College of the Atlantic , founded in 1969, is a private, liberal-arts college located in Bar Harbor on Mount Desert Island, Maine, United States. It awards bachelors and masters degrees solely in the field of human ecology, an interdisciplinary approach to learning. Focus areas include arts and design, environmental science, humanities, international studies, sustainable food systems, and socially responsible business. The college is small, with approximately 364 students and a full-time faculty of 35, and 15 part-time faculty. Tenets of the pedagogy include field-based or applied learning; small, seminar-style classes; student-directed projects; community involvement; and interdisciplinary learning. COA has a strong commitment to the environment and was the first college to be carbon neutral and one of the first to divest fossil fuel holdings from its endowment. The college appears on most of the top "green school" lists. The campus consists of 37 acres on Frenchman Bay, two organic farms, two off-shore island research stations, and a 100-acre protected area. The farms, Beech Hill Farm and Peggy Rockefeller Farms, are living laboratories for classes and student research. Peggy Rockefeller Farms includes livestock, crops, orchards. Beech Hill Farm provides produce. Both supply the award-winning dining hall with organic produce, eggs, and meat. The off-shore island properties include the Alice Eno Field Research Station on Great Duck Island where students conduct studies on Leach's storm petrels, guillemots, gulls, sparrows and other fields of natural history. The Edward McCormick Blair Research station on Mount Desert Rock is a center for the study of marine mammals and oceanographic issues. Wikipedia.
Khan M.A.,College of the Atlantic
Retina | Year: 2017
PURPOSE:: To compare clinical outcomes using angled versus straight trocar insertion during 27-gauge pars plana vitrectomy for epiretinal membrane. METHODS:: Pilot randomized controlled trial. Thirty eyes of 30 patients undergoing 27-gauge pars plana vitrectomy with membrane peeling for epiretinal membrane were randomized 1:1 to receive angled or straight trocar insertion. Intraocular pressure (IOP) and postoperative wound-related complications were compared. RESULTS:: Fifteen eyes were randomized to each the angled and straight incision groups. No significant difference in phakic status (P = 0.71) or preoperative IOP (15.1 ± 3.4 vs. 14.6 ± 3.0 mmHg, P = 0.67) existed between groups. On postoperative Day 1, eyes in the straight group had lower IOP compared with the angled group (11.8 ± 3.9 vs. 15.3 ± 5.2 mmHg, P = 0.04) and a relative decrease in IOP compared with preoperative values (11.8 ± 3.9 vs. 15.1 ± 3.4 mmHg, P < 0.01). No IOP difference between groups was present at Day 7 (P = 0.43) or Day 30 (P = 0.42). Postoperative complications included transient hypotony (1 eye, straight group) and serous choroidal detachment (1 eye, angled group). CONCLUSION:: Eyes with straight incisions had transiently lower IOP on postoperative Day 1, possibly suggestive of subclinical wound leak in the very early postoperative period. Overall, rates of hypotony and sclerotomy-related complications were similarly low between wound construction strategies. © 2017 by Ophthalmic Communications Society, Inc.
News Article | May 9, 2017
Dr. Clarke counsels clients in strategic patent procurement, IP due diligence, and worldwide prosecution in the area of biotechnology and the life sciences. He works with a broad range of clients – from small biotech start-ups and academic institutions, to mid-sized and large biotechnology and pharmaceutical companies – in the fields of cellular and molecular biology, oncology, immunology, microbiology, and virology, among others. Dr. Clarke earned his B.A. from the University of Texas in 2001, his Ph.D. in molecular microbiology from the University of Texas Southwestern Medical Center in 2006, and his J.D., with distinction, from Suffolk University in 2011. In 2016, he was recognized as a Rising Star by Massachusetts Super Lawyers and as a Future Leader by the Greater Boston Chamber of Commerce. Dr. Cowles possesses law firm and in-house experience in biotechnology patent preparation and prosecution, domestic and international IP portfolio management, and IP due diligence. His areas of expertise include oligonucleotide therapeutics, oncology, diagnostics, antibody, microbiology, virology, cell biology, and genomic technologies. Dr. Cowles earned his B.A., magna cum laude, in biochemistry and economics from Rice University in 1992, his Ph.D. in biomedical sciences from the University of California – San Diego in 1998, and his J.D., cum laude, from Suffolk University in 2008. He