Ness Ziona, Israel
Ness Ziona, Israel
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Patent
Hebrew University of Jerusalem and Collplant | Date: 2014-12-08

Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.


Patent
Hebrew University of Jerusalem and Collplant | Date: 2016-02-01

Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.


Patent
Collplant and Hebrew University of Jerusalem | Date: 2013-04-25

Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.


Patent
Collplant and Hebrew University of Jerusalem | Date: 2014-03-13

Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.


Patent
Collplant | Date: 2016-05-18

The present invention relates to an article of manufacture comprising human procollagen and an antimicrobial agent.


The present invention relates to a method of producing type I collagen comprising isolating collagen from a plant which expresses in a vacuole thereof: (i) a collagen alpha 1 chain; (ii) a collagen alpha 2 chain; and (iii) human prolyl 4 hydroxylase (P4H). The present invention further relates to a method of producing type I collagen in a plant or an isolated plant cell comprising: (a) targeting to and accumulating in a vacuole of the plant or the isolated plant cell a collagen alpha 1 chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, a collagen alpha 2 chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, and an exogenous human prolyl 4 hydroxylase (P4H) including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, said collagen alpha 1 chain, said collagen alpha 2 chain and said human prolyl 4 hydroxylase (P4H) being expressed in said plant or isolated plant cell; and (b) harvesting said plant or plant cell and isolating the collagen.


The present invention relates to a type I collagen which comprises a C-terminus and/or N-terminus propeptide, obtainable by expressing in a plant or isolated plant cell a type I collagen alpha chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, a mammalian lysyl hydroxylase 3 (LH3), and a human prolyl 4 hydroxylase (P4H) including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, and accumulating said type I collagen alpha chain, said LH3 and said P4H in a vacuole of the plant or the isolated plant cell. The present invention further relates to a method of producing fibrillar collagen in a plant or an isolated plant cell comprising: (a) targeting to and accumulating in a vacuole of the plant or the isolated plant cell a collagen alpha I chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, a collagen alpha II chain including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, and an exogenous human prolyl 4 hydroxylase (P4H) including a signal peptide for targeting to a vacuole and being devoid of an ER retention sequence, said collagen alpha I chain, said collagen alpha II chain and said human prolyl 4 hydroxylase (P4H) being expressed in said plant or isolated plant cell; and (b) harvesting said plant or plant cell and isolating the collagen.


Patent
Collplant | Date: 2015-08-03

A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.


A composition of matter is disclosed which comprises crosslinked collagen, platelet rich plasma (PRP) and an inorganic salt. Methods of generating same and uses thereof are also disclosed.


Patent
Collplant | Date: 2014-11-05

Disclosed herein is a compositions-of-matter comprising a cross-linked polymer, the cross-linked polymer comprising a plurality of resilin polypeptide moieties, and at least one polymeric moiety covalently cross-linked to a plurality of the resilin polypeptide moieties via at least one cross-linking moiety, the cross-linking moiety being devoid of a biphenyl moiety. Further disclosed herein is a process for preparing the composition-of-matter, a composite material comprising the composition-of-matter and at least one additional polymeric substance bound to the cross-linked polymer, an article-of-manufacturing comprising the composition-of-matter and/or composite material, and a method of treating tissue damage or loss by implanting said article-of-manufacturing in a subject.

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