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Cahoon S.,College of Logistics | Pateman H.,College of Logistics | Chen S.-L.,College of Logistics
Journal of Transport Geography | Year: 2013

For a regional port necessarily involved in global supply chains, the development of its hinterland region is critical to its long term sustainability. Such development can be fostered by a regional innovation system (RIS), although the risks of path dependency and lock-in may lead to a region decaying. A process for contributing to a RIS is the Regional Development Platform Model (RDPM), the focus of this paper. As a new approach to regional development, the RDPM is utilised and adapted to identify opportunities for potential development in a region. In this paper, the RDPM is linked to the role of a port authority and its potential to drive regional growth centred on its innovation network. Port authorities, by assuming the role of network leader, can shape the regional innovation network and create new development trajectories through their links to various levels of government and the wide range of stakeholders that utilise the port facilities. The inherent tensions in this role and the competing possibilities of path creation and path dependence to create value for a wide network of stakeholders are challenging.The paper investigates the use of the RDPM and how port authorities can influence development strategies for mutual benefit in this context. More specifically, a case study of the Burnie Port in Tasmania, Australia is conducted by utilising desktop research, interviews, an expert panel and industry roundtable to demonstrate that the RDPM has the potential as an approach beyond analysing the main sources of path dependency in a local region. By following the adaptation of the RDPM, it is argued that the trajectory of path dependency can be interrupted, for example by a port authority, enabling the potential for new paths to be created. © 2012 Elsevier Ltd.

Cheng S.-X.,College of Logistics | Tu Y.,College of Logistics | Zhang S.,College of Logistics
PLoS ONE | Year: 2013

Forkhead box M1 (FoxM1) is a member of the forkhead transcription factor family and is overexpression in malignant gliomas. However, the molecular mechanisms by which FoxM1lead to glioma carcinogenesis and progression are still not well known. In the present study, we show that Anxa1 was overexpression in gliomas and predicted the poor outcome. Furthermore, Anxa1 closely related to the FoxM1 expression and was a direct transcriptional target of FoxM1. Overexpression of FoxM1 up-regulated Anxa1 expression, whereas suppression of FoxM1 expression down-regulated Anxa1 expression in glioma cells. Finally, FoxM1 enhanced the proliferation, migration, and angiogenesis in Anxa1-dependent manner both in vitro and in vivo. Our findings provide both clinical and mechanistic evidences that FoxM1 contributes to glioma development by directly up-regulating Anxa1 expression. © 2013 Cheng et al.

Chen Y.M.,Yuan Ze University | Wang W.-S.,College of Logistics
International Journal of Systems Science | Year: 2010

The objective proposed is of environmental/economic dispatch (EED) taking into account the environmental impact to achieve simultaneously the minimisation of fuel costs and pollutant emissions, while satisfying the operational constraints of power systems. The multiarea environmental/economic dispatch (MEED) deals with the optimal power dispatch of multiple areas (or countries). In this investigation, EED/MEED is proposed to address the environmental issue during the economic dispatch. In this article, the EED/MEED problem is first formulated and then a proposed Pareto archive multiobjective particle swarm optimisation (PAMPSO) algorithm is developed to derive a set of Pareto-optimal solutions. Its aim is to dispatch the power among different areas by simultaneously minimising the operational costs and pollutant emissions. In the proposed PAMPSO, local search is used to increase its search efficiency. To ensure the system security, tie-line transfer limits between different areas are incorporated as a set of constraints in the optimisation process. Numerical studies based on a four-area test power generation system are carried out to demonstrate the validity of the proposed optimisation method as well as the results from different problem formulations. Comparative results of PAMPSO and three other competitive multiobjective evolutionary algorithms (MOEAs) are also presented. © 2010 Taylor & Francis.

Renjie W.,College of Logistics | Haiqian L.,College of Logistics
Cancer Letters | Year: 2015

MiR-132, miR-15a and miR-16 have been implicated in the pathogenesis of many types of cancer, including pituitary tumors. However, the molecular mechanism of these miRNAs in pituitary tumor growth and metastasis is still unclear. Here, we showed that miR-132 and miR-15a/16 were less expressed in pituitary tumor cell lines, as well as in invasive pituitary tumor tissues, compared to non-invasive tumor tissues. We described that overexpression of miR-132 and miR-15a/16 resulted in the suppression of pituitary tumor cell proliferation, migration and invasion, respectively, and also inhibits the expression of proteins involved in Epithelial to Mesenchymal Transition (EMT). Then, we show that these miRNAs synergistically target Sox5 in pituitary tumor. Moreover, we found that Sox5 overexpression partially rescued miR-132, miR-15a and miR-16-mediated inhibition of cell migration, invasion and cell growth. Finally, we confirmed that Sox5 was upregulated in invasive pituitary tumor tissues, compared to non-invasion tissues. In conclusion, our data indicate that miR-132 and miR-15a/16 act as tumor suppressor genes in pituitary tumor by directly targetting Sox5, and imply that these miRNAs have potential as therapeutic targets for invasive pituitary tumor. © 2014 Elsevier Ireland Ltd.

