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Cyra L.,College Building | Gorski J.,Technical University of Gdansk
Computer Standards and Interfaces | Year: 2011

Standards Conformity Framework (SCF) presented in this paper encompasses methods and tools which provide support for application of standards and other normative documents. The approach taken focuses on development, assessment and maintenance of an electronic document which demonstrates conformity. Such a document contains an argument structure developed in accordance with the Trust-IT methodology. The paper discusses details of the SCF approach, provides the definition of SCF application processes, presents a developed software tool, which supports the method, and reports on the experience collected in numerous projects of application of the framework. © 2010 Elsevier B.V. All rights reserved.

Cyra L.,College Building | Grski J.,Technical University of Gdansk
Reliability Engineering and System Safety | Year: 2011

Argument structures are commonly used to develop and present cases for safety, security and for other properties of systems. Such structures tend to grow excessively, which causes problems with their review and assessment. Two issues are of particular interest: (1) systematic and explicit assessment of the compelling power of an argument, and (2) communication of the result of such an assessment to relevant recipients. The paper presents a solution to these problems. The method of Visual Assessment of Arguments (VAA), being this solution, is based on the DempsterShafer theory of evidence applied to the assessment of the strength of arguments, and a visual mechanism of issuing and presenting assessments, supported by the so-called opinion triangle. In the paper we explain theoretical grounding for the method and provide guidance on its application. The results of some validation experiments are also presented. © 2010 Elsevier Ltd.

Malve H.,Novo Nordisk AS | Raut S.,College Building | Marathe P.,College Building | Rege N.,College Building
Journal of Ayurveda and Integrative Medicine | Year: 2014

Background: There has been a steady rise in number of patients suffering from dementia including dementia associated with Alzheimer's disease. Effective treatment of Alzheimer's disease dementia is an unmet medical need. Objective: To evaluate effects of formulation containing combination of Phyllanthus emblica (Pe) and Tinospora cordifolia (Tc) with and without Ocimum sanctum (Os) on learning and memory performance of normal and memory impaired rats in complex maze and compare with effects of Tinospora cordifolia and Phyllanthus emblica alone. Materials and Methods: Wistar rats; either sex (100-150 g) were divided in seven groups Control, Piracetam, Rivastigmine, Tc, Pe, Formulation 1 (Tc + Pe), and Formulation 2 (Tc + Pe + Os).The study was divided in four parts: In part 1 memory enhancement was tested in normal rats. In part 2, 3, and 4 the effects of drugs were tested in Scopolamine-, Diazepam-, and Cyclosporine-induced amnesia. Hebb-Williams maze was used to test for learning and memory. Time required to trace food and number of errors in maze were noted. Results: In normal rats, all test drugs showed significant reduction in time required to trace the food and number of errors after 24 h compared with vehicle control. Formulations 1 and 2 reduced the time required to trace food and number of errors and the results were comparable with positive control groups and comparators Tc and Pe. Formulations 1 and 2 reversed amnesia produced by Scopolamine, Diazepam, and Cyclosporine when compared with vehicle control and showed comparable results with those of positive control groups and comparators Tc and Pe. Conclusion: Formulations 1 and 2 demonstrated nootropic activity and both the formulations showed comparable nootropic activity with that of Tc and Pe alone.

Bloomfield R.,City University London | Bloomfield R.,College Building | Buzna L.,University of Zilina | Popov P.,City University London | And 2 more authors.
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

An approach to Quantitative Interdependency Analysis, in the context of Large Complex Critical Infrastructures, is presented in this paper. A Discrete state-space, Continuous-time, Stochastic Process models the operation of critical infrastructure, taking interdependencies into account. Of primary interest are the implications of both model detail (that is, level of model abstraction) and model parameterisation for the study of dependencies. Both of these factors are observed to affect the distribution of cascade-sizes within and across infrastructure. © 2010 Springer-Verlag Berlin Heidelberg.

Bloomfield R.,City University London | Bloomfield R.,College Building | Chozos N.,College Building | Salako K.,City University London
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010

The UK government recently commissioned a research study to identify the state-of-the-art in Critical Infrastructure modelling and analysis, and the government/industry requirements for such tools and services. This study (Cetifs) concluded with a strategy aiming to bridge the gaps between the capabilities and requirements, which would establish interdependency analysis as a commercially viable service in the near future. This paper presents the findings of this study that was carried out by CSR, City University London, Adelard LLP, a safety/security consultancy and Cranfield University, defense academy of the UK. © 2010 Springer-Verlag Berlin Heidelberg.

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