performed post-doctoral research at the Whitehead Institute/MIT as a Damon Runyon fellow, and has been recognized as a Rising Star in 2016 by Massachusetts Super Lawyers. Dr. Emmons counsels corporate and institutional clients in the preparation and prosecution of U.S. and foreign patents in the life sciences, medical device, and mechanical art areas. He assists clients with IP due diligence, IP licensing, and patentability, infringement, validity, and freedom-to-operate analyses. His areas of expertise include cell and molecular biology, genetics, and developmental biology. Dr. Emmons earned his B.A. in ecology from the College of the Atlantic in 1992, his Ph.D. in developmental biology from Washington University School of Medicine in 2000, and his J.D. from Suffolk University in 2012. He also performed post-doctoral research in the Department of Genetics at the Harvard Medical School. He has been recognized as a Rising Star (2014-2016) by Massachusetts Super Lawyers. The legal and scientific prowess of Drs. Clarke, Cowles, and Emmons further enhances Burns' existing team of high-caliber IP and business attorneys who advise life sciences companies throughout their life cycle – from technology and product licensing, patent and trademark procurement and enforcement, and strategic partnering and acquisitions to public and private financings, cross-border transactions, and export regulation compliance. The firm represents life sciences companies and entrepreneurs around the globe in diverse industries including biotechnology, clinical diagnostics, health care, medical devices, medical equipment, and pharmaceuticals, as well as academic institutions and research organizations. About Burns & Levinson LLP At Burns & Levinson, we provide high-level, client-centric and results-oriented legal services to our regional, national and international clients. We are a full-service law firm with over 125 lawyers in Boston, Providence and other regional offices. The firm has grown steadily and strategically throughout the years and has become a premier law firm. Our areas of expertise include: business/finance, business litigation/dispute resolution, divorce/family law, venture capital/emerging companies, employment, estate planning, government investigations, intellectual property, M&A/private equity, probate/trust litigation, and real estate. We partner with our clients to solve their business and personal legal issues in a collaborative, creative, and cost-effective way. For more information, visit Burns & Levinson at www.burnslev.com. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/burns--levinson-expands-intellectual-property-practice-with-addition-of-three-life-sciences-partners-300454214.html
Kaur G.,College of the Atlantic |
Bakshi M.S.,Mount Saint Vincent University
Journal of Physical Chemistry C | Year: 2010
Se-Te alloy nanocrystals (NCs) were synthesized in aqueous micellar phase at 85 °C by using Na2SeO3/Na2TeO 3 as Se/Te source in the presence of different amounts of hydrazine (i.e., 0.1-3.6 M) as reducing agent over the entire mole fraction range of Se (xSe) from xSe = 0 to 1. The shape, structure, and composition of alloy NCs were characterized by scanning electron microscopic (SEM), transmission electron microscopic (TEM), and energy dispersive X-ray spectroscopic (EDS) measurements. Despite many similar characteristic features of elemental Se and Te, a drastic change in the morphology of NCs was observed from xSe = 0 to 1. Amorphous water-soluble Se nanoparticles were obtained at xSe = 1 in the presence of excess of hydrazine, whereas long nanoribbons of several micrometers of Te were produced at xSe = 0. In the intermediate mole fractions, a smooth transition in the morphology from predominantly rhombohedral in the Se rich-region to long nanoribbons in the Te rich-region of the mixtures was observed. At relatively much lower hydrazine concentration, large plate-like morphologies were obtained at xSe = 1, while the morphologies at other mole fractions were slightly distorted with greater effect in the Se rich-region of the mixtures. A careful EDS analysis on each kind of morphology revealed a homogeneous mixing between elemental Se and Te but with a significantly nonideal behavior over the whole mole fraction range. All results were summarized in a phase diagram depicting the relationship between stochiometric amounts of Se and Te with their atomic percent in crystalline phase. NCs were always highly rich in the Te contents even in the Se rich-region of the mixtures and the overall growth was predominantly driven by metalloid (crystalline) nature of Te rather than nonmetallic (amorphous) nature of Se. © 2010 American Chemical Society.
