convection. Results derived from using both simple intraseasonal filtering and global MJO indices indicate that precipitation leads latent heat flux on the order of a few days, indicating surface fluxes may be more important for maintenance of deep MJO convection in addition to helping set the MJO’s propagation speed. Sensitivity tests using smoothed wind speed or thermodynamics (i.e., air temperature, relative humidity, and sea surface temperature) to compute latent heat flux show wind speed variability explains most of the latent heat flux variability on intraseasonal timescales. A similar conclusion is found via linearization of the latent heat flux formula. Additional analysis shows mesoscale and synoptic scale wind variability have negligible impact on intraseasonal latent heat flux anomalies. © 2015, Meteorological Society of Japan.


Buck K.A.,College of William and Mary | Varian-Ramos C.W.,Colorado State University-Pueblo | Cristol D.A.,College of William and Mary | Swaddle J.P.,College of William and Mary
PLoS ONE | Year: 2016

Mercury is a ubiquitous metal contaminant that negatively impacts reproduction of wildlife and has many other sub-lethal effects. Songbirds are sensitive bioindicators of mercury toxicity and may suffer population declines as a result of mercury pollution. Current predictions of mercury accumulation and biomagnification often overlook possible genetic variation in mercury uptake and elimination within species and the potential for evolution in affected populations. We conducted a study of dietary mercury exposure in a model songbird species, maintaining a breeding population of zebra finches (Taeniopygia guttata) on standardized diets ranging from 0.0-2.4 μg/g methylmercury. We applied a quantitative genetics approach to examine patterns of variation and heritability of mercury accumulation within dietary treatments using a method of mixed effects modeling known as the 'animal model'. Significant variation in blood mercury accumulation existed within each treatment for birds exposed at the same dietary level; moreover, this variation was highly repeatable for individuals. We observed substantial genetic variation in blood mercury accumulation for birds exposed at intermediate dietary concentrations. Taken together, this is evidence that genetic variation for factors affecting blood mercury accumulation could be acted on by selection. If similar heritability for mercury accumulation exists in wild populations, selection could result in genetic differentiation for populations in contaminated locations, with possible consequences for mercury biomagnification in food webs. © 2016 Buck et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Dallam G.M.,Colorado State University-Pueblo | Foust C.P.,Colorado State University-Pueblo
Health Promotion Practice | Year: 2013

The rapidly increasing rate of non-insulin-dependent diabetes (NIDDM) among both market economy and developing countries is a worldwide health phenomenon. The number of diabetics worldwide has been projected to increase from 135 million in 1995 to 300 million in 2025. The purpose of this study was to examine the relative effectiveness of three different approaches to the implementation of the Diabetes Prevention Program, a standardized diabetes prevention curriculum, in various worksite organizations within a single community. The methods of implementation selected included an intensive one-on-one counseling approach, a support group meeting approach, and a passive transfer of information approach. The intervention was successful in creating significant mean improvements overall in the participants who completed the 26-week program as follows: (a) reduction in overall mean body weight and mean body mass index, (b) reduction in overall average mean arterial blood pressure, (c) reduction in overall mean diabetes risk score, and (d) increase in overall mean physical activity level. Although the largest proportion of these changes occurred in the one-on-one intervention group, significant changes in some factors were found in all groups. This illustrates the utility of an on-site and incentive-driven approach to diabetes risk factor modification in the workplace. © 2012 Society for Public Health Education.


Salazar-Weber N.L.,Colorado State University-Pueblo | Smith J.P.,Colorado State University-Pueblo
International Journal of Alzheimer's Disease | Year: 2011

Copper misregulation has been implicated in the pathological processes underlying deterioration of learning and memory in Alzheimer's disease and other neurodegenerative disorders. Supporting this, inhibition of long-term potentiation (LTP) by copper (II) has been well established, but the exact mechanism is poorly characterized. It is thought that an interaction between copper and postsynaptic NMDA receptors is a major part of the mechanism; however, in this study, we found that copper (II) inhibited NMDA receptor-independent LTP in the CA3 region of hippocampal slices. In addition, in the CA3 and CA1 regions, copper modulated the paired-pulse ratio (PPR) in an LTP-dependent manner. Combined, this suggests the involvement of a presynaptic mechanism in the modulation of synaptic plasticity by copper. Inhibition of the copper-dependent changes in the PPR with cyclothiazide suggested that this may involve an interaction with the presynaptic AMPA receptors that regulate neurotransmitter release. Copyright © 2011 Nina L. Salazar-Weber and Jeffrey P. Smith.