Gurning S.,College of Logistics | Cahoon S.,College of Logistics
Maritime Policy and Management | Year: 2011

This paper assesses four major mitigation strategies (inventory and sourcing mitigation, contingency rerouting, recovery planning and business continuity planning) to determine their suitability for managing potential disruptions in the wheat supply chain. In the wheat supply chain, maritime operations have an essential role due to the critical linkages that connect the global transport of this high density and complex freight task. Maritime logistical risks are wide-ranging and include the uncertainty in vessel arrivals, inventory levels of grain at the port, variety of arriving wheat consignments, and the impact of a low rail car unloading rate and performance of maritime logistic services. These significant factors could subsequently create severe disruptive events in the supply chain process of wheat trading. A Markovian-based methodology is the prime means used to evaluate the mitigation strategies in the context of wheat transport from Australia to Indonesia. As a result, the four-stage continuous time period of the Markov chain application enables the measurement and prediction of supply chain costs and time functions in relation to potential disruptive events. This may assist entities along the wheat supply chain to be better prepared both when attempting to manage maritime disruptions and re-evaluating their supply chain operation planning. © 2011 Taylor & Francis.

Chen Y.M.,Yuan Ze University | Wang W.-S.,College of Logistics
International Journal of Industrial Engineering Computations | Year: 2010

This paper proposes a particle swarm optimization (PSO) algorithm to solve various types of economic dispatch (ED) problems in power systems such as, environmental/economic dispatch (EED) and multi-area environmental/economic dispatch. The proposed model considers the environmental impact to achieve the minimization of fuel costs and pollutant emissions, simultaneously. The EED problem is further extended to dispatch the power among different areas to aid emission allowance trading. The performance of the proposed PSO is compared with conventional method and genetic algorithm. The results clearly show that the proposed algorithms give global optimum solution compared to the other methods. The results obtained also show that the proposed PSO algorithms can provide comparable dispatch solutions with reduced computation time for all types of ED problems. © 2010 Growing Science Ltd. All rights reserved.

To investigate factors with pelvic adhesions and the effect of different degrees pelvic adhesions on fallopian tube recanalization in infertile patients. Total of 527 infertile patients undergoing hysteroscopy and laparoscopic surgery in Affiliated Hospital of Chinese People's Armed Police Forces Logistics College were studied retrospectively. According to the extent of pelvic adhesions, tubal umbrella adhesions and atresia, 377 cases were classified into adhesion groups, including 73 cases in grade I, 221 cases in grade II, 75 cases in grade III and 8 cases in grade IV based on adhesion score. The 150 cases with no obvious pelvic adhesion were matched as control group. Among 8 cases with grade IV ahesion were exluded from ahesion group the relationship between pelvic adhesions and related history, abdominal lesions, tubal patency and the prognosis were studied. (1) Related factors: the frequency of pelvic adhesion and more than 7 years of infertility of 23.9% (88/369) in adhesion group were significantly higher than 12.0% (18/150) in control groups. (2) History: compared with the control group (12.7%, 19/150; 28.7%, 43/150; 11.3%, 17/150; 12.0%, 18/150; 17.3%, 26/150), patients with pelvic adhesions present more incidence abortion (23.6%, 87/369), uterine cavity operation (38.2%, 141/369), ectopic pregnancy (20.9%, 77/369), pelvic inflammatory disease (25.5%, 94/369) and abdominopelvic surgery (31.4%, 116/369). (3) Endoscopy exploration: the incidence of hydrosalpinx (24.7%, 91/369), tube distorted (15.7%, 58/369) and salpingostomy (72.9%, 269/369) in adhesion group were higher than those in control group (2.0%, 3/150; 4.0%, 6/150; 12.0%, 18/150), but relatively lower incidence of pelvic endometriosis lesions (5.7%, 21/369) and mesosalpinx cysts (16.3%, 60/369) than those in control group (16.0%, 24/150; 30.0%, 45/150). The rate of proximal tubal recanalization (59.5%, 91/153) in adhesion group was lower than 75.4% (52/69) in control group. However, the rate of distant tubal recanalization of 84.4%, (281/333) in adhesion group and; 13/15 in control group didn't show statistical difference. (4) Prognosis: the rate of ectopic pregnancy of 9.7% (29/299) in adhesion group was significantly higher than 3.1% (4/128) in control group. Among cases with grade III adhesion exhibited the highest rate of ectopic pregnancy (13.0%, 7/54; OR = 4.62, 95%CI: 1.29 - 16.50). (5) Multivariate analysis: it was found that more than two drug abortions (OR = 3.29, 95%CI: 1.34 - 8.07), pelvic and(or) abdominal surgery history (OR = 2.20, 95%CI: 1.35 - 3.57) and pelvic inflammatory disease history (OR = 1.54, 95%CI: 1.21 - 1.97) were risk factors with pelvic adhesions. More than or equal to two drug abortion history, pelvic inflammatory disease and pelvic and abdominal surgery damage were important factors for pelvic adhesions of infertility patients, which may decrease the possibility of proximal tubal recanalization and increase ectopic pregnancy risk.

