Yang X.,State Key Laboratory of Medicinal Chemical Biology |
Yang X.,Colleges of Life science |
Yao H.,State Key Laboratory of Medicinal Chemical Biology |
Yao H.,Colleges of Life science |
And 16 more authors.
Journal of Biological Chemistry | Year: 2015
Background: The GSH-dependent antioxidant system reduces atherosclerosis. Results: Inhibition of GSH production by BSO enhanced CD36 translational efficiency to induce CD36 protein expression and lipid accumulation that was blocked by antioxidant (enzyme). Conclusion: Alterations of cellular GSH and GSH/GSSG status regulate macrophage CD36 expression and cellular oxLDL uptake. Significance: Our study demonstrates an important anti-atherogenic function of the GSH-dependent antioxidant system.