Schiller B.,Satellite Healthcare |
Bhat P.,College of the Atlantic |
Sharma A.,Pacific Renal Research Institute
Clinical Therapeutics | Year: 2014
Background Intravenous (IV) iron is the treatment of choice for iron-deficiency anemia (IDA) in patients with dialysis-dependent chronic kidney disease (DD-CKD). However, IV iron products have been associated with serious adverse events (SAEs), including anaphylactoid reactions. Ferumoxytol is an IV iron preparation that can be injected over a short period of time. Although randomized clinical trials support ferumoxytol's efficacy and safety, additional insights may be drawn from the acquisition of long-term, repeat dosing efficacy and safety data in a real-world setting. Objective The goal of this study was to characterize the effectiveness and safety profile of ferumoxytol as administered to adult DD-CKD patients with IDA in a real-world setting. The ability of ferumoxytol to maintain hemoglobin (Hb), transferrin saturation (TSAT), and ferritin treatment targets established by the 2006 Kidney Disease Outcomes Quality Initiative guidelines was determined in 3 medium-sized US-based dialysis chains. Methods This retrospective, observational study was conducted to examine laboratory and dosing data for all patients who received any dose of ferumoxytol at 3 US-based dialysis chains over a 12-month period. Investigators and/or physicians from each of the chains also made independent determinations regarding the seriousness of any adverse event (AE). Special attention was paid to the incidence and types of AEs and SAEs that were potentially associated with ferumoxytol. Results Over the 12-month observation period, 8666 patients (mean [SD] age in chains A, B and C, 63.9 [14.8], 63.9 [14.9] and 63.6 [15.1], respectively), were treated with 33,358 doses of ferumoxytol across the 3 chains. Treatment with ferumoxytol corresponded to an increased mean monthly Hb level relative to baseline (0.13-0.69 g/dL) and led to an increase in the proportion of patients maintained within the target Hb range of 10 to 12 g/dL (61%-72%). Ferumoxytol was also associated with increases in TSAT and ferritin that stabilized throughout the observation period. Incidence of AEs was similar across the 3 chains; between 0.07% and 1.77% of all patients treated at each chain experienced an AE associated with ferumoxytol administration. SAEs were reported in 0.2% of patients. The most common AEs reported (≥6 patients) were nausea (0.37% of patients), pruritus (0.29%), vomiting (0.25%), hypotension (0.21%), and dyspnea (0.20%). Two patients (0.02%) experienced anaphylactoid reactions. The AE profile of ferumoxytol remained consistent with that reported from controlled clinical trials. Conclusions These long-term data, which include repeat dosing in a large number of DD-CKD patients with IDA in a real-world setting, confirm the effectiveness of ferumoxytol in increasing and maintaining Hb levels within the target range and with favorable assessments of long-term safety. © 2014 Elsevier HS Journals, Inc. All rights reserved.
Traversa D.,University of Teramo |
Di Cesare A.,University of Teramo |
Conboy G.,College of the Atlantic
Parasites and Vectors | Year: 2010
Cardiopulmonary nematodes of dogs and cats cause parasitic diseases of central relevance in current veterinary practice. In the recent past the distribution of canine and feline heartworms and lungworms has increased in various geographical areas, including Europe. This is true especially for the metastrongyloids Aelurostrongylus abstrusus, Angiostrongylus vasorum and Crenosoma vulpis, the filarioid Dirofilaria immitis and the trichuroid Eucoleus aerophilus (syn. Capillaria aerophila). The reasons of this emergence are little known but many drivers such as global warming, changes in vector epidemiology and movements in animal populations, may be taken into account. The purpose of this article is to review the knowledge of the most important heartworm and lungworm infections of dogs and cats in Europe. In particular recent advances in epidemiology, clinical and control are described and discussed. © 2010 Traversa et al; licensee BioMed Central Ltd.
Stryhn H.,University of Prince Edward Island |
Christensen J.,College of the Atlantic
Preventive Veterinary Medicine | Year: 2014
This paper discusses statistical modelling for data with a hierarchical structure, and distinguishes in this context between three different meanings of the term hierarchical model: to account for clustering, to investigate variability and separate predictive equations at different hierarchical levels (multi-level analysis), and in a Bayesian framework to involve multiple layers of data or prior information. Within each of these areas, the paper reviews both past developments and the present state, and offers indications of future directions. In a worked example, previously reported data on piglet lameness are reanalyzed with multi-level methodology for survival analysis, leading to new insights into the data structure and predictor effects. In our view, hierarchical models of all three types discussed have much to offer for data analysis in veterinary epidemiology and other disciplines. © 2013 Elsevier B.V.