Uhernik A.L.,Colorado State University-Pueblo | Tucker C.,Colorado State University-Pueblo | Smith J.P.,Colorado State University-Pueblo
Brain Research | Year: 2011

Monocarboxylic Acid Transporter 1 (MCT1) is expressed on the plasma membrane of cerebrovascular endothelial cells where it is the only known facilitator of lactic acid transport across the blood brain barrier. During stroke, brain injury, and certain other brain pathologies, anaerobic glycolysis produces severe lactic acidosis of brain tissue leading to brain cell damage. Therefore, a better understanding of factors that control MCT1 function may be the key to better understanding the origins and treatment of pathological lactic acidosis. In this study, we characterized the effects of intracellular pH in controlling MCT1 function and showed that microtubule disruption targeted this mechanism in rat cerebrovascular endothelial cells. Acidic intracellular pH values were shown to strongly inhibit lactic acid transport into the cytoplasmic space, while alkalinization of the cytoplasm significantly enhanced this transport function. These results support a better understanding of how cerebrovascular endothelial MCT1 may contribute to the development of lactic acidosis in brain pathologies, and suggest targeting it as a novel therapy.


Lee J.,Rowan University | Kwon H.-B.,Colorado State University-Pueblo
ICIMSA 2016 - 2016 3rd International Conference on Industrial Engineering, Management Science and Applications | Year: 2016

The purpose of this paper is to present an adaptive performance model using backpropagation neural network (BPNN) in scrutinizing impact of strategic factors on firm performance, especially within high-tech SMEs in U.S. The novel design approach introduced in this paper segments SMEs into high and low performance groups and captures different impact patterns of strategic variables (e.g. R&D). This paper explores both explanatory and predictive capacity of a neural network and extends its application to the measurement of relative efficiency and subsequent prediction of potential improvement. This paper demonstrates effectiveness of a neural network for SME analysis and its potential advancement toward performance modeling as an adaptive decision support tool. © 2016 IEEE.


Yager T.J.B.,U.S. Geological Survey | Furlong E.T.,U.S. Geological Survey | Kolpin D.W.,U.S. Geological Survey | Kinney C.A.,Colorado State University-Pueblo | And 3 more authors.
Journal of the American Water Resources Association | Year: 2014

In 2007, a 1.5-year field-scale study was initiated by the U.S. Geological Survey to evaluate the dissipation of contaminants of emerging concern (CECs) following a first agronomic biosolids application to nonirrigated farmland. CECs with the greatest decrease in concentration in the surface biosolids at 180 days post-application included indole, d-limonene, p-cresol, phenol, and skatol. CECs that were present in the largest concentration in 180-day-weathered biosolids included stanols, nonylphenols, bisphenol A, bis(2-ethylhexyl) phthalate, hexahydrohexamethyl cyclopenta-benzopyran (HHCB), and triclosan. CECs that were detected in pre-application soil were 3-beta coprostanol, skatol, acetophenone, beta-sitosterol, beta-stigmastanol, cholesterol, indole, p-cresol, and phenol, most of which are biogenic sterols or fragrances that have natural plant sources in addition to anthropogenic sources, yet their concentrations increased (in some cases, substantially) following biosolids application. Preliminary data indicate the nonylphenols (including NPEO1, NPEO2), OPEO1, benzo[a]pyrene, diethyl phthalate, d-limonene, HHCB, triclosan, and possibly 3-beta coprostanol, skatol, beta-sitosterol, cholesterol, indole, and p-cresol, migrated downward through the soil by 468 days post-application, but indicated little uptake by mature wheat plants. This study indicates that some CECs are sufficiently persistent and mobile to be vertically transported into the soil column following biosolids applications to the land surface, even in semiarid regions. © 2014 American Water Resources Association.


Shepherd M.M.,University of Colorado at Colorado Springs | Mejias R.J.,Colorado State University-Pueblo
International Journal of Human-Computer Interaction | Year: 2016

ABSTRACT: This two-stage longitudinal study examines how employee Internet abuse may be reduced by nontechnical deterrence methods, specifically via organizational acceptable use policies (AUPs). This study used actual employee usage and audit logs (not self-reporting survey measures) to monitor the web activity of employees. In stage 1, a mild AUP reminder sent to company employees resulted in a 12% decrease in employee Internet abuse. In stage 2, a more severe AUP reminder resulted in a 33% decrease in employee Internet abuse. For both stages, the AUP warning (regardless of severity level) resulted in an immediate and significant decrease in employee nonwork Internet use. Results indicate that the severe AUP treatment was more effective in reducing and maintaining lower levels of employee nonwork Internet use than the mild AUP treatment. Under the mild AUP treatment, employee nonwork Internet use levels returned to their pretreatment levels after only one week. However, under the severe AUP treatment, employee nonwork Internet use levels were lower than the mild AUP treatment and remained consistently lower than their pretreatment levels even after three weeks. These results suggest that nontechnical deterrence methods in the form of organizational IT use policies may constitute an effective approach to reducing employee Internet abuse, particularly if AUP policies are clear with regard to related sanctions and penalties for employee noncompliance. © 2016 Taylor & Francis.


