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Shen C.,Anhui Medical University | Shen C.,Collaborative Innovation Center for Complex and Severe Dermatosis | Gao J.,Anhui Medical University | Yin X.,Anhui Medical University | And 9 more authors.
Journal of Genetics and Genomics | Year: 2015

Psoriasis (Ps) and psoriatic arthritis (PsA) are genetically complex diseases with strong genetic evidence. Recently, susceptibility genes for Ps and PsA have been identified within the late cornified envelop (. LCE) gene cluster, especially the cluster 3 (. LCE3) genes. It is noteworthy that the deletion of LCE3B and LCE3C (. LCE3C_LCE3B-del) is significantly associated with these two diseases. Gene-gene interactions between LCE3 genes and other genes are associated with Ps and PsA. LCE3 genes also have pleiotropic effect on some autoimmune diseases, such as rheumatoid arthritis, atopic dermatitis and systemic lupus erythematosus. Further studies need to focus on the potential function of LCE3 genes in the pathogenesis of Ps and PsA in the future. © 2015 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China.

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