STUDY DESIGN.: We performed decompression surgery or conservative treatments on 135 cervical spondylotic myelopathy (CSM) patients with concomitant hypertension and did follow-up assessments up to 1 year to exam the change of blood pressure, spinal cord function and cervical pain. OBJECTIVE.: To determine whether concomitant hypertension is relieved after decompression surgery, and whether it is related to the improvement of spinal cord function or cervical pain. SUMMARY OF BACKGROUND DATA.: In clinical practice, we often found that some patients with CSM have concomitant hypertension. Interestingly, after CSM was treated successfully by decompression surgery, some patients’ high blood pressure returned to normal range even without oral medications. METHODS.: We enrolled 135 CSM patients with hypertension, 103 of whom received decompression surgery, and remaining 32 patients accepted conservative treatments. We did follow-up assessments at 3, 6, and 12 months. The primary endpoints were changes of blood-pressure, and secondary endpoints were changes of modified Japanese Orthopedic Association (mJOA) score and cervical pain visual analogue scale (VAS). Spearman correlation coefficients were calculated between changes in systolic blood pressure (SBP) and mJOA scores, VAS scores. RESULTS.: In patients with decompression surgery, the significant decrease in both SBP and diastolic blood pressure (DBP) that was seen 3 months and sustained through subsequent visit at 12 months. Paired-Samples t Test showed that both SBP and DBP were significantly lower than baseline blood pressure at all time points after procedure (p?

Yang L.,College of Logistics
Spine | Year: 2016

STUDY DESIGN.: We collected the samples of cervical intervertebral discs from patients with vertigo to exam the distribution and types of mechanoreceptors in diseased cervical disc. OBJECTIVE.: To determine whether mechanoreceptors are distributed more abundantly in cervical discs from patients with cervical spondylosis, and whether they are related to vertigo. SUMMARY OF BACKGROUND DATA.: Previous limited studies have found that normal cervical intervertebral discs are supplied with mechanoreceptors which have been considered responsible for proprioceptive functions. Several clinical studies have indicated that the patients with cervical spondylosis manifested significantly impaired postural control and subjective balance disturbance. METHODS.: We collected 77 samples of cervical discs from 62 cervical spondylosis patients without vertigo, 61 samples from 54 patients with vertigo, and 40 control samples from 8 cadaveric donors to investigate distribution of mechanoreceptors containing neurofilament (NF200) and S-100 protein immunoreactive nerve endings. RESULTS.: The immunohistochemical investigation revealed that the most frequently encountered mechanoreceptors were the Ruffini corpuscles in all groups of cervical disc samples. They were obviously increased in the number and deeply ingrown into inner annulus fibrosus and even into nucleus pulposus in the diseased cervical discs from patients with vertigo in comparison with the discs from patients without vertigo and control discs. Only 3 Golgi endings were seen in the 3 samples from patients with vertigo. No Pacinian corpuscles were found in any samples of cervical discs. CONCLUSIONS.: The diseased cervical discs from patients with vertigo had more abundant distribution of Ruffini corpuscles than other discs. A positive association between the increased number and ingrowth of Ruffini corpuscles in the diseased cervical disc and the incidence of vertigo in the patients with cerveical spondylosis was found, which may indicate a key role of Ruffini corpuscles in the pathogenesis of vertigo of cervical origin.Level of Evidence: 4 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Li J.W.,College of Logistics
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology | Year: 2013

To study the role of oxiracetam on traumatic brain injury in rats. Thirty Wistar rats were randomly divided into 3 groups: sham operation group, model group and treatment group. Feeney method were used to establish traumatic brain injury (TBI) model in rats in model and treatment group, and rats in sham group were only broached without hydraumatic fitted. Rats in treatment group were successive administration for 21 days with oxiracetam (100 mg/kg, ig). Neurologic impairment scores were undertook after operation of 1 d, 4 d, 7 d, 14 d and 21 d, and Morris water maze test were proceeded during 15 to 19 days after operation. Average escape latency, searching time in target quadrant and number of crossing target platform in rats were recorded. Neurologic impairment scores of rats in treatment group were significantly less than those of model group after operation of 7, 14 and 21 d (P < 0.05). Average escape latency of model group were significantly higher than those of sham operation group and treatment group (P < 0.05, P < 0.01). Searching time in target quadrant and number of crossing target platform of model group were lower than those of sham operation and treatment group (P < 0.05)). Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats.

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