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Ness Ziona, Israel

A method of producing collagen in a plant and plants producing collagen are provided. The method is effected by expressing in the plant at least one type of a collagen alpha chain in a manner enabling accumulation of the collagen alpha chain in a subcellular compartment devoid of endogenous P4H activity, thereby producing the collagen in the plant.

Collplant and Hebrew University of Jerusalem | Date: 2014-03-13

Isolated polypeptides are disclosed comprising an amino acid sequence encoding a monomer of a fibrous polypeptide attached to a heterologous polysaccharide binding domain. Composites comprising same, methods of generating same and uses thereof are all disclosed.

Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: NMP-2010-1.2-2 | Award Amount: 3.62M | Year: 2011

Hernia operations are among the most common surgical procedures performed today with over 20 million cases annually worldwide. Hernia incidents are associated with pain and poor quality-of-life for the patient and lead to enormous healthcare costs, exceeding US $48 billion in the US annually. At present, hernia operations rely heavily on non-degradable polypropylene, polytetrafluoroethylene and nylon meshes. However, these polymers are often associated with foreign body reaction; implant failure; and hernia reoccurrence (over 42%). Moreover, leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative drug treatments. In addition, the process technologies are often associated with environmental risks. Herein, we propose a novel approach that employs recent advances in green nanotechnology and sustainable raw materials for scaffold fabrication that not only will eliminate toxic chemicals from the processes, but will also enhance functional repair due to superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh with well-defined nano-topography using cellulose; human recombinant collagen, derived from transgenic tobacco plants; and biodegradable polylactic/polyglycolic acid as raw materials. The green credentials of this innovative approach lie in the use of sustainable eco-friendly raw materials that will produce biodegradable waste products and therefore replacing hazardous chemicals currently in use. Thus, this proposal directly fits the call for the substitution of materials or components with green nano-technology.

Agency: Cordis | Branch: FP7 | Program: MC-IAPP | Phase: FP7-PEOPLE-2009-IAPP | Award Amount: 2.26M | Year: 2010

This industry-academia proposal addresses the development of technology which will enable understanding of regeneration of injured or degenerated tendons. Biomimetic fibrous composites will be designed and developed that will mimic the structure of native tendons. The project objectives are to fabricate an optimally stabilised and effectively functionalised three-dimensional collagen-resilin composite scaffold to match the properties of native tendons. Evaluation of the optimally stabilised and effectively functionalised biomimetic constructs will be conducted in vitro (cell studies, structural and mechanical properties) and in vivo (small and large animal studies). Using textile technologies, we aim to fabricate fibre extrusions that will allow future commercialisation of the three-dimensional biomimetic construct. In meeting the scientific and technological objectives of the IAPP Programme, an inter-sectorial academic industry multidisciplinary approach will be taken which maximises the potential offered by contemporary technologies This IAPP Programme will foster increased scientific dialogue between academics, industry and clinicians. One of the key benefits will be the transfer of key scientific and experimental knowledge between the institutions enabling the consortium to widen the scope of their work, beyond what is available within their own institution and merge the available technologies. This programme will provide training of both seconded and recruited staff, both in the host and parent institutions. This training will include experimental, communication and project management skills. Platform technologies developed during the lifetime of this project will result in future joint applications by partners in the consortium to the FP7 Health and FP7 NMP programmes.

Collplant | Date: 2015-08-03

A method of promoting wound healing, treating fibrosis and/or promoting angiogenesis is provided. The method comprises administering to a subject in need thereof a therapeutically effective amount of a procollagen, thereby promoting wound healing, treating fibrosis and/or promoting angiogenesis in the subject.

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