Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles

Qingdao, China

Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles

Qingdao, China
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Wang Z.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | Wang Z.,Qingdao University | Xia J.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | Xia J.,Qingdao University | And 14 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2015

An aptamer-functionalized hydrogel has been developed, which can be regulated by the AS1411 aptamer with the sol-gel conversion. Also the hydrogel can be further utilized for the controlled encapsulation and release of the cancer drugs. Specially, the AS1411 initiates the hybridization of acrydite-modified oligonucleotides to form the hydrogels and the presence of the target protein nucleolin leads the gel to dissolve as a result of reducing the cross-linking density by competitive target-aptamer binding. Based on the rheology of hydrogels, it is possible to utilize this material for storing and releasing molecules. In this research, the cancer drug doxorubicin is encapsulated inside the gel during the formation of the hydrogel and then released in the presence of nucleolin. Further experiments are carried out to prove the specific recognition of target matter. In vitro researches confirm that the aptamer-functionalized hydrogels can be used as drug carriers in targeted therapy and other biotechnological applications. © 2015 Elsevier B.V.


Yan Z.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | Yang M.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | Wang Z.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | Zhang F.,Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles | And 5 more authors.
Sensors and Actuators, B: Chemical | Year: 2015

Rapid and sensitive detection of the common acute lymphoblastic leukemia antigen (CD10) is crucial for diagnosing and prognosing hematopoietic tumors and several carcinomas. In the present study, a label-free immunosensor for detecting CD10 by Quartz Crystal Microbalance (QCM) was developed. The detection system has a good selectivity based on the biospecific interactions between the CD10 antigen and antibody, and the sensitivity of the immunosensor was further improved for Au NPs not only carried more antibodies but also acted as mass enhancers. Experimental results confirmed that this developed method could be conveniently used for the detection of CD10 without labeling, and CD10 could be measured quantitatively in the concentration range from 1.0 × 10-8 to 1.0 × 10-11 M. © 2015 Elsevier B.V.

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