Crowley J.P.,Colorado State University-Pueblo | Harvey-Knowles J.A.,University of Washington | Riggs N.R.,Colorado State University-Pueblo
School Psychology International | Year: 2016

Substantial research has identified the negative health outcomes associated with bullying for adolescent victims. Researchers have examined expressive writing as a possible method by which to decrease violence among adolescents. Results of these studies, however, suggest that expressive writing is associated with positive, negative, and neutral outcomes for adolescents. The present study had two aims related to these mixed findings. First, it sought to investigate the association between micro- and macro-level message processes that relate with self-regulation in adolescent writings about bullying and their reports of bullying behavior. Second, it examined whether executive function processes may play a role in explaining the inconsistent results for expressive writing among adolescents. Results identify several message processes that are linked with reports of bullying behavior directly as well as indirectly through the pathway of executive function. Implications for expressive writing interventions aimed at reducing bullying are discussed, particularly with respect to the importance of screening for executive function. © 2015, © The Author(s) 2015.


Melnykov V.,University of Alabama | Melnykov I.,Colorado State University-Pueblo | Michael S.,University of Alabama
Advances in Data Analysis and Classification | Year: 2015

Cluster analysis is a popular technique in statistics and computer science with the objective of grouping similar observations in relatively distinct groups generally known as clusters. Semi-supervised clustering assumes that some additional information about group memberships is available. Under the most frequently considered scenario, labels are known for some portion of data and unavailable for the rest of observations. In this paper, we discuss a general type of semi-supervised clustering defined by so called positive and negative constraints. Under positive constraints, some data points are required to belong to the same cluster. On the contrary, negative constraints specify that particular points must represent different data groups. We outline a general framework for semi-supervised clustering with constraints naturally incorporating the additional information into the EM algorithm traditionally used in mixture modeling and model-based clustering. The developed methodology is illustrated on synthetic and classification datasets. A dendrochronology application is considered and thoroughly discussed. © 2015 Springer-Verlag Berlin Heidelberg


Paudel A.M.,Colorado State University-Pueblo | Sarper H.,Colorado State University-Pueblo
Energy | Year: 2013

The paper presents economic analysis of a 1.2 MW capacity grid-connected photovoltaic (PV) power plant installed at the Colorado State University-Pueblo, in December 2008. The project was commissioned by a regional utility company as per the renewable energy portfolio standards guidelines of the state. The system is installed on the customer's property funded by a third party investor. The investor will receive tax credits and rebates in addition to monthly revenue from the energy sales. Array efficiency is used to measure the performance of the PV system and predict the amount of energy generation and resulting cash flows. Based on the project investment, costs and revenues, an economic model of the project is proposed. Economic analysis of the PV installation is performed using Microsoft Excel 2007 and validated by the RETScreen software. It is identified that the cost of the PV system, financial assistance program, and energy pricing are crucial for the economic viability of PV project in addition to a favorable climatic condition. IRR of the project is 10.7% for the given tax credits and rebates. At least 4% tax credit is required to have a breakeven of the project. Different economic scenarios were analyzed, and price of the PV generated energy at different levels of tax credits and IRR is presented. This analysis is applicable to large size customers who want to invest in or own a PV plant in the US. The economical model could be applicable to other regions to devise investment option instruments. The current cost scenario presented in the paper provides readers a notion of cost improvement witnessed by PV system in last four years. © 2013.


Blanton C.A.,Idaho State University | Gabaldon A.M.,Colorado State University-Pueblo
International Journal of Probiotics and Prebiotics | Year: 2012

Mitigating bone loss due to microgravity is critical for maintaining functionality. Dietary interventions that enhance hone mineralization or inhibit resorption offer a simple, low-risk approach to this problem. This study tested the efficacy of dietary synbiotics (prebiotics + probiotics) in protecting bone exposed to unloading followed by reambulation. The experiment followed a 2×2 factorial design with forty adult male rats randomly assigned to a weight loading condition (hindlimb-unloaded or normally loaded) and diet condition (synbiotic or control). Twenty rats were hindlimb-unloaded for 14 d followed by 14 d of reambulation. Rats maintained on the synbiotic diet were supplemented with fructooligosaccharides and lyophilized probiotic cultures (1 × 1011 CFU/g of equal parts Lactobacillus acidophilus and Lactococcus lactis lactis). After 28 days, the femur, tibia, and humerus were removed and trabecular and cortical structural parameters were measured using micro-computed tomography. Results showed a significant (P<0.05) beneficial main effect of synbiotics on femoral trabecular parameters including BV/TV, Tb.Sp and Tb.P. The interaction of diet x load condition was significant for several measures of femoral cortical bone in the unloaded synbiotic vs. unloaded control group. These results provide evidence suggesting dietary synbiotics as a moderately protective treatment against bone loss due to skeletal unloading. Copyright © 2012 by New Century Health Publishers, LLC.

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