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Sitnikov N.S.,University of Cologne | Sinzov A.V.,Lobachevsky State University of Nizhni Novgorod | Allegro D.,Aix - Marseille University | Barbier P.,Aix - Marseille University | And 5 more authors.
MedChemComm | Year: 2015

Based on the natural antimitotic agent allocolchicine as a lead structure, a series of novel indole-based allocolchicine congeners was synthesized and assessed in vitro for their cytostatic properties. Several compounds exhibited potent anti-proliferative and apoptosis-inducing activity towards lymphoma cells along with low unspecific cytotoxicity. The observed activity is supposed to result from the inhibition of microtubule assembly, as indicated by the tubulin polymerisation assay. © Royal Society of Chemistry 2015.

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