Christensen J.,College of the Atlantic
Preventive Veterinary Medicine | Year: 2012
This manuscript was written in honour of Dr. Preben Willeberg to illustrate some tools that may be useful to " make surveillance happen" and to build bridges between science and application in animal health surveillance.The paper illustrates how four elements (science, project management, communication and documentation) may be combined with some tools into a practical framework for Foreign Animal Disease surveillance. Specifically, I will show how the four elements are essential to make surveillance happen and provide a link between science and application in animal health surveillance. The Canadian Notifiable Avian Influenza Surveillance system is used as an example.In surveillance for Foreign Animal Diseases (FAD), with veterinary authorities as the lead and with many stakeholders, . project management can support . science in building evidence (. documentation) that can be delivered (. communicated) to trade negotiators and international trade partners. To bridge the gap between science and application in FAD surveillance I propose that we need people with skills in science, project management, communication and documentation. © 2012.
Jordan P.W.,The Jackson Laboratory |
Karppinen J.,The Jackson Laboratory |
Karppinen J.,College of the Atlantic |
Handel M.A.,The Jackson Laboratory
Journal of Cell Science | Year: 2012
During meiosis, accurate coordination of the completion of homologous recombination and synaptonemal complex (SC) disassembly during the prophase to metaphase I (G2/MI) transition is essential to avoid aneuploid gametes and infertility. Previous studies have shown that kinase activity is required to promote meiotic prophase exit. The first step of the G2/MI transition is the disassembly of the central element components of the SC; however, the kinase(s) required to trigger this process remains unknown. Here we assess roles of polo-like kinases (PLKs) in mouse spermatocytes, both in vivo and during prophase exit induced ex vivo by the phosphatase inhibitor okadaic acid. All four PLKs are expressed during the first wave of spermatogenesis. Only PLK1 (not PLK2-4) localizes to the SC during the G2/MI transition. The SC central element proteins SYCP1, TEX12 and SYCE1 are phosphorylated during the G2/MI transition. However, treatment of pachytene spermatocytes with the PLK inhibitor BI 2536 prevented the okadaic-acid-induced meiotic prophase exit and inhibited phosphorylation of the central element proteins as well as their removal from the SC. Phosphorylation assays in vitro demonstrated that PLK1, but not PLK2-4, phosphorylates central element proteins SYCP1 and TEX12. These findings provide mechanistic details of the first stage of SC disassembly in mammalian spermatocytes, and reveal that PLK-mediated phosphorylation of central element proteins is required for meiotic prophase exit. © 2012.
Hicks B.J.,College of the Atlantic
Myrmecological News | Year: 2012
The Eurasian ant Myrmica rubra (LINNAEUS, 1758) invaded North America more than 100 years ago. Here, we report the first records of M. rubra from Newfoundland, as well as the first North American record of male dispersal swarms. These records, from Carbonear, Corner Brook, and St. John's, are the northernmost (48° 56' N) reliable records of M. rubra in North America. Like with other polygynous invasive ants where queen dispersal seems to be limited, we discuss a potential role of male dispersal in maintaining gene flow among colonies in light of observations of male-only swarming in Newfoundland.
Anderson M.D.,College of the Atlantic
Journal of Rural Studies | Year: 2013
The right to food is widely accepted by nations, with the notable exception of the United States (US) and four other countries. The US government deals with domestic food insecurity through an array of needs-based food assistance programs instead of rights-based approaches; and administration officials have resisted the right to food for several decades, claiming that accepting this right would bind US actions in undesirable and contradictory ways. Food insecurity persists in the US, where 48.8 million people including 16.2 million children lived in food-insecure households in 2010. Recognizing the right to food could be a meaningful first step in overcoming chronic domestic food insecurity. This paper clarifies the distinction between the responsibilities for food security that are currently respected, protected and fulfilled by the US government and those that would be necessary were the right to healthy food accepted in full. These responsibilities extend from the community to international levels, affecting Farm Bill-based domestic funding as well as foreign aid and development efforts of the US government and philanthropic organizations based in the US. Meaningful progress is being made toward realizing the right to healthy food in the US through community-based nongovernmental organizations (NGOs). Although such organizations come closer to facilitating the right to healthy food than the federal government or national anti-hunger NGOs, this right cannot be achieved in full without coordinated efforts by community-based and national NGOs, the private sector and multiple levels of government. Broad adoption of a rights-based approach and responsibilities associated with the right to healthy food by government agencies and US-based philanthropic organizations can help to remove barriers to the right to healthy food and provide focus to food system reform efforts in the US; harmonization with international efforts to promote food security; and eradication of hunger, food insecurity and malnutrition (both under-nutrition and over-nutrition) in the US and globally. © 2012 Elsevier